Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation

Potential Contributions of the Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) in the Pathogenesis of Steatohepatitis in a Chronic Plus Binge Rat Model of Alcoholic Liver Disease

(2015) V. Zabala et al.   ALCOHOL AND ALCOHOLISM

Lycopene Attenuated Hepatic Tumorigenesis via Differential Mechanisms Depending on Carotenoid Cleavage Enzyme in Mice

(2014) B. C. Ip et al.   Cancer Prevention Research

Lycopene and Apo-10′-lycopenoic Acid Have Differential Mechanisms of Protection against Hepatic Steatosis in β-Carotene-9′,10′-oxygenase Knockout Male Mice

(2014) Blanche C Ip et al.   JOURNAL OF NUTRITION

Lycopene Metabolite, Apo-10'-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet-Promoted Hepatic Inflammation and Tumorigenesis in Mice

(2013) B. C. Ip et al.   Cancer Prevention Research

Development of ferret as a human lung cancer model by injecting 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

(2013) Koichi Aizawa et al.   LUNG CANCER

Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention

(2013) Blanche Ip et al.   Nutrients

Lycopene metabolism and its biological significance

(2012) Xiang-Dong Wang   AMERICAN JOURNAL OF CLINICAL NUTRITION

Additive Effects of Nicotine and High-Fat Diet on Hepatic Steatosis in Male Mice

(2012) Theodore C. Friedman et al.   ENDOCRINOLOGY

Lung carcinogenesis by tobacco smoke

(2012) Stephen S. Hecht   INTERNATIONAL JOURNAL OF CANCER

Apo-10'-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice

(2012) Jayong Chung et al.   JOURNAL OF NUTRITION

Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer

(2011) Ma. Reina Improgo et al.   BIOCHEMICAL PHARMACOLOGY

 -Cryptoxanthin Supplementation Prevents Cigarette Smoke-Induced Lung Inflammation, Oxidative Damage, and Squamous Metaplasia in Ferrets

(2011) C. Liu et al.   Cancer Prevention Research

Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period

(2011) Ayaka Hamabe et al.   JOURNAL OF GASTROENTEROLOGY

NNK-Induced Lung Tumors: A Review of Animal Model

(2011) Hua-Chuan Zheng et al.   Journal of Oncology

Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1

(2009) Hongwei Yuan et al.   JOURNAL OF HEPATOLOGY

Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity

(2008) Petros Nikolaos Karamanakos et al.   ARCHIVES OF TOXICOLOGY

Enzymatic metabolites of lycopene induce Nrf2‐mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

(2008) Fuzhi Lian et al.   INTERNATIONAL JOURNAL OF CANCER

Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats

(2008) Yan Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis

(2008) Richard D. Egleton et al.   TRENDS IN PHARMACOLOGICAL SCIENCES