Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair

BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients

(2015) A Laroche-Clary et al.   BRITISH JOURNAL OF CANCER

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

(2015) Kirsten Lauber et al.   CANCER LETTERS

Biodosimetry Based on γ-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated Radiotherapy

(2015) Sebastian Zahnreich et al.   RADIATION RESEARCH

Activity of trabectedin in germline BRCA1/2-mutated metastatic breast cancer: results of an international first-in-class phase II study

(2014) S. Delaloge et al.   ANNALS OF ONCOLOGY

Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2014)   ANNALS OF ONCOLOGY

Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells

(2014) Chun-Han Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis

(2014) Mateusz Rytelewski et al.   Molecular Oncology

Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: results of a worldwide expanded access program study

(2013) B. L. Samuels et al.   ANNALS OF ONCOLOGY

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Outcome of metastatic breast cancer in selected women with or without deleterious BRCA mutations

(2013) S. Bayraktar et al.   CLINICAL & EXPERIMENTAL METASTASIS

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

γ-H2AX and other histone post-translational modifications in the clinic

(2012) Christophe E. Redon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Correlation ofTP53andMDM2genotypes with response to therapy in sarcoma

(2012) Hege O. Ohnstad et al.   CANCER

Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner

(2012) Stefan C. Genet et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chemosensitivity and outcome of BRCA1- and BRCA2-associated ovarian cancer patients after first-line chemotherapy compared with sporadic ovarian cancer patients

(2011) P. M. L. H. Vencken et al.   ANNALS OF ONCOLOGY

ERCC5/XPG, ERCC1, and BRCA1 gene status and clinical benefit of trabectedin in patients with soft tissue sarcoma

(2011) Antoine Italiano et al.   CANCER

Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: A retrospective multicentric study

(2011) P. Schöffski et al.   EUROPEAN JOURNAL OF CANCER

Homologous recombination research is heating up and ready for therapy

(2011) S. N. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

(2011) P. M. Krawczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality assurance for clinical studies in regional deep hyperthermia

(2011) Gregor Bruggmoser et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

(2010) G. Germano et al.   CANCER RESEARCH

Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study

(2010) Rolf D Issels et al.   LANCET ONCOLOGY

A Review of Trabectedin (ET-743): A Unique Mechanism of Action

(2010) Maurizio D'Incalci et al.   MOLECULAR CANCER THERAPEUTICS

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro radiosensitisation by trabectedin in human cancer cell lines

(2008) Jesús Romero et al.   EUROPEAN JOURNAL OF CANCER

Hyperthermia adds to chemotherapy

(2008) Rolf D. Issels   EUROPEAN JOURNAL OF CANCER

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER