Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-021-01102-0
Keywords
Chemodynamic therapy; Ferroptosis; Hepatocellular carcinoma; Magnetic resonance imaging; Organic/inorganic nanoplatform
Funding
- Natural Science Foundation of Zhejiang province [LY18H180003]
- National Natural Science Foundation of China [81571662]
Ask authors/readers for more resources
The study presents a rationally designed nanoplatform that induces tumor cell death through complementary ferroptosis and apoptosis, and can guide and monitor treatment under magnetic resonance imaging.
Background: Hepatocellular carcinoma is insensitive to many chemotherapeutic agents. Ferroptosis is a form of programmed cell death with a Fenton reaction mechanism. It converts endogenous hydrogen peroxide into highly toxic hydroxyl radicals, which inhibit hepatocellular carcinoma progression. Methods: The morphology, elemental composition, and tumour microenvironment responses of various organic/inorganic nanoplatforms were characterised by different analytical methods. Their in vivo and in vitro tumourtargeting efficacy and imaging capability were analysed by magnetic resonance imaging. Confocal microscopy, flow cytometry, and western blotting were used to investigate the therapeutic efficacy and mechanisms of complementary ferroptosis/apoptosis mediated by the nanoplatforms. Results: The nanoplatform consisted of a silica shell doped with iron and disulphide bonds and an etched core loaded with doxorubicin that generates hydrogen peroxide in situ and enhances ferroptosis. It relied upon transferrin for targeted drug delivery and could be activated by the tumour microenvironment. Glutathione-responsive biodegradability could operate synergistically with the therapeutic interaction between doxorubicin and iron and induce tumour cell death through complementary ferroptosis and apoptosis. The nanoplatform also has a superparamagnetic framework that could serve to guide and monitor treatment under T2-weighted magnetic resonance imaging. Conclusion: This rationally designed nanoplatform is expected to integrate cancer diagnosis, treatment, and monitoring and provide a novel clinical antitumour therapeutic strategy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available