Nanozymes-recent development and biomedical applications

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED MATERIALS

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

(2021) Hamed Nosrati et al.   JOURNAL OF NANOBIOTECHNOLOGY

Catalytic Nanomaterials toward Atomic Levels for Biomedical Applications: From Metal Clusters to Single-Atom Catalysts

(2021) Yu Fan et al.   ACS Nano

High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

(2021) Xiangqin Meng et al.   ACS Nano

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

(2021) Dong-Yang Zhang et al.   BIOMATERIALS

In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

(2021) Lufeng Zhang et al.   Nature Communications

Matching the kinetics of natural enzymes with a single-atom iron nanozyme

(2021) Shufang Ji et al.   Nature Catalysis

A Titanium Nitride Nanozyme for pH‐Responsive and Irradiation‐Enhanced Cascade‐Catalytic Tumor Therapy

(2021) Jiaming Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glucose-oxidase like catalytic mechanism of noble metal nanozymes

(2021) Jinxing Chen et al.   Nature Communications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

(2020) Binbin Ding et al.   ADVANCED MATERIALS

Specific “Unlocking” Nanozyme-based Butterfly Effect for Breaking the Evolutionary Fitness of Chaotic Tumor

(2020) Wenyao Zhen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

(2020) Yanjuan Sang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

(2020) Dongdong Wang et al.   Nature Communications

Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer

(2020) Chunfang Wei et al.   BIOMATERIALS

Advances in nanomaterials for photodynamic therapy applications: Status and challenges

(2020) Jianming Chen et al.   BIOMATERIALS

Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke

(2020) Lizhen He et al.   Science Advances

Metal–Organic Framework Derived Nanozymes in Biomedicine

(2020) Dongdong Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy

(2020) Bolong Xu et al.   ADVANCED MATERIALS

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

(2020) Tengfei Liu et al.   Nature Communications

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

(2020) Yufeng Liu et al.   Science Advances

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu 2+ Nanoassemblies

(2020) Shan Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy

(2020) Yuanlin Wang et al.   BIOMATERIALS

Assessment of pulmonary toxicity of potential antioxidant drug PEGylated nanoceria after intratracheal instillation in rats

(2020) Qinqing Qian et al.   JOURNAL OF APPLIED TOXICOLOGY

Dual detoxification and inflammatory regulation by ceria nanozymes for drug-induced liver injury therapy

(2020) Fangyuan Li et al.   Nano Today

Near‐Infrared Regulated Nanozymatic/Photothermal/Photodynamic Triple‐Therapy for Combating Multidrug‐Resistant Bacterial Infections via Oxygen‐Vacancy Molybdenum Trioxide Nanodots

(2020) Yan Zhang et al.   Small

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

(2020) Chenyang Zhang et al.   Advanced Science

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

(2020) Muyue Yang et al.   Bioactive Materials

Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

(2019) Ningqiang Gong et al.   Nature Nanotechnology

Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

(2019) Kai Zhang et al.   NANO LETTERS

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

(2019) Yanyan Huang et al.   CHEMICAL REVIEWS

Porous platinum nanoparticles as a high-Z and oxygen generating nanozyme for enhanced radiotherapy in vivo

(2019) Yan Li et al.   BIOMATERIALS

Wet/Sono‐Chemical Synthesis of Enzymatic Two‐Dimensional MnO 2 Nanosheets for Synergistic Catalysis‐Enhanced Phototheranostics

(2019) Wei Tang et al.   ADVANCED MATERIALS

Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe 2 O 4 @Metal–Organic Frameworks for Enhanced Photodynamic Therapy

(2019) Sheng‐Yan Yin et al.   ADVANCED FUNCTIONAL MATERIALS

CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species

(2019) Namrata Singh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Mechanisms of Nanozymes and Their Applications in Biomedicine

(2019) Haijiao Dong et al.   BIOCONJUGATE CHEMISTRY

A Smart Photosensitizer–Cerium Oxide Nanoprobe for Highly Selective and Efficient Photodynamic Therapy

(2019) Yifan Fan et al.   INORGANIC CHEMISTRY

A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria

(2019) Zhengwei Liu et al.   BIOMATERIALS

Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy

(2019) Magdalena Jarosz-Biej et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Movable Hollow Nanoparticles as Reactive Oxygen Scavengers

(2019) Meiling Lian et al.   Chem

A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy

(2019) Feng Liu et al.   ADVANCED MATERIALS

Ceria Nanoparticles Meet Hepatic Ischemia‐Reperfusion Injury: The Perfect Imperfection

(2019) Dalong Ni et al.   ADVANCED MATERIALS

Nanozymes-Engineered Metal–Organic Frameworks for Catalytic Cascades-Enhanced Synergistic Cancer Therapy

(2019) Chuang Liu et al.   NANO LETTERS

Nanozyme antioxidants as emerging alternatives for natural antioxidants: Achievements and challenges in perspective

(2019) Milad Ghorbani et al.   Nano Today

Mn–Porphyrin-Based Metal–Organic Framework with High Longitudinal Relaxivity for Magnetic Resonance Imaging Guidance and Oxygen Self-Supplementing Photodynamic Therapy

(2019) Meie He et al.   ACS Applied Materials & Interfaces

Intrathecal Administration of Nanoclusters for Protecting Neurons against Oxidative Stress in Cerebral Ischemia/Reperfusion Injury

(2019) Shiyong Li et al.   ACS Nano

Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

(2019) Ruijuan Yan et al.   ACS Nano

Efficient Bacteria Killing by Cu2WS4 Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability

(2019) Jingyang Shan et al.   ACS Nano

Copper/Carbon Hybrid Nanozyme: Tuning Catalytic Activity by the Copper State for Antibacterial Therapy

(2019) Juqun Xi et al.   NANO LETTERS

Fenozyme Protects the Integrity of the Blood–Brain Barrier against Experimental Cerebral Malaria

(2019) Shuai Zhao et al.   NANO LETTERS

Oxygen Vacancy‐Engineered PEGylated MoO 3 −x Nanoparticles with Superior Sulfite Oxidase Mimetic Activity for Vitamin B1 Detection

(2019) Yuan Chen et al.   Small

Biomimetic Platinum Nanozyme Immobilized on 2D Metal–Organic Frameworks for Mitochondrion-Targeting and Oxygen Self-Supply Photodynamic Therapy

(2019) Zhiguo Gao et al.   ACS Applied Materials & Interfaces

Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

(2019) Lian-Hua Fu et al.   ACS Nano

Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

(2019) Chaoxiu Ren et al.   BIOMATERIALS

Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain

(2019) Yaswanth Kuthati et al.   International Journal of Nanomedicine

Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

(2019) Xi Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioinspired Nanosponge for Salvaging Ischemic Stroke via Free Radical Scavenging and Self-Adapted Oxygen Regulating

(2019) Jinjin Shi et al.   NANO LETTERS

Tumor Catalytic–Photothermal Therapy with Yolk–Shell Gold@Carbon Nanozymes

(2018) Lei Fan et al.   ACS Applied Materials & Interfaces

Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy

(2018) Yan Zhang et al.   ACS Nano

A Magnetofluorescent Carbon Dot Assembly as an Acidic H2 O2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

(2018) Qingyan Jia et al.   ADVANCED MATERIALS

Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

(2018) Xingshu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

BSA-IrO2 : Catalase-like Nanoparticles with High Photothermal Conversion Efficiency and a High X-ray Absorption Coefficient for Anti-inflammation and Antitumor Theranostics

(2018) Wenyao Zhen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photodynamic therapy – mechanisms, photosensitizers and combinations

(2018) Stanisław Kwiatkowski et al.   BIOMEDICINE & PHARMACOTHERAPY

A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

(2018) Ting-Ting Zhang et al.   Chemical Science

ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

(2018) Jia Yao et al.   Chemical Science

Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

(2018) Lingtong Meng et al.   ACS Nano

Iridium nanocrystals encapsulated liposomes as near-infrared light controllable nanozymes for enhanced cancer radiotherapy

(2018) Liangzhu Feng et al.   BIOMATERIALS

Recent Advances in Nanozyme Research

(2018) Hui Wang et al.   ADVANCED MATERIALS

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment

(2018) Kaitlin Graham et al.   International Journal of Nanomedicine

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

(2018) Changlong Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

(2018) Dalong Ni et al.   Nature Communications

Biodegradable 2D Fe-Al Hydroxide for Nanocatalytic Tumor-Dynamic Therapy with Tumor Specificity

(2018) Zhenbang Cao et al.   Advanced Science

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

MoO3−x nanodots with dual enzyme mimic activities as multifunctional modulators for amyloid assembly and neurotoxicity

(2018) Qiusen Han et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Mimicking a Natural Enzyme System: Cytochrome c Oxidase-Like Activity of Cu2O Nanoparticles by Receiving Electrons from Cytochrome c

(2017) Ming Chen et al.   INORGANIC CHEMISTRY

Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer

(2017) Jonghoon Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycine-functionalized copper(ii) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

(2017) Karsten Korschelt et al.   Nanoscale

Impact of cerium oxide nanoparticles shape on their in vitro cellular toxicity

(2017) Valérie Forest et al.   TOXICOLOGY IN VITRO

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Tumor Microenvironment-Enabled Nanotherapy

(2017) Liying Wang et al.   Advanced Healthcare Materials

A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

(2016) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inflammation and its role in age-related macular degeneration

(2016) Anu Kauppinen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of quinone cycle in Fe2+–H2O2 system in the regeneration of Fe2+

(2016) Wei Zhou et al.   ENVIRONMENTAL TECHNOLOGY

Dual-Enzyme Characteristics of Polyvinylpyrrolidone-Capped Iridium Nanoparticles and Their Cellular Protective Effect against H2O2-Induced Oxidative Damage

(2015) Hua Su et al.   ACS Applied Materials & Interfaces

Nanomedicine in the ROS-mediated pathophysiology: Applications and clinical advances

(2015) Kevin M. Nash et al.   Nanomedicine-Nanotechnology Biology and Medicine

Co3O4 Nanoparticles with Multi-Enzyme Activities and Their Application in Immunohistochemical Assay

(2014) Jinlai Dong et al.   ACS Applied Materials & Interfaces

Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity

(2012) Zhongwen Chen et al.   ACS Nano

Intrinsic peroxidase-like activity and catalase-like activity of Co3O4 nanoparticles

(2012) Jianshuai Mu et al.   CHEMICAL COMMUNICATIONS

Physicochemical Origin for Free Radical Generation of Iron Oxide Nanoparticles in Biomicroenvironment: Catalytic Activities Mediated by Surface Chemical States

(2012) Bing Wang et al.   Journal of Physical Chemistry C

Kinetics and efficiency of H2O2 activation by iron-containing minerals and aquifer materials

(2012) Anh Le-Tuan Pham et al.   WATER RESEARCH