Article
Chemistry, Multidisciplinary
Man-Di Wang, Gan-Tian Lv, Hong-Wei An, Ni-Yuan Zhang, Hao Wang
Summary: This study reports a programmable peptide molecule that enables specific and efficient assembly by binding to targeting receptor proteins. By designing different peptide sequences and receptor bindings, it is possible to promote oligomerization and functional regulation of protein complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, Research & Experimental
Xiaona Chen, Binbin Xie, Lingling Huang, Jianqin Wan, Yuchen Wang, Xiaowei Shi, Yiting Qiao, Haihan Song, Hangxiang Wang
Summary: A new class of self-assembled drug cocktails, formed through a one-pot process, shows promising therapeutic synergy in preclinical cancer models, producing durable recession in tumor growth. The self-assembled CD NAs offer a scalable and cost-effective methodology for drug delivery without the need for carrier matrices.
Article
Chemistry, Multidisciplinary
Guanying Li, Xunwu Hu, Pingping Nie, Dingze Mang, Shi Jiao, Shijin Zhang, Sona Rani Roy, Sachie Yukawa, Shunsuke Asahina, Hiroaki Sugasawa, William Cortes, Zhaocai Zhou, Ye Zhang
Summary: The study introduced a molecular self-assembly technology that selectively halts cancer cell proliferation by inactivating the oncoprotein YAP. This technology targets the accumulation of ALPP and utilizes nanostructures specifically on lipid rafts of ovarian cancer cells to exert potent anti-proliferative effects.
Article
Chemistry, Multidisciplinary
Zhengqing Guo, Hui He, Yi Zhang, Jiaming Rao, Tao Yang, Ting Li, Lu Wang, Mengke Shi, Mengya Wang, Shihong Qiu, Xue Song, Hengte Ke, Huabing Chen
Summary: This study demonstrates the use of self-assembled micellar nanoarchitecture for potent phototherapy against triple-negative breast cancer, showing efficient suppression against primary, metastatic, and recurrent TNBC through tunable photoconversion and cytoplasmic translocation.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zijian Zhou, Chao Du, Qianyu Zhang, Guocan Yu, Fuwu Zhang, Xiaoyuan Chen
Summary: By modulating the self-assembly of drug amphiphiles EB-CPT with the anticancer drug PTX, ultrahigh quality nanovesicles (NVs) were produced with high drug loading efficiency and content. The ECX NVs with EB-CPT:PTX weight ratio of 1:2 exhibited remarkable anticancer activity against cancer cells and improved tumor inhibition effect in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Yi Lai, Fenglin Li, Zhifeng Zou, Madiha Saeed, Zhiai Xu, Haijun Yu
Summary: This article explores the development and applications of amyloid polypeptide-based nanostructures in biotechnological applications. It emphasizes the importance of thermodynamic and kinetic factors in self-assembly and summarizes cutting-edge advances and challenges in engineering amyloid peptide nanomaterials.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Biomedical
Hao Zhang, Zhilong Wang, Tongxin Gao, Zhongyan Wang, Chunhua Ren, Jianfeng Liu
Summary: By using an in situ enzyme-instructed self-assembly system, the targeted inhibition of lactate efflux and consumption was achieved, inducing tumor acidosis apoptosis for cancer selective therapy.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Anouk Martin, Pierre Lalanne, Amelie Weber-Vax, Angela Mutschler, Sebastien Lecommandoux
Summary: The self-assembly of PEG-b-PTMC copolymers into vesicles, also known as polymersomes, was evaluated using microfluidic systems. Two microfluidic chips with different flow regimes were used to investigate the impact of process conditions on vesicle formation. A solvent exchange approach was developed to allow direct use of the polymersomes in biological evaluation. The size of the polymersomes was influenced by the total flow rate and copolymer concentration, but not by the organic/aqueous solvent ratio.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Zhen Zou, Libei He, Xiangxi Deng, Huangxiang Wang, Ziyun Huang, Qian Xue, Zhihe Qing, Yanli Lei, Ronghua Yang, Juewen Liu
Summary: The study reports the formation of Zn2+-driven RNA self-assembly forming spherical nanoparticles, while preserving the integrity and biological function of RNA, with excellent RNA-loading efficiency, pharmacokinetics, and bioavailability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Zhe Wang, Fenghua Meng, Zhiyuan Zhong
Summary: Targeted drug delivery systems play a crucial role in enhancing the efficacy of ovarian cancer treatment, improving selectivity, overcoming drug resistance, and reducing toxicity. These systems provide important means to explore innovative treatment modalities.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Qiuhong Zhang, Meijuan He, Xiaodong Zhang, Hongwei Yu, Jiawei Liu, Yi Guo, Junmin Zhang, Xiangzhong Ren, Han Wang, Yanli Zhao
Summary: This study reports the development of a tumor microenvironment-activable ROS-generating system using a protein-based nanomedicine that undergoes multistage self-assembly. The system offers effective self-protection for normal tissues and achieves tumor-specific therapy, providing a powerful strategy for nanomedicine design and precise cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Li-Han Liu, Xian-Zheng Zhang
Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Miaojuan Qiu, Junzong Chen, Xiuyu Huang, Binbin Li, Shiqiang Zhang, Peng Liu, Qiang Wang, Zhi Rong Qian, Yihang Pan, Yu Chen, Jing Zhao
Summary: This study successfully achieved synergistic treatment for intraperitoneally disseminated ovarian cancer by using RGD-modified amorphous calcium phosphate loaded with doxorubicin. The engineered calcium-involved nanomedicine augmented the therapeutic effect of doxorubicin and showed favorable anti-tumor effects in an experimental model.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Siyuan Zeng, Bin Lan, Xiaofan Ren, Shuman Zhang, Daniel Schreyer, Markus Eckstein, Hai Yang, Nathalie Britzen-Laurent, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Isabella Kutschick, Susanne Pfeffer, Peter Bailey, Andrew Biankin, Robert Gruetzmann, Christian Pilarsky
Summary: The study identifies CDK7 as a potential therapeutic target for overcoming chemoresistance in pancreatic cancer. Inhibition or knockout of CDK7 induces cell cycle arrest, apoptosis, and DNA damage, and shows synergistic therapeutic effects with gemcitabine and paclitaxel.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Ondrej Sedlacek, Valentin Bardoula, Elina Vuorimaa-Laukkanen, Lars Gedda, Katarina Edwards, Aurel Radulescu, Grigoriy A. Mun, Yong Guo, Junnian Zhou, Hongbo Zhang, Veronique Nardello-Rataj, Sergey Filippov, Richard Hoogenboom
Summary: This study provides an in-depth analysis of micelles based on amphiphilic gradient copolymers and compares them to diblock copolymer micelles as potential drug delivery systems. The results show that gradient copolymers can provide stable drug nanoformulations with comparable drug loadings to block copolymer systems and benefit from easier synthesis.
Article
Chemistry, Multidisciplinary
Tianqi Wang, Yanan Fu, Shengjie Sun, Chenyi Huang, Yunfei Yi, Junqing Wang, Yang Deng, Meiying Wu
Summary: This review summarizes the important role of exosomes, such as extracellular vesicles, in cell-to-cell communication, especially in the tumor microenvironment, where exosomes serve as key pathways for the transfer of proteins, nucleic acids, and small molecules between different types of cells. The applications of exosomes as drug delivery systems in cancer therapy are classified based on the cell source of the exosomes, including normal cells, immune cells, and tumor cells. Different modifications of exosomes and methods of drug loading are presented. Finally, the challenges that hinder the clinical translation of exosomes are discussed.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Mingming Han, Jingjing Yao, Jiwu Huang, Yan Tang, Xianwen Wu, Bingan Lu, Jiang Zhou
Summary: Aqueous rechargeable Zn//MnO2 batteries are a promising candidate for future energy storage systems due to their economic and environmental advantages. However, poor reaction kinetics and capacity degradation hinder the performance of Zn//MnO2 batteries. This study demonstrates that defects engineering and phase transformation can enhance ion/charge transfer kinetics and structural stability, leading to a high discharge capacity of 285 mAh/g and capacity retention of 81% after 500 cycles in the aqueous Zn//A-MnO2 system.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou, Huile Gao
Summary: Decades have passed since the approval of the first nanoparticles-based medicine for human cancer treatment, and research and development in nanoparticles for drug delivery have been continuing. Today, there have been significant advancements in nanoparticles, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines, and nano-antibodies. These nanoparticles have shown great potential in the treatment and diagnosis of challenging diseases such as cancer and neurodegenerative diseases, making them promising drug carriers and therapeutic agents in the future.
CHINESE CHEMICAL LETTERS
(2023)
Review
Cell Biology
Yonghui Lv, Meiying Wu, Zhe Wang, Junqing Wang
Summary: Ferroptosis is a regulated cell death caused by iron-dependent lipid peroxide accumulation. The imbalance of intracellular oxidative systems and antioxidant systems is the main cause, regulated by a complex network. Cancer cells with resistance to apoptosis and chemotherapeutics are prone to ferroptosis, making it a potential strategy for eliminating cancer cells. Ferroptosis is also linked to other diseases such as neurological disorders and ischemia-reperfusion injury, providing new insights for clinical treatment.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Chemistry, Physical
Baohua Zhang, Meiying Wu, Liang Zhang, Yun Xu, Weidong Hou, Huazhang Guo, Liang Wang
Summary: In this study, a one-step carbonization strategy was designed to synthesize Co nanoparticles supported on N-doped carbon nanotubes (Co/CNT) with excellent bifunctional electrocatalytic performance. The Co/CNT material exhibited long-term durability in the oxygen reduction reaction and oxygen evolution reaction, and was successfully applied in a rechargeable Zn-air battery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Daiyun Xu, Xu Chen, Yongxiao Li, Zhidong Chen, Wanting Xu, Xinpei Wang, Yonghui Lv, Zhe Wang, Meiying Wu, Gang Liu, Junqing Wang
Summary: Nanodiscs (NDs) formed by apoA-I peptides can be designed with different diameters through varying factors such as the number of tandem repeats, sequence composition, and lipid-to-APA ratio. Proline is dispensable for APA-ND formation, but its substitution can induce smaller NDs and larger NDs depending on the lipid ratio. Proline-tryptophan residues play a dominant role in forming larger NDs. Molecular simulation analysis shows that enriched basic and acidic residues in APAs enhance the structural stability of APA-NDs through hydrogen-bond and salt bridge networks.
Article
Oncology
Yunzhi Pan, Jing Liu, Yingyin Gao, Yuqing Guo, Changxing Wang, Zhipan Liang, Meiying Wu, Yulan Qian, Yinyan Li, Jingyi Shen, Chenchen Lu, Sai Ma
Summary: This study aimed to investigate the functional significance and underlying mechanism of FBXW7 loss of function in esophageal squamous cell carcinoma (ESCC). The results showed that FBXW7 loss of function led to the activation of the MAPK signaling pathway and upregulation of MMP3 and VEGFA, promoting tumor cell proliferation, invasion, and migration. MAP4 was identified as a potential target of FBXW7. FBXW7 loss of function was associated with tumor stage and shorter survival in ESCC patients. The FBXW7/MAP4/ERK axis may be a promising target for ESCC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Liu Yu, Mian Yu, Wei Chen, Shengjie Sun, Wenxin Huang, Tianqi Wang, Zhangwen Peng, Zewen Luo, Yixuan Fang, Yongjiang Li, Yang Deng, Meiying Wu, Wei Tao
Summary: This paper reports on a separable cancer vaccine, FeSHK@B-ovalbumin (OVA), based on bioadhesive nanoparticles (BNPs), which targets multi-epitope antigens and exhibits effective cancer immunotherapy. The FeSHK@B-OVA nanorocket initiates satellite-rocket separation in the acidic tumor microenvironment, leading to intracellular oxidative stress amplification. The prolonged drug retention within the tumor tissue triggers immunogenic cell death and enables robust antigen-specific antitumor immunity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Immunology
Jie Chen, Junchi Xu, Yayan Niu, Lin Yao, Xuanmiao Liu, Hui Chen, Siyi Chen, Meiying Wu, Xin Yu, Ping Xu
Summary: This study investigates the relationship between LAG-3 and active tuberculosis. The expression of LAG-3 is increased on CD8+T cells in active tuberculosis patients and is associated with sputum culture results. Furthermore, the elevated expression of LAG-3 on CD8+T cells correlates with functional defects and severity of pulmonary TB. Blocking LAG-3 signaling restores the function of CD8+T cells.
MICROBIAL PATHOGENESIS
(2023)
Article
Biochemical Research Methods
Yunfei Yi, Chan Feng, Mian Yu, Lin Mei, Meiying Wu, Wei Tao
Summary: Efficient gene delivery in an integrated drug delivery system is crucial for multimodal antitumor therapy. This study presents a protocol for constructing a peptide-based siRNA delivery system that achieves tumor vascular normalization and gene silencing in 4T1 cells. The system highlights four major steps and has the potential to silence gene expression and perform other treatments based on different peptide segments.
Article
Cell Biology
Yue Li, Meiying Wu, Xinyu Xing, Xingxing Li, Congchong Shi
Summary: This study investigates the repair process of dentin-pulp injuries and identifies the crucial role of the Wnt10a/beta-catenin signaling pathway in promoting the proliferation and odontoblast differentiation of dental pulp stem cells (DPSCs). The activation of this pathway significantly contributes to the repair process of different types of dentin-pulp injuries.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
Correction
Chemistry, Multidisciplinary
Ting Chen, Weiwei Zeng, Yuanqi Liu, Mian Yu, Chenyi Huang, Zhaoqing Shi, Chuchu Lin, Jia Tang, Lin Mei, Meiying Wu
Correction
Multidisciplinary Sciences
Yun Zhou, Mian Yu, Changjun Tie, Yang Deng, Junqing Wang, Yunfei Yi, Fan Zhang, Chenyi Huang, Hairong Zheng, Lin Mei, Meiying Wu
Review
Pharmacology & Pharmacy
Zhe Wang, Xinpei Wang, Wanting Xu, Yongxiao Li, Ruizhi Lai, Xiaohui Qiu, Xu Chen, Zhidong Chen, Bobin Mi, Meiying Wu, Junqing Wang
Summary: Biomimetic delivery systems (BDSs) are a groundbreaking paradigm in nanomedicine inspired by the designs of biological systems. They offer targeted delivery, minimized side effects, and enhanced therapeutic outcomes. However, their translation to clinical applications faces challenges in reproducibility, physiological stability, and rigorous efficacy and safety evaluations. Collaborative interdisciplinary research and reevaluation of regulatory frameworks are necessary for successful clinical translation.
Article
Cell Biology
Yue Li, Meiying Wu, Xinyu Xing, Xingxing Li, Congchong Shi
Summary: This study investigates the repair process of dentin-pulp injuries and the role of the Wnt10a/ss-β-catenin signaling pathway. The activation of this pathway was found to promote proliferation and odontoblast differentiation of dental pulp stem cells. The findings contribute to a better understanding of the mechanisms involved in dentin-pulp injury repair and provide new insights for future studies on tooth regeneration.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
