Article
Medicine, General & Internal
Megumi Maeda, Haruhisa Fukuda, Ryu Matsuo, Fumi Kiyuna, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi
Summary: This study aimed to elucidate nationwide trends in reperfusion therapy utilization and subsequent 30-day mortality in acute ischemic stroke patients in Japan. The analysis found that the use of IV rt-PA and EVT increased over time, while the extension of the IV rt-PA therapeutic time window did not lead to a higher risk of post-reperfusion mortality.
Review
Clinical Neurology
Shao-Hua Yang, Ran Liu
Summary: The ischemic penumbra, defined four decades ago, plays a crucial role in the battleground of ischemic stroke. Therapies such as rt-PA thrombolytic therapy and mechanical thrombectomy are pivotal in treating acute ischemic stroke, with brain imaging techniques providing guidance for reperfusion therapy. The dynamic nature of the ischemic penumbra highlights the importance of timely intervention and the development of future treatment strategies for ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Changyi Wang, Ting Cui, Lu Wang, Qiange Zhu, Anmo Wang, Ye Yuan, Zilong Hao, Bo Wu
Summary: The study found that in acute ischemic stroke patients receiving reperfusion therapy, those with higher UA levels had a better outcome at 3 months, while those with a greater decrease in UA levels were more likely to have a poor outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yunyun Xiong, Ajay K. Wakhloo, Marc Fisher
Summary: The treatment of acute ischemic stroke is advancing with intravenous thrombolysis, mechanical thrombectomy, and cytoprotection being investigated. Later treatment with alteplase and the use of tenecteplase are beneficial alternatives to alteplase. Cytoprotection as an adjunct to reperfusion has shown no efficacy in prior clinical trials, but may have potential benefits.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Sine Mette Ogendahl Buus, Marie Louise Schmitz, Pia Cordsen, Soren Paaske Johnsen, Grethe Andersen, Claus Ziegler Simonsen
Summary: Despite having tax-funded universal healthcare, there are socioeconomic inequalities in reperfusion treatment rates among ischemic stroke patients.
Article
Clinical Neurology
Federico Di Maria, Maeva Kyheng, Arturo Consoli, Jean-Philippe Desilles, Benjamin Gory, Sebastien Richard, Georges Rodesch, Julien Labreuche, Jean-Baptiste Girot, Cyril Dargazanli, Gaultier Marnat, Bertrand Lapergue, Romain Bourcier
Summary: This study found that a strategy combining thrombectomy and thrombo-aspiration was more effective than other strategies in achieving the first-pass effect. Clinical outcomes were better in patients with first-pass effect compared to non-first-pass effect patients.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Haryadi Prasetya, Lucas A. Ramos, Thabiso Epema, Kilian M. Treurniet, Bart J. Emmer, Ido R. van den Wijngaard, Guang Zhang, Manon Kappelhof, Olvert A. Berkhemer, Albert J. Yoo, Yvo B. E. W. M. Roos, Robert J. van Oostenbrugge, Diederik W. J. Dippel, Wim H. van Zwam, Aad van der Lugt, Bas A. J. M. de Mol, Charles B. L. M. Majoie, Ed van Bavel, Henk A. Marquering
Summary: The study introduces a semi-automated quantitative reperfusion measure, qTICI, which provides a similar prognostic value for functional outcome compared to eTICI score. It was found that in adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Alis J. Dicpinigaitis, Steven D. Shapiro, Rolla Nuoman, Haris Kamal, Philip Overby, Gurmeen Kaur, Ji Y. Chong, Johanna T. Fifi, Neha Dangayach, Eliza C. Miller, Shadi Yaghi, Fawaz Al-Mufti
Summary: Population-level data from the United States over a twenty-year period show that intravenous thrombolysis treatment for pediatric AIS patients is associated with high rates of favorable outcomes without an increased risk of hemorrhagic transformation.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Chemistry, Multidisciplinary
Minkyung Kim, Jungju Oh, Youngki Lee, Eun-Hye Lee, Seung Hwan Ko, Ji Hoon Jeong, Chang Hwan Park, Minhyung Lee
Summary: In this study, self-replicating mRNA (Rep-mRNA) was developed using a replicon system to prolong gene expression for the treatment of ischemic stroke. The Rep-mRNA/DA-PEI complex showed higher and longer expression of HO1 compared to other complexes, leading to decreased apoptosis and infarct size in an animal model of ischemic stroke.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Shanshan Liu, Jianpei Xu, Yipu Liu, Yang You, Laozhi Xie, Shiqiang Tong, Yu Chen, Kaifan Liang, Songlei Zhou, Fengan Li, Zhuang Tang, Ni Mei, Huiping Lu, Xiaolin Wang, Xiaoling Gao, Jun Chen
Summary: This study proposes a strategy called nanobuffer to protect the penumbra from the detrimental factors and damage caused by ischemia-reperfusion injury. The nanobuffer, composed of poly(lactic-co-glycolic acid) nanoparticles coated with neutrophil membrane and decorated with alpha-lipoic acid and cannabidiol, effectively neutralizes the detrimental factors and provides neuroprotection. The systematic evaluations demonstrate significant reduction of detrimental factors, decrease in infarct volume, and improved neurological recovery compared to the untreated group of stroke rats.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Clinical Neurology
Elena Spronk, Gina Sykes, Sarina Falcione, Danielle Munsterman, Twinkle Joy, Joseph Kamtchum-Tatuene, Glen C. Jickling
Summary: Hemorrhagic transformation is a common complication in acute ischemic stroke patients, with factors such as stroke severity, reperfusion therapy, hypertension, hyperglycemia, and age increasing the risk. Inflammation and the immune system play important roles in BBB disruption and HT, with therapies targeting these pathways being potential strategies to reduce the risk of HT.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Longfei Wu, Ming Wei, Bohao Zhang, Bowei Zhang, Jian Chen, Sifei Wang, Leilei Luo, Shuling Liu, Sijie Li, Changhong Ren, David C. Hess, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study investigated the safety and tolerability of direct ischemic postconditioning (IPostC) in both a dog model and patients with acute ischemic stroke treated with thrombectomy, and found it to be safe, feasible, and tolerable.
Article
Clinical Neurology
Anna Ramos-Pachon, Elena Lopez-Cancio, Alejandro Bustamante, Natalia Perez de la Ossa, Monica Millan, Maria Hernandez-Perez, Teresa Garcia-Berrocoso, Pere Cardona, Marta Rubiera, Joaquin Serena, Xavier Ustrell, Moises Garces, Mikel Terceno, Antoni Davalos, Joan Montaner
Summary: Through studying acute ischemic stroke patients, early D-dimer levels were identified as an independent predictor of LVO, which may help optimize prehospital patient transport to the appropriate stroke center.
Article
Endocrinology & Metabolism
Xiaoshuang Li, Liping Lin, Jian Zhang, Yuhua Fan, Shihui Xing, Li Jiang, Zhiyun Yang, Jing Zhao, Jingjing Li
Summary: This study examined the association between unfavorable venous outflow (VO) and microvascular function in acute ischemic stroke patients. It found that unfavorable VO is associated with cerebral edema and impaired microvascular integrity. Patients with unfavorable VO had higher levels of extravascular-extracellular volume fraction in the infarct core and a lower percentage of robust arterial collateral circulation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Ting Cui, Changyi Wang, Qiange Zhu, Shucheng Li, Yuan Yang, Anmo Wang, Xuening Zhang, Wenzuo Shang, Bo Wu
Summary: This study aimed to investigate the association between neutrophil percentage-to-albumin ratio (NPAR) and the 3-month functional outcome in patients with acute ischemic stroke (AIS) who received reperfusion therapy. The results showed that NPAR was positively associated with poor functional outcome, with higher NPAR values indicating a higher risk of poor outcome. These findings can provide guidance for the treatment and prognosis assessment of AIS patients.
FRONTIERS IN NEUROLOGY
(2022)