Article
Cardiac & Cardiovascular Systems
Mahesh V. Madhavan, Susheel K. Kodali, Vinod H. Thourani, Raj Makkar, Michael J. Mack, Samir Kapadia, John G. Webb, David J. Cohen, Howard C. Herrmann, Mathew Williams, Kevin Greason, Philippe Pibarot, Rebecca T. Hahn, Wael Jaber, Ke Xu, Maria Alu, Craig R. Smith, Martin B. Leon
Summary: This study compared the 5-year risk-adjusted outcomes of S3 TAVR and SAVR in intermediate-risk patients and found similar rates of death and disabling stroke between the two procedures. However, the incidence of paravalvular regurgitation was higher after S3 TAVR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Taishi Okuno, Caglayan Demirel, Daijiro Tomii, Gabor Erdoes, Dik Heg, Jonas Lanz, Fabien Praz, Rainer Zbinden, David Reineke, Lorenz Raber, Stefan Stortecky, Stephan Windecker, Thomas Pilgrim
Summary: This study aimed to evaluate the risk of noncardiac surgery after TAVI. The results suggest that noncardiac surgery can be performed early after successful TAVI, and device performance may impact the risk of adverse outcomes after surgery.
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Martin B. Leon, Michael J. Mack, Rebecca T. Hahn, Vinod H. Thourani, Raj Makkar, Susheel K. Kodali, Maria C. Alu, Mahesh V. Madhavan, Katherine H. Chau, Mark Russo, Samir R. Kapadia, S. Chris Malaisrie, David J. Cohen, Philipp Blanke, Jonathon A. Leipsic, Mathew R. Williams, James M. McCabe, David L. Brown, Vasilis Babaliaros, Scott Goldman, Howard C. Herrmann, Wilson Y. Szeto, Philippe Genereux, Ashish Pershad, Michael Lu, John G. Webb, Craig R. Smith, Philippe Pibarot
Summary: In low surgical risk patients with symptomatic severe aortic stenosis, the PARTNER 3 trial showed superiority of transcatheter aortic valve replacement (TAVR) over surgery for the primary endpoint at 1 year. However, at 2 years, differences in death and stroke between TAVR and surgery were no longer significant, and TAVR patients had an increased risk of valve thrombosis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel O'Hair, Steven J. Yakubov, Kendra J. Grubb, Jae K. Oh, Saki Ito, G. Michael Deeb, Nicolas M. Van Mieghem, David H. Adams, Tanvir Bajwa, Neal S. Kleiman, Stanley Chetcuti, Lars Sondergaard, Hemal Gada, Mubashir Mumtaz, John Heiser, William M. Merhi, George Petrossian, Newell Robinson, Gilbert H. L. Tang, Joshua D. Rovin, Stephen H. Little, Renuka Jain, Sarah Verdoliva, Tim Hanson, Shuzhen Li, Jeffrey J. Popma, Michael J. Reardon
Summary: This study aimed to evaluate the 5-year incidence and clinical outcomes of hemodynamic structural valve deterioration (SVD) in patients undergoing self-expanding transcatheter aortic valve implantation (TAVI) or surgery. The results showed a lower rate of SVD in the TAVI group and its association with worse clinical outcomes.
Article
Cardiac & Cardiovascular Systems
John K. Forrest, G. Michael Deeb, Steven J. Yakubov, Hemal Gada, Mubashir A. Mumtaz, Basel Ramlawi, Tanvir Bajwa, Paul S. Teirstein, Michael DeFrain, Murali Muppala, Bruce J. Rutkin, Atul Chawla, Bart Jenson, Stanley J. Chetcuti, Robert C. Stoler, Marie-France Poulin, Kamal Khabbaz, Melissa Levack, Kashish Goel, Didier Tchetche, Ka Yan Lam, Pim A. L. Tonino, Saki Ito, Jae K. Oh, Jian Huang, Jeffrey J. Popma, Neal Kleiman, Michael J. Reardon, Low Risk Trial Investigators
Summary: This study evaluated the clinical and echocardiographic outcomes of transcatheter aortic valve replacement (TAVR) compared with surgery in low-risk patients at 3 years. It found that TAVR showed durable benefits compared with surgery in terms of reducing the incidence of all-cause mortality or disabling stroke, and also significantly improved valve hemodynamics in patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Weicong Zhang, Yake Lou, Yujiang Liu, Hongwei Wang, Chun Zhang, Linxue Qian
Summary: This study examines the cost-effectiveness of TAVR compared to SAVR in China and concludes that TAVR is currently not cost-effective, but could become cost-effective if the costs are reduced to 29,766 USD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Marwan Saad, Milind Y. Desai, Amar Krishnaswamy, Venu Menon, Phillip A. Horwitz, Samir Kapadia, Mary Vaughan Sarrazin
Summary: The study compared outcomes of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in patients with rheumatic aortic stenosis (AS), as well as TAVR in nonrheumatic AS. The results showed similar mortality rates between TAVR and SAVR for rheumatic AS patients, suggesting that TAVR could be a viable alternative to traditional surgery in this patient population.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Yi-Ming Li, Tian-Yuan Xiong, Kai Xu, Zhen-Fei Fang, Lei Jiang, Jun Jin, Sheng-Hu He, Yi-Ning Yang, Jing-Jing He, Yu-Heng Jia, Yi Zhang, Yong Peng, Yuan Feng, Mao Chen
Summary: This study delineated the clinical characteristics and outcomes of Chinese TAVR patients, finding that TAVR candidates in China had lower rates of complications and mortality compared to other international registries, and patients with BAV had lower mortality rates. These results suggest that the application of TAVR in low-risk patients will be further propelled.
CHINESE MEDICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yousif Ahmad, James P. Howard, Ahran D. Arnold, Mahesh V. Madhavan, Christopher M. Cook, Maria Alu, Michael J. Mack, Michael J. Reardon, Vinod H. Thourani, Samir Kapadia, Hans Gustav Horsted Thyregod, Lars Sondergaard, Troels Hojsgaard Jorgensen, William D. Toff, Nicolas M. Van Mieghem, Raj R. Makkar, John K. Forrest, Martin B. Leon
Summary: A meta-analysis comparing TAVI with SAVR in lower-risk patients showed a lower risk of death and death or disabling stroke at 1 year with TAVI. However, there were no significant differences in main outcomes between the two procedures in higher-risk patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Adrian Attinger-Toller, Enrico Ferrari, David Tueller, Christian Templin, Olivier Muller, Fabian Nietlispach, Stefan Toggweiler, Stephane Noble, Marco Roffi, Raban Jeger, Christoph Huber, Thierry Carrel, Thomas Pilgrim, Peter Wenaweser, Mario Togni, Stephane Cook, Dik Heg, Stephan Windecker, Jean-Jacques Goy, Stefan Stortecky
Summary: This study investigated age-related outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) and found that increasing age is associated with a linear trend for mortality, stroke, and pacemaker implantation among TAVR patients. Standardized mortality ratios were higher for TAVR patients younger than 90 years of age compared with expected rates of mortality in an age-and sex-matched Swiss population.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Marisa Avvedimento, Gilbert H. L. Tang
Summary: TAVR has revolutionized the management of AS, with advancements in technology reducing procedural risks. As indications expand to lower risk patients, new challenges such as long-term durability and optimal pharmacological management have emerged.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Nazli Okumus, Sonu Abraham, Rishi Puri, W. H. Wilson Tang
Summary: This review comprehensively examines the phenotypes of AS in the context of HF progression and explores the evolving role of TAVR in specific populations.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew Chiou, Jonathan Yap, Steven Russo, Benjamin R. Stripe, Garrett B. Wong, Jeffrey A. Southard
Summary: This study describes the causes, timing, and predictors of readmissions in intermediate-to-high-risk patients with severe symptomatic aortic stenosis who underwent transcatheter aortic valve replacement (TAVR). The results show that readmissions are associated with a higher burden of comorbidities and increased 1-year mortality.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Tadeja Kolar, Nikola Lakic, Alesa Kotnik, David Stubljar, Zlatko Fras, Matjaz Bunc
Summary: This study compared the outcomes of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) in octogenarians. The results showed similar clinical outcomes in terms of clinical endpoints in low- and medium-risk groups, but differences were observed in certain indicators such as paravalvular leak, acute kidney injury, and new onset atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Joana Maria Ribeiro, Patricio Astudillo, Ole de Backer, Ricardo Budde, Rutger Jan Nuis, Jeanette Goudzwaard, Nicolas M. Van Mieghem, Joost Lumens, Peter Mortier, Francesco Mattace-Raso, Eric Boersma, Paul Cummins, Nico Bruining, Peter P. T. de Jaegere
Summary: This review discusses how artificial intelligence can improve patient selection, pre-procedural planning, procedure execution, and follow-up in the treatment of structural heart disease, aiming to establish efficient and high-quality healthcare in a growing number of patients.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jacob Eifer Moller, Ole De Backer, Philippe Nuyens, Maarten Vanhaverbeke, Niels Vejlstrup, Lars Sondergaard
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Maarten Vanhaverbeke, Philippe Nuyens, Gintautas Bieliauskas, Lars Sondergaard, Niels Vejlstrup, Ole De Backer
Summary: This study assessed the rate of difficult IAS crossing with the ICE probe during percutaneous LAA closure, with 5% of cases facing challenges. Three facilitation techniques were identified to aid in successful IAS crossing.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Environmental Sciences
Anne A. Bjerregaard, Marie W. Petersen, Sine Skovbjerg, Lise K. Gormsen, Jose G. Cedeno-Laurent, Torben Jorgensen, Allan Linneberg, Thomas Meinertz Dantoft
Summary: Multiple chemical sensitivity (MCS) is a multifactorial somatic disorder characterized by physical reactions triggered by airborne chemicals, which have a significant negative impact on social, occupational, and everyday life. This study aimed to explore the associations between MCS and anthropometry, cardiorespiratory health, and physical performance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Ahmed Elkoumy, Andreas Ruck, Won-Keun Kim, Mohamed Abdel-Wahab, Mahmoud Abdelshafy, Ole De Backer, Hesham Elzomor, Christian Hengstenberg, Sameh K. Mohamed, Nawzad Saleh, Shahram Arsang-Jang, Henrik Bjursten, Andrew Simpkin, Christopher U. Meduri, Osama Soliman
Summary: This study demonstrates that combining the 3D-LVOT area from MDCT with TTE Doppler parameters can provide a more accurate assessment of hemodynamic parameters and prosthesis-patient mismatch (PPM) diagnosis in patients treated with transcatheter aortic valve implantation (TAVI).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Linnea Malmgren, Carl Oberg, Emil den Bakker, Felicia Leion, Joanna Siodmiak, Anna Akesson, Veronica Lindstrom, Erik Herou, Alain Dardashti, Liana Xhakollari, Gabriel Grubb, Helena Strevens, Magnus Abrahamson, Johanna Helmersson-Karlqvist, Martin Magnusson, Jonas Bjork, Ulf Nyman, Johan Arnlov, Peter Ridefelt, Torbjorn Akerfeldt, Magnus Hansson, Anna Sjostrom, Johan Martensson, Yoshihisa Itoh, David Grubb, Olav Tenstad, Lars-Olov Hansson, Isleifur Olafsson, Araceli Jarquin Campos, Martin Risch, Lorenz Risch, Anders Larsson, Gunnar Nordin, Hans Pottel, Anders Christensson, Henrik Bjursten, Arend Bokenkamp, Anders Grubb
Summary: Estimation of kidney function is commonly done using endogenous GFR-markers creatinine or cystatin C. The recommendation in 2010 to use both markers in parallel led to the identification of selective glomerular hypofiltration syndromes, which are associated with increased mortality and morbidity. These syndromes, characterized by a selective reduction in the glomerular filtration of certain molecules, such as cystatin C, have proteomic changes that promote the development of atherosclerosis and may require new treatment modalities.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Karolina Berntorp, Rebecca Rylance, Troels Yndigegn, Sasha Koul, Ole Frobert, Evald H. Christiansen, David Erlinge, Matthias Gotberg
Summary: This study evaluated the long-term clinical outcome of deferral of revascularization based on instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR). The study found no significant difference in clinical outcomes after 5 years when comparing iFR versus FFR as methods for deferral of coronary revascularization in patients presenting with stable angina pectoris and acute coronary syndrome.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Karl Teurneau-Hermansson, Jacob Ede, Marten Larsson, Marion Moseby-Knappe, Henrik Bjursten, Shahab Nozohoor, Johan Sjogren, Igor Zindovic
Summary: This study investigated whether S100B can predict neurological injury following Acute Type A Aortic Dissection (ATAAD) repair. The results showed that S100B levels at 24 hours postoperatively were independent predictors for neurological injury and 30-day mortality.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Yannick Willemen, Ole De Backer
Summary: The study by Gorla et al. confirms that the incidence of clinically overt stroke is low in contemporary, real-world transcatheter aortic valve replacement (TAVR) practice. Patients at increased risk for TAVR-related stroke may be identified based on baseline risk factors. Randomized trials in selected TAVR patients at increased risk for stroke should evaluate patient-tailored preventive measures.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Rueck, Won-Keun Kim, Mohamed Abdel-Wahab, Holger Thiele, Tanja K. Rudolph, Alexander Wolf, Jan Martin Wambach, Ole De Backer, Lars Sondergaard, Christian Hengstenberg, Mika Laine, Hirokazu Miyashita, Henrik Bjursten, Matthias Goetberg, Costanza Pellegrini, Stefan Toggweiler, Joanna J. Wykrzykowska, Osama Soliman, Nawzad Saleh, Christopher U. Meduri
Summary: This study aimed to evaluate the safety and efficacy of ACURATE neo2 in transcatheter aortic valve implantation in Europe. The results showed favorable postoperative hemodynamics and clinical outcomes, as well as a low rate of postoperative pacemaker implantation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Angelo Quagliana, Nicholas J. Montarello, Maarten Vanhaverbeke, Yannick Willemen, Laurence Campens, Lars Sondergaard, Ole De Backer
Summary: This study utilized orbital atherectomy as an auxiliary technique in transcatheter aortic valve implantation. Pre-procedural computed tomography analysis played a crucial role in selecting the most appropriate calcium management technique. A standardized, step-wise procedural execution was essential to optimize outcomes.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Hematology
Edgars Grins, Marzia Leacche, Nabin Manandhar Shrestha, Henrik Bjursten, Per Ederoth, Stefan Jovinge
Summary: This study aimed to investigate whether cytokine levels before ECMO treatment could predict AKI and examine the impact of AKI on 30-day and 1-year mortality. Serum cytokine levels were analyzed in 100 VA-ECMO-treated patients and clinical data was retrieved from the ECMO registry. The results showed that pre-cannulation IL-10 levels could predict the development of AKI and AKI was associated with increased 30-day mortality.
BLOOD PURIFICATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Henrik Bjursten
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Letter
Cardiac & Cardiovascular Systems
Henrik Bjursten, Daniel Oudin Astrom, Igor Zindovic
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Pernille Steen Baekke, Troels Hojsgaard Jorgensen, Jani Thuraiaiyah, Mathis Groning, Ole De Backer, Lars Sondergaard
Summary: This study aimed to investigate the incidence, predictors, and prognostic impact of rehospitalization within one year after transcatheter aortic valve implantation (TAVI). The results showed that rehospitalization after TAVI is common, with early rehospitalization mostly related to procedure complications and late rehospitalization associated with preexisting comorbidities. Heart failure rehospitalization was found to be associated with poor long-term survival.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)