Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biology
Jason Coult, Thomas D. Rea, Jennifer Blackwood, Peter J. Kudenchuk, Chenguang Liu, Heemun Kwok
Summary: A novel algorithm was developed to predict outcomes of defibrillation success and functional survival during ongoing CPR following VF arrest. The algorithm utilized ECG features and patient characteristics to predict outcomes, with promising performance evaluated by AUC in validation data.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Critical Care Medicine
Stephanie R. Brown, Maria Frazier, Joan Roberts, Heather Wolfe, Ken Tegtmeyer, Robert Sutton, Maya Dewan, PediRES Q Collaborative Investigators
Summary: The aim of this study was to determine the outcomes of pediatric patients who received extracorporeal cardiopulmonary resuscitation (ECPR) after in-hospital cardiac arrest. The study found a high rate of survival to ICU discharge with good neurologic outcome among the patients. No demographic or clinical variables were associated with survival after ECPR.
Article
Medicine, General & Internal
Sheldon Cheskes, P. Richard Verbeek, Ian R. R. Drennan, Shelley L. L. McLeod, Linda Turner, Ruxandra Pinto, Michael Feldman, Matthew Davis, Christian Vaillancourt, Laurie J. J. Morrison, Paul Dorian, Damon C. C. Scales
Summary: This study found that among patients with shock-refractory ventricular fibrillation, survival to hospital discharge occurred more frequently in those who received double sequential external defibrillation or vector-change defibrillation compared to standard defibrillation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Loes Mandigers, Jan-Steffen Pooth, Mark A. Wefers Bettink, Corstiaan A. den Uil, Domagoj Damjanovic, Egbert G. Mik, Sam Brixius, Diederik Gommers, Georg Trummer, Dinis dos Reis Miranda
Summary: The study found that continuous measurements of skin mitochondrial partial oxygen pressure (mitoPO(2)) in pigs treated with ECPR are feasible. The delay in initial mitoPO(2 and discrepancies with mean arterial pressure suggest potential value of additional measurements to monitor tissue perfusion quality during cardiac arrest and ECPR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Critical Care Medicine
Abdelaziz Farhat, Ryan Ruiyang Ling, Christopher L. Jenks, Wynne Hsing Poon, Isabelle Xiaorui Yang, Xilong Li, Yulun Liu, Cindy Darnell-Bowens, Kollengode Ramanathan, Ravi R. Thiagarajan, Lakshmi Raman
Summary: The study revealed a rapid expansion in the use of extracorporeal cardiopulmonary resuscitation in pediatric patients, with an overall survival rate of 46% and a 30% rate of favorable neurologic outcomes.
CRITICAL CARE MEDICINE
(2021)
Article
Emergency Medicine
Makoto Aoki, Satomi Senoo, Takaaki Mori, Takuya Fukada, Yoshiaki Kawai, Taku Kazamaki, Shokei Matsumoto, Masashi Morizane
Summary: Extracorporeal cardiopulmonary resuscitation (E-CPR) is gaining interest in resuscitation, but has a high complication rate, with one of the common complications being acute aortic dissection caused by veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Critical Care Medicine
Daniel Rob, Jana Smalcova, Ondrej Smid, Ales Kral, Tomas Kovarnik, David Zemanek, Petra Kavalkova, Michal Huptych, Arnost Komarek, Ondrej Franek, Stepan Havranek, Ales Linhart, Jan Belohlavek
Summary: In patients with refractory out-of-hospital cardiac arrest who do not respond to conventional advanced cardiac life support, the use of extracorporeal cardiopulmonary resuscitation (ECPR) may improve 180-day survival.
Article
Medicine, General & Internal
M. M. Suverein, T. S. R. Delnoij, R. Lorusso, G. J. Brandon Bravo Bruinsma, L. Otterspoor, C. V. Elzo Kraemer, A. P. J. Vlaar, J. J. van der Heijden, E. Scholten, C. den Uil, T. Jansen, B. van den Bogaard, M. Kuijpers, K. Y. Lam, J. M. Montero Cabezas, A. H. G. Driessen, S. Z. H. Rittersma, B. G. Heijnen, D. Dos Reis Miranda, G. Bleeker, J. de Metz, R. S. Hermanides, J. Lopez Matta, S. Eberl, D. W. Donker, R. J. van Thiel, S. Akin, O. van Meer, J. Henriques, K. C. Bokhoven, L. Mandigers, J. J. H. Bunge, M. E. Bol, B. Winkens, B. Essers, P. W. Weerwind, J. G. Maessen, M. C. G. van de Poll
Summary: Extracorporeal cardiopulmonary resuscitation (CPR) and conventional CPR have similar effects on survival with a favorable neurologic outcome in patients with refractory out-of-hospital cardiac arrest.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Min Woo Kim, Tae Han Kim, Kyoung Jun Song, Sang Do Shin, Chu Hyun Kim, Eui Jung Lee, Kihong Kim
Summary: The study found that self-led bystander CPR had the best outcomes in terms of neurological recovery for OHCA patients, surpassing dispatcher-assisted CPR. This indicates that self-led CPR is beneficial for improving survival rates and neurological function recovery in OHCA patients.
Article
Critical Care Medicine
Jocelyn Chai, Christopher B. Fordyce, Meijiao Guan, Karin Humphries, Jacob Hutton, Jim Christenson, Brian Grunau
Summary: Longer EMS CPR-to-ROSC interval is associated with worse hospital discharge outcomes after out-of-hospital cardiac arrest (OHCA). This study investigates whether this association extends to hospital survivors and whether pre-arrest comorbidities influence the duration of resuscitation.
Article
Emergency Medicine
Kyle Stupca, Nicholas Scaturo, Eileen Shomo, Tonya King, Marshall Frank
Summary: This study compares clinical outcomes between patients with refractory ventricular fibrillation (VF) and pulseless ventricular tachycardia (pVT) cardiac arrest who received an Emergency Medical Service (EMS) bundle, and patients who received standard Advanced Cardiac Life Support (ACLS) interventions. The results showed that patients who received the EMS bundle had lower rates of successful resuscitation, fewer pulses on arrival at the hospital, and similar rates of neurologically intact survival compared to those who received standard ACLS interventions.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Critical Care Medicine
Alexander T. Limkakeng, Jinny J. Ye, Catherine Staton, Yih Yng Ng, Benjamin S. H. Leong, Nur Shahidah, Muhammad Yazid, Alexander Gordee, Maragatha Kuchibhatla, Marcus E. H. Ong
Summary: The study showed that the Advanced Life Support Termination of Resuscitation criteria maintained high specificity and predictive value in the context of Dispatch-Assisted CPR, but there were differences in survival outcomes between unassisted CPR and DA-CPR. Further research is needed to explore these differences.
Article
Engineering, Biomedical
Alexander Sacha C. Richardson, Joseph E. Tonna, Vinodh Nanjayya, Paul Nixon, Darryl C. Abrams, Lakshmi Raman, Stephen Bernard, Simon J. Finney, Brian Grunau, Scott T. Youngquist, Stephen H. McKellar, Zachary Shinar, Jason A. Bartos, Lance B. Becker, Demetris Yannopoulos, Jan Belohlavek, Lionel Lamhaut, Vincent Pellegrino
Summary: This guideline serves as a practical guide for implementing ECPR and managing patients early following ECMO support establishment. Consensus among authors has been used to provide guidance where high-quality evidence is lacking, and the guideline will be updated as more evidence becomes available in this field.
Review
Critical Care Medicine
Adam L. Gottula, Robert W. Neumar, Cindy H. Hsu
Summary: This review focuses on considerations for establishing an extracorporeal cardiopulmonary resuscitation (ECPR) system for patients with refractory out-of-hospital cardiac arrest (OHCA). Existing studies have shown that ECPR can improve neurologically favorable outcomes. Successful ECPR programs are typically part of a comprehensive care system that optimizes all phases of cardiac arrest management.
CURRENT OPINION IN CRITICAL CARE
(2022)
Article
Critical Care Medicine
Antoine Duclos, Cecile Payet, Loredana Baboi, Bernard Allaouchiche, Laurent Argaud, Frederic Aubrun, Julien Bohe, Frederic Dailler, Jean-Luc Fellahi, Jean-Jacques Lehot, Vincent Piriou, Thomas Rimmele, Delphine Terragrossa, Stephanie Polazzi, Claude Guerin
Summary: This study found that the familiarity level between nurses in the ICU has a significant impact on patient outcomes, with higher familiarity associated with lower risk of patient deaths.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Oncology
Reisya R. R. Riantiningtyas, Florence Carrouel, Amandine Bruyas, Wender L. P. Bredie, Camille Kwiecien, Agnes Giboreau, Anestis Dougkas
Summary: The present review highlights the changes in food perception among head and neck cancer patients, including taste, texture, temperature, and other oral sensations. These changes not only have physiological importance but also convey psychological and psychosocial values. Comprehensive assessment of patients' food perception can lead to personalized dietary interventions to improve their eating experience and quality of life. More studies on oral somatosensory perception with larger sample sizes and standardized assessment methods are needed to fully understand its impact on eating behavior and quality of life.
Article
Cardiac & Cardiovascular Systems
Camelia Acatrinei, Caroline Martin-Bonnet, Gilles Rioufol, Francis Bessiere
Summary: This case report describes a patient with Fontan circulation who developed IART and initial poor haemodynamic tolerance. Both IART ablation and transcatheter aortic valve replacement were performed during the same procedure, resulting in improved haemodynamics and control of the arrhythmia.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Review
Critical Care Medicine
Martin Ruste, Matthias Jacquet-Lagreze, Jean-Luc Fellahi
Summary: Individualized hemodynamic optimization often requires cardiac output monitoring, which can be achieved through noninvasive technologies. Care providers need to be aware of the advantages and limitations of these technologies to ensure appropriate use for patient care.
CURRENT OPINION IN CRITICAL CARE
(2023)
Letter
Endocrinology & Metabolism
Charles Thivolet, Etienne Larger, Bertrand Cariou, Eric Renard, Helene Hanaire, Pierre -Yves Benhamou, Bruno Guerci, Emilie Mathiotte, Karim Chikh
DIABETES & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Amine Fikani, Martin Beaufigeau, Justine Vignon, Benoit Cosset, Ahmad Hayek, Fadi Farhat
Summary: This retrospective study analyzed consecutive patients who underwent surgery for VSR and found that post-operative use of ECLS was associated with more bleeding complications and the need for reintervention. Although mortality was similar, bleeding complications remain a major limitation for the use of ECLS.
JOURNAL OF CARDIOVASCULAR SURGERY
(2023)
Article
Clinical Neurology
Stephane Legriel, Rafael Badenes, Nicolas Engrand, Rocio Mendoza-Trujillo, Pauline Soulier, Sarah Benghanem, Michael Pizzi, Carolina Maciel, Jonathan Chelly, Benjamin Zuber, Marie Labruyere, Gaetan Plantefeve, Gwenaelle Jacq, Arnaud Galbois, Yoann Launey, Laurent Argaud, Olivier Lesieur, Alexis Ferre, Marine Paul, Antoine Guillon, Pierre Bailly, Pascal Beuret, Marie-Charlotte de-Carne, Shidasp Siami, Dalila Benzekri, Gwenhael Colin, Leidy Gaviria, Jose Luis Aldana, Cedric Bruel, Annabelle Stoclin, Nicholas Sedillot, Guillaume Geri, Daniel Samano, Evie Sobczak, Emily Swafford, Kristine O'Phelan, Arnaud Meffert, Mathilde Holleville, Stein Silva, Manoel JoseAlves da Costa, Jorge Mejia, Ayham Alkhachroum
Summary: This study aims to report the prevalence and outcomes of acute encephalopathy in patients with severe COVID-19, as well as identify the determinants of 90-day outcomes. The results showed that more than half of COVID-19 patients with acute encephalopathy had poor outcomes, which were associated with factors such as age, comorbidities, impairment of consciousness, and etiology of acute encephalopathy. This highlights the importance of recognizing and managing encephalopathy in COVID-19 patients.
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Jeroen Bertels, Patrick Dupont, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: The study aims to investigate the reversibility of diffusion-weighted imaging (DWI) lesions and its association with thrombolysis, reperfusion, and functional outcomes. It found that reversibility of DWI lesions is common in patients from the WAKE-UP trial, and it is more pronounced after thrombolysis.
Article
Food Science & Technology
Carolla El Chamieh, Islam Amine Larabi, Solene M. Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Celine Lange, Benedicte Stengel, Natalia Alencar De Pinho, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf
Summary: Proton-pump inhibitors (PPIs) are commonly used in patients with chronic kidney disease (CKD), and are associated with the retention of uremic toxins (UTs). In this cross-sectional study, we found that patients using PPIs had higher levels of certain UTs compared to other patients. These findings are important for understanding factors that modulate serum UT concentration in CKD patients.
Article
Oncology
Ferdinand Blangero, Maud Robert, Thomas Andraud, Charles Dumontet, Hubert Vidal, Assia Eljaafari
Summary: Obesity increases the risk of cancer, including breast cancer. This study proposes a new mechanism in which mesenchymal stem cells from obese adipose tissue (ob-ASC) interact with immune cells, leading to inflammation and the activation of pathogenic cells double-secreting IL-17/IFN gamma. This interaction promotes breast cancer progression by enhancing cytokine secretion, angiogenic factor secretion, metalloproteinase expression, immune checkpoint overexpression, and cell migration in breast cancer cells.
Article
Cardiac & Cardiovascular Systems
Stefana Enachi, Maxime Schleef, Chahr-Eddine Hadjseyd, Simon Leboube, Charles Fauvel, Lucie Daniel, Antoine Jobbe-Duval, Laurent Sebbag, Sandrine Lemoine, Nathan Mewton
Summary: Chronic kidney disease (CKD) is common in patients with heart failure and reduced ejection fraction (HFrEF), and it is a major factor contributing to adverse outcomes. Despite limited data, studies have shown that HFrEF therapies continue to be effective in improving cardiovascular outcomes in patients with CKD. Most HF drugs cause acute renal hemodynamic changes, but these changes stabilize or even improve after the acute phase, without long-term deterioration of renal function. This paper challenges the misconceptions about the pathophysiology of HF that hinder the implementation of disease-modifying therapy in this context and proposes a strategy for titrating HF drugs in patients with moderate, severe, and end-stage CKD.
CURRENT HEART FAILURE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pauline Delage, Berenice Segrestin, Kevin Seyssel, Stephanie Chanon, Aurelie Vieille-Marchiset, Annie Durand, Angeline Nemeth, Sylviane Metairon, Aline Charpagne, Patrick Descombes, Jorg Hager, Martine Laville, Hubert Vidal, Emmanuelle Meugnier
Summary: The adaptive response to overfeeding involves significant changes in gene expression in adipose tissue. This study investigated whether supplementation with polyphenols could affect these molecular adaptations in lean men. The results showed that polyphenol supplementation modulated gene expression in adipose tissue and potentially protected against adipose tissue expansion during weight gain.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Critical Care Medicine
Antoine Gaillet, Elie Azoulay, Etienne de Montmollin, Maite Garrouste-Orgeas, Yves Cohen, Claire Dupuis, Carole Schwebel, Jean Reignier, Shidasp Siami, Laurent Argaud, Christophe Adrie, Bruno Mourvillier, Stephane Ruckly, Jean-Marie Forel, Jean-Francois Timsit
Summary: Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV-associated-non-AIDS (HANA) conditions] may now be observed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Bani-Sadr, Dylan Pavie, Laura Mechtouff, Matteo Cappucci, Marc Hermier, Roxana Ameli, Laurent Derex, Charles De Bourguignon, Tae-Hee Cho, Omer Eker, Norbert Nighoghossian, Yves Berthezene
Summary: The presence of brush sign is associated with infarct growth after successful thrombectomy, while cerebral collateral status is not.
EUROPEAN RADIOLOGY
(2023)