Article
Engineering, Environmental
Hui Yu, Haoyi Zhao, Yujie Zhang, Yuemin Hou, Runqing Li, Ting Liang, Yuanyuan Zhang, Cheng Li, Jingjie Zhao, Mingzhen Zhang, Ruifang An
Summary: Choriocarcinoma is a malignancy caused by abnormal proliferation and invasion of trophoblastic cells. A novel approach of nanoparticle-based antineoplastic drug delivery can overcome drug resistance and side effects. The cancer cell membrane-coated biomimetic nanoreactor (MMC) developed by the researchers effectively targeted tumor cells and showed significant anticancer effects in cell lines and animal models.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Weiling Miao, Yang Liu, Jian Tang, Tiandong Chen, Fang Yang
Summary: In this study, magnetic liposomes loaded with both moexitecan and superparamagnetic iron oxide nanoparticles (SPIO) were fabricated and shown to have a mean diameter of 180-200 nm with a round morphology. Cell toxicity, in vitro cell uptake, and in vivo fluorescence imaging experiments demonstrated that Mex@MLipo was the most effective in killing HT-29 cells compared with HepG-2 and PC-3 cells, due to its ability to combine chemotherapy and induce ferroptosis.
Article
Chemistry, Multidisciplinary
Jundong Lin, Huikang Yang, Yixun Zhang, Fen Zou, Huichan He, Wenjie Xie, Zhihao Zou, Ren Liu, Qianfeng Xu, Jie Zhang, Guowei Zhong, Yuejiao Li, ZhenFeng Tang, Yulin Deng, Shanghua Cai, Linyao Wang, Yugang Huang, Yangjia Zhuo, Xinqing Jiang, Weide Zhong
Summary: Combining chemotherapy with the induction of ferroptosis is a potential new oncotherapy. In this study, a polymeric nanoparticle, mPEG-b-PPLGFc@Dox, was synthesized to decrease the toxicity of doxorubicin (Dox) and enhance the efficacy of chemotherapy by combining it with the induction of ferroptosis. The results showed that mPEG-b-PPLGFc@Dox not only had higher antitumor efficacy but it also reduced the damage to normal tissue.
Article
Engineering, Biomedical
Fengying Shao, Yafeng Wu, Zhaoyan Tian, Songqin Liu
Summary: By constructing biomimetic nanoreactors disguised as cancer cell membranes, a synergistic cancer starvation therapy and cascade amplified hypoxia activated chemotherapy were achieved, resulting in significant inhibition of tumor growth and improved therapeutic efficacy.
Correction
Oncology
Tongsen Zheng, Jiabei Wang, Xuan Song, Xianzhi Meng, Shangha Pan, Hongchi Jiang, Lianxin Liu
Summary: There was a misplaced image in Fig.4a in the original article.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Sotoudeh Mohammadi, Zahra Heidar, Masoumeh Mirzamoradi, Zatollah Asemi
Summary: Combination chemotherapy is a beneficial option for cancer patients, but its effectiveness varies. Doxorubicin, a commonly used chemotherapy drug, has serious side effects. Studies suggest that melatonin may serve as an adjuvant to enhance the antitumor effects of Doxorubicin and mitigate its adverse reactions.
Article
Biochemistry & Molecular Biology
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Sotoudeh Mohammadi, Zahra Heidar, Masoumeh Mirzamoradi, Zatollah Asemi
Summary: Combination chemotherapy can be beneficial for some cancer patients, but not always effective. Doxorubicin is a commonly used chemotherapy drug with serious side effects. Melatonin, a potential anticancer agent, may enhance the antitumor effects of doxorubicin and reduce its side effects.
Article
Engineering, Biomedical
Jingchen Wang, Jian Yang, Kang Liu, Jiayu Yuan, Yijie Shi, Hongdan Li, Liang Zhao
Summary: Glioma is a common and aggressive primary brain tumor in adults. The development of a biomimetic nanovesicle loaded with doxorubicin and ultra-small iron nanoparticles showed promising results in targeted delivery of the drug and improved anticancer efficacy in the treatment of glioma.
MATERIALS TODAY BIO
(2023)
Article
Biophysics
Shuang Fu, Yinan Zhao, Jiao Sun, Ting Yang, Defu Zhi, Enxia Zhang, Fangli Zhong, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: RGD-modified liposomes showed excellent active targeting ability for integrin ?v?3 receptors and enhanced DOX release due to their pH-sensitivity, resulting in significant antitumor efficacy with low toxicity. This new approach provides a potential avenue for improved tumor therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Ye Yuan, Chunyu Tian, Qi Wang, Xinyu Qiu, Yufang Wang, Hulin Jiang, Jifu Hao, Yujing He
Summary: Ferroptosis can cause cell death through excessive accumulation of lipid peroxide (LPO) and has potential for cancer therapy. However, efficient strategies are facing challenges due to insufficient H2O2, high pH value, and high redox level of tumor cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qi Jiang, Mengchun Chen, Xuewei Yang, Deli Zhuge, Qingqing Yin, Dongyan Tian, Li Li, Xufei Zhang, Wenbin Xu, Shuangshuang Liu, Fan Li, Cuiye Weng, Yijing Lin, Haonan Wang, Dapang Rao, Yiming Chen, Qiangjun Cai, Linzhi Yan, Ledan Wang, Fang Wang, Xiaosheng Lu, Bin Wen, Yingzheng Zhao, Feng Zhang, Weiliang Xia, Haiyan Zhu, Yijie Chen
Summary: Researchers have developed a biomimetic nanoparticle that can enhance the effectiveness of chemotherapy drugs for cancer treatment while reducing their toxicity. This nanoparticle can selectively target healthy tissue and prevent the drug from damaging healthy cells, enabling higher drug doses to be delivered to tumor tissue without toxicity. The nanoparticle also activates the immune system to attack tumors. In mouse tumor models, pretreatment with this nanoparticle followed by high-dose chemotherapy significantly prolonged survival.
Review
Oncology
Malvi Savani, Katti Woerner, Lihong Bu, Mark Birkenbach, Keith M. Skubitz
Summary: Pegylated liposomal doxorubicin (PLD) is a unique formulation of doxorubicin with lower toxicity profile than free doxorubicin, mainly causing hand-foot syndrome without alopecia, nausea, myelosuppression, or cardiotoxicity. This case highlights a lesser known toxicity of PLD and raises concerns about potential long-term toxicities with other liposomal drugs.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Xinru Kong, Zhijing He, Yu Zhang, Yuelin Fang, Dongzhu Liu, Hang Wu, Jianbo Ji, Yanwei Xi, Lei Ye, Xiaoye Yang, Guangxi Zhai
Summary: This study developed a tumor-specific nanoplatform, p-LDM, for the delivery of doxorubicin (DOX) and activation of combined ferroptosis and apoptosis. The nanoplatform was constructed by coating a ferric metal-organic framework (MOF) with liposomes, which were further modified with targeting peptides and enzyme-activatiable cell-penetrating peptides (CPPs) for tumor-specific penetration. The MOF components, Fe3+ and terephthalic acid (H2BDC), triggered ferroptosis of tumor cells. Combining DOX and ferroptosis activation, p-LDM showed potent direct killing effect, immune cell death, T cell activation, and dendritic cell maturation promotion. Moreover, the combination with CD47-SIRPα blockade therapy further enhanced ferroptosis and remodeled the tumor immune microenvironment, resulting in superior inhibition of tumor growth, metastasis, and recurrence.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Medicine, Research & Experimental
Kento Kannaka, Kohei Sano, Masayuki Munekane, Toshihide Yamasaki, Masayori Hagimori, Takahiro Mukai
Summary: Accelerated drug release from liposomes in tumor tissue was achieved using a bio-orthogonal IEDDA reaction. The combination of DOX-encapsulated HSTz-liposomes with NBCOOH showed significantly suppressed tumor growth compared to conventional DOX-encapsulated liposomes.
MOLECULAR PHARMACEUTICS
(2022)