Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice

N-Propargyl caffeate amide (PACA) prevents cardiac fibrosis in experimental myocardial infarction by promoting pro-resolving macrophage polarization

(2020) Yuanyuan Cheng et al.   Aging-US

Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice

(2019) Jia Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Glucose-regulated protein 78 substrate-binding domain alters its conformation upon EGCG inhibitor binding to nucleotide-binding domain: Molecular dynamics studies

(2018) K. R. D. Sagara N. S. Gurusinghe et al.   Scientific Reports

Repurposing drugs to target the malaria parasite unfolding protein response

(2018) Yun Chen et al.   Scientific Reports

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

(2017) Yinliang Zhang et al.   Molecular Metabolism

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis

(2016) Ehab A Ayaub et al.   JOURNAL OF PATHOLOGY

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view

(2016) Michael J. Pagliassotti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI)

(2016) Jia Zhao et al.   MOLECULAR NEUROBIOLOGY

N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway

(2015) Chuanbin Yang et al.   ACS Chemical Neuroscience

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Celastrol identified as a leptin sensitizer and potential novel treatment for obesity

(2015) Claire Greenhill   Nature Reviews Endocrinology

Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?

(2015) Yuanyuan Cheng et al.   Oxidative Medicine and Cellular Longevity

Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism

(2014) Chaoyun Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting endoplasmic reticulum stress in metabolic disease

(2013) Stewart Siyan Cao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells

(2013) JINZHI LU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice

(2013) Jung Eun Kim et al.   PLoS One

Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I

(2013) Simmy Thomas et al.   PLoS One

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GRP78 plays an essential role in adipogenesis and postnatal growth in mice

(2012) Genyuan Zhu et al.   FASEB JOURNAL

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography–mass spectrometry

(2011) Oswald Quehenberger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Celastrol Inhibits Tat-Mediated Human Immunodeficiency Virus (HIV) Transcription and Replication

(2011) Vivek Narayan et al.   JOURNAL OF MOLECULAR BIOLOGY

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

(2010) Sarah Hummasti et al.   CIRCULATION RESEARCH

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice

(2009) Maaike H. Oosterveer et al.   PLoS One