Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Near-Infrared-II Nanoparticles for Cancer Imaging of Immune Checkpoint Programmed Death-Ligand 1 and Photodynamic/Immune Therapy

(2021) Qiang Liu et al.   ACS Nano

Design strategy and recent progress of fluorescent probe for noble metal ions (Ag, Au, Pd, and Pt)

(2021) Mengyao She et al.   COORDINATION CHEMISTRY REVIEWS

Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

(2021) Jiao Chen et al.   ACS Sensors

Molecular Engineered Squaraine Nanoprobe for NIR-II/Photoacoustic Imaging and Photothermal Therapy of Metastatic Breast Cancer

(2020) Defan Yao et al.   ACS Applied Materials & Interfaces

Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter

(2020) Jian Du et al.   ACS Applied Materials & Interfaces

Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations

(2020) Kun Dou et al.   ANALYTICAL CHEMISTRY

Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness

(2020) Huilong Ma et al.   CHEMISTRY OF MATERIALS

Comparison of benzothiazole-based dyes for sensitive DNA detection

(2020) Yanying Wang et al.   CHINESE CHEMICAL LETTERS

Single Wavelength Laser Excitation Ratiometric NIR-II Fluorescent Probe for Molecule Imaging in Vivo

(2020) Xiaoguang Ge et al.   ANALYTICAL CHEMISTRY

Organic Spherical Nucleic Acids Facilitate NIR‐II Emitting Dye to Cross Blood‐Brain Barrier

(2020) Fan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

(2020) Yuanyuan Li et al.   Nature Communications

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

(2020) Zhijun Zhang et al.   ADVANCED MATERIALS

A Tumor‐Microenvironment‐Responsive Lanthanide–Cyanine FRET Sensor for NIR‐II Luminescence‐Lifetime In Situ Imaging of Hepatocellular Carcinoma

(2020) Mengyao Zhao et al.   ADVANCED MATERIALS

Activatable Nanocomposite Probe for Preoperative Location and Intraoperative Navigation for Orthotopic Hepatic Tumor Resection via MSOT and Aggregation-Induced Near-IR-I/II Fluorescence Imaging

(2020) Zhuo Zeng et al.   ANALYTICAL CHEMISTRY

NIR‐II Chemiluminescence Molecular Sensor for In Vivo High‐Contrast Inflammation Imaging

(2020) Yanling Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorination Chemistry Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

(2020) Ye Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

(2020) Fan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rearrangement regulated cysteine fluorescent probe for cellular oxidative stress evaluation induced by copper(II)

(2020) Na Zhou et al.   CHINESE CHEMICAL LETTERS

A general strategy to quantify analytes through fluorescence chromaticity and luminosity

(2020) Tianyu Liang et al.   CHINESE CHEMICAL LETTERS

Molecular engineering of ultra-sensitive fluorescent probe with large Stokes shift for imaging of basal HOCl in tumor cells and tissues

(2020) Peng Lu et al.   CHINESE CHEMICAL LETTERS

Planar plus twisted molecular structure leads to high brightness of semiconducting polymer nanoparticles for NIR-IIa fluorescence imaging

(2020) Shunjie Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photophysical Tuning of Shortwave Infrared Flavylium Heptamethine Dyes via Substituent Placement

(2020) Monica Pengshung et al.   ORGANIC LETTERS

Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

(2020) Benhao Li et al.   Nature Communications

Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

(2020) Guanjun Deng et al.   ACS Nano

In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation

(2020) Shengliang Li et al.   ACS Nano

Incorporation of Planar Blocks into Twisted Skeletons: Boosting Brightness of Fluorophores for Bioimaging beyond 1500 Nanometer

(2020) Shunjie Liu et al.   ACS Nano

An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics

(2020) Lanqing Li et al.   ADVANCED MATERIALS

Bright and Stable NIR‐II J‐aggregated AIE Dibodipy for Dynamic in vivo Bioimaging

(2020) Fan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for in vivo High‐Contrast Bioimaging

(2020) Xiao-Bing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm

(2020) Yu Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing

(2020) Lingfei Lu et al.   Nature Communications

Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates

(2020) Zonghai Sheng et al.   Research

Self-assembled AIEgen nanoparticles for multiscale NIR-II vascular imaging

(2020) Yaxi Li et al.   BIOMATERIALS

NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles

(2020) Dandan Chen et al.   NANO LETTERS

Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

(2020) Hui Zhou et al.   Nature Communications

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

(2019) Shangfeng Wang et al.   Nature Communications

A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

(2019) Xiao Luo et al.   CHINESE CHEMICAL LETTERS

Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring

(2019) Dandan Li et al.   ANALYTICAL CHEMISTRY

Polypeptide-Conjugated Second Near-Infrared Organic Fluorophore for Image-Guided Photothermal Therapy

(2019) Tuanwei Li et al.   ACS Nano

All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy

(2019) Qi Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Stable, Wavelength-Tunable Fluorescent Dyes in the NIR-II Region for In Vivo High-Contrast Bioimaging and Multiplexed Biosensing

(2019) Zuhai Lei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR‐II Fluorescence and Photoacoustic Imaging

(2019) Bing Guo et al.   ADVANCED MATERIALS

FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe

(2019) Yueyue Li et al.   CHINESE CHEMICAL LETTERS

Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

(2019) Shuai Gao et al.   Nature Communications

Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics

(2019) Rui Tian et al.   Science Advances

Monitoring the Real‐Time Circulatory System‐Related Physiological and Pathological Processes In Vivo Using a Multifunctional NIR‐II Probe

(2019) Daifeng Li et al.   ADVANCED FUNCTIONAL MATERIALS

Lighting Up NIR-II Fluorescence in Vivo: An Activable Probe for Noninvasive Hydroxyl Radical Imaging

(2019) Wenqi Feng et al.   ANALYTICAL CHEMISTRY

Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release

(2019) Ben Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Renal-clearable Molecular Semiconductor for Second Near-Infrared Fluorescence Imaging of Kidney Dysfunction

(2019) Jiaguo Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural modification of BODIPY: Improve its applicability

(2019) Mengdi Liu et al.   CHINESE CHEMICAL LETTERS

Ratiometric sensing lysosomal pH in inflammatory macrophages by a BODIPY-rhodamine dyad with restrained FRET

(2019) Yu Yan et al.   CHINESE CHEMICAL LETTERS

J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

(2019) Caixia Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging

(2019) Shunjie Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Nanoaggregate Probe for Breast Cancer Metastasis through Multispectral Optoacoustic Tomography and Aggregation-Induced NIR-I/II Fluorescence Imaging

(2019) Juan Ouyang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota

(2019) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging

(2019) Zhe Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe

(2018) Weizhi Wang et al.   ADVANCED MATERIALS

Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region

(2018) Ji Qi et al.   ADVANCED MATERIALS

“Dual Lock-and-Key”-Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near-Infrared Window

(2018) Yufu Tang et al.   ADVANCED MATERIALS

Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors

(2018) Zonghai Sheng et al.   ADVANCED MATERIALS

3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates

(2018) Shoujun Zhu et al.   ADVANCED MATERIALS

An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging

(2018) Benhao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission

(2018) Ge Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aptamer based fluorescent probe for serum HER2-ECD detection: The clinical utility in breast cancer

(2018) Meiling Wang et al.   CHINESE CHEMICAL LETTERS

Biomarker-targeted fluorescent probes for breast cancer imaging

(2018) Dongfang Yue et al.   CHINESE CHEMICAL LETTERS

Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

(2018) Qinglai Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

(2018) Yao Sun et al.   Chemical Science

Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery

(2018) Kangquan Shou et al.   Chemical Science

A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

(2018) Hao Wan et al.   Nature Communications

Recent Advances of Optical Imaging in the Second Near-Infrared Window

(2018) Kenry et al.   ADVANCED MATERIALS

Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy

(2018) Ben Shi et al.   NANO LETTERS

Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

(2018) Nuernisha Alifu et al.   ACS Nano

Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window

(2018) Chunyan Li et al.   ACS Nano

Bio-Erasable Intermolecular Donor-Acceptor Interaction of Organic Semiconducting Nanoprobes for Activatable NIR-II Fluorescence Imaging

(2018) Yufu Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Developing a Bright NIR‐II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD‐L1

(2018) Hao Wan et al.   ADVANCED FUNCTIONAL MATERIALS

A red-emitting water-soluble fluorescent probe for biothiol detection with a large Stokes shift

(2018) Lei Yang et al.   CHINESE CHEMICAL LETTERS

50 & 100 Years Ago

(2017)   NATURE

Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window

(2017) Shoujun Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore

(2017) Yi Feng et al.   Chemical Science

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

(2017) Alexander L. Antaris et al.   Nature Communications

Near-infrared fluorophores for biomedical imaging

(2017) Guosong Hong et al.   Nature Biomedical Engineering

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

(2016) Xiao-Dong Zhang et al.   ADVANCED MATERIALS

Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer

(2016) Yao Sun et al.   Chemical Science

Aggregation-Induced Emission: Together We Shine, United We Soar!

(2015) Ju Mei et al.   CHEMICAL REVIEWS

Biological imaging without autofluorescence in the second near-infrared region

(2015) Shuo Diao et al.   Nano Research

A small-molecule dye for NIR-II imaging

(2015) Alexander L. Antaris et al.   NATURE MATERIALS

Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window

(2014) Guosong Hong et al.   Nature Communications

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

(2013) Zhimin Tao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

(2013) Nicholas G. Horton et al.   Nature Photonics

Near-Infrared Fluorescent Dye-Doped Semiconducting Polymer Dots

(2011) Yuhui Jin et al.   ACS Nano

PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect

(2010) Sarbari Acharya et al.   ADVANCED DRUG DELIVERY REVIEWS

New Generation of Multifunctional Nanoparticles for Cancer Imaging and Therapy

(2009) Kyeongsoon Park et al.   ADVANCED FUNCTIONAL MATERIALS

A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

(2009) Kevin Welsher et al.   Nature Nanotechnology

Second window for in vivo imaging

(2009) Andrew M. Smith et al.   Nature Nanotechnology

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE