Article
Cell & Tissue Engineering
Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang
Summary: This study found that adding an unrelated umbilical cord blood unit to haploidentical hematopoietic stem cell transplantation can improve the prognosis and enhance the graft versus leukemia effect without increasing the incidence of graft versus host disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Guangyu Sun, Baolin Tang, Kaidi Song, Yue Wu, Meijuan Tu, Xiang Wan, Wen Yao, Liangquan Geng, Ping Qiang, Xiaoyu Zhu
Summary: This study compared the outcomes of UCBT and MST in the treatment of adult B-ALL patients. The results showed that UCBT had slower hematopoietic recovery but lower incidence of extensive cGVHD. The NRM, relapse, DFS, and GRFS were comparable between MST and UCBT recipients, but UCBT showed better OS for patients with long-term survival.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Mike Winstead, Memphis Hill, Zarreen Amin, Mark Vander Lugt, Xiaohua Chen, Paul Szabolcs
Summary: The recovery of GDT clonality is an early part of immunological recovery after stem cell transplantation. Severe graft-versus-host disease patients have lower GDT clonality post-transplantation and show abnormal expression of gene 82. Further studies may determine if abnormal GDT spectratype can predict the clinical manifestations of graft-versus-host disease.
Review
Cell & Tissue Engineering
Gabriela Sanchez-Petitto, Katayoun Rezvani, May Daher, Hind Rafei, Partow Kebriaei, Elizabeth J. Shpall, Amanda Olson
Summary: Umbilical cord blood transplantation is an attractive alternative source of hematopoietic stem cells, with unique immune tolerance and engraftment kinetics. It has a lower risk of GvHD and comparable clinical outcomes to bone marrow transplantation. However, limitations in cell numbers and delayed engraftment pose challenges for its wider application. Research is being conducted to address these limitations and explore the potential of cord blood in treating various disorders.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Pediatrics
Roisin Borrill, Kay Poulton, Robert Wynn
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) using cord blood as a source of stem cells has been proven to be an effective treatment for acute leukemia in children. Cord blood T-cells have unique immunological characteristics and have shown superior efficacy in eradicating malignancy. However, the procedure is associated with increased transplant-related mortality and morbidity.
FRONTIERS IN PEDIATRICS
(2023)
Review
Medicine, General & Internal
Diana Vanegas, Laura Nino-Quiroga, Mauricio Chaparro, Bernardo Camacho-Rodriguez, Marcela Estupinan, Ana-Maria Perdomo-Arciniegas
Summary: The translated article discusses the main issues associated with using unrelated umbilical cord blood and haploidentical grafts as alternative donors, emphasizing that selecting the best donor depends on various factors.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Cell & Tissue Engineering
Elisha Purcell, Timothy Nguyen, Madeleine Smith, Tayla Penny, Madison C. B. Paton, Lindsay Zhou, Graham Jenkin, Suzanne L. Miller, Courtney A. McDonald, Atul Malhotra
Summary: This study systematically reviewed the effects of UCBCs on brain outcomes in animal models of perinatal brain injury. It found differential benefits of UCBCs across different subgroups, such as greater efficacy in IVH model compared to HI model, UCB-MSCs compared to UCB-MNCs, and local administrative routes compared to systemic routes. However, the study identified a serious risk of bias and overall low certainty of evidence.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Review
Immunology
Xiaoxiao Xu, Xiaoqin Li, Yanmin Zhao, He Huang
Summary: Histone deacetylase inhibitors are the focus of extensive research for their potential in treating immune-mediated diseases like GVHD while preserving beneficial effects on GVL. These drugs may become novel therapies by modifying gene expression and immune cell function to prevent or treat GVHD and other immune conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng, Shaoyan Hu
Summary: This study investigated the impact of umbilical cord blood co-infusion on graft-versus-host disease (GVHD) in pediatric patients receiving haplo-HSCT for severe aplastic anemia (SAA) in China. The results showed that haplo-cord HSCT group had lower incidences of II-IV acute GVHD and chronic GVHD compared to the haplo HSCT group.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2022)
Article
Immunology
Yan Jiang, Jie Zhao, Minghui Wang, Fang Huang, Jiaqi Li, Rui Liu, Jiangbo Wan, Siguo Hao
Summary: This study demonstrates that MEXs exert their effects by inhibiting the immunomodulatory function of DCs, macrophages, and T lymphocytes, aiding in alleviating GVHD symptoms and preserving the antitumor effects of CD8+ T lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Jiasheng Wang, Leland Metheny
Summary: Cord blood is an important source for allogeneic hematopoietic cell transplantation and is also being developed for cell therapy products. The unique cellular composition of cord blood, including higher percentages of hematopoietic stem cells and progenitor cells, offers advantages in immune tolerance and off-the-shelf cell therapy development. In addition, cord blood-derived mesenchymal stem cells have potential in regenerative medicine and inflammatory/autoimmune conditions. This review focuses on recent clinical development of cord blood-derived therapies in oncology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xin-Yu Li, Li-Ping Zhan, Dian-Dian Liu, Xia-Wei Han, Han Chen, Zheng-Zhou Wu, Yin Wang, Li-Ping Que, Xiao-Jun Wu, Su Liu, Kai-Mei Wang, Shao-Liang Huang, Jian-Pei Fang, Ke Huang, Hong-Gui Xu
Summary: Using posttransplant cyclophosphamide (PTCY) as a method for controlling peri-engraftment syndrome (PES) and prophylaxis against graft-versus-host disease (GvHD) in single-unit umbilical cord blood transplantation (UCBT) for children with acute leukemia is safe and effective. Higher doses of PTCY may be more suitable for GvHD prophylaxis in UCBT patients.
Article
Immunology
Elisabeth Meedt, Andreas Hiergeist, Andre Gessner, Katja Dettmer, Gerhard Liebisch, Sakhila Ghimire, Hendrik Poeck, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Ernst Holler, Daniela Weber
Summary: The decrease of butyrogenic commensals after allogeneic stem cell transplantation is associated with increased severity of graft-vs-host disease and increased transplantation-related mortality.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Meteorology & Atmospheric Sciences
Gang Liu, Tongxin Li, Xiaoyu Zhu, Shuyu Wang, Jianping Tang
Summary: A wind gust parameterization scheme combined with the WRF model was used to simulate and project gust wind speed in China. The study compared historical and future gust wind speeds to investigate their long-term change under a warming climate. The results showed that the gust wind speeds in China overall changed slightly with little response to future warming.
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xiaoyu Zhu, Yongqian Zhang, Bomin Xie, Junhui Miao, Wei Ma, Jun Liu, Lixiang Wang
Summary: In this study, two NIR-absorbing small molecule electron acceptors, FM3 and FM4, with high stability were developed using an all-fused-ring strategy. The band gaps of FM3 and FM4 could be continuously reduced to 1.44 eV and 1.33 eV, respectively, causing the absorption redshift to the NIR region. Both FM3 and FM4 exhibited excellent photo, thermal, and chemical stability, leading to high power conversion efficiencies (PCEs) of 11.4% in organic solar cells. This work highlights the strong potential of all-fused-ring molecules in the development of high-stability NIR-absorbing opto-electronic devices.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Manman Xu, Yincheng Chang, Guanghui Zhu, Xiaoyu Zhu, Xiaotong Song, Jie Li
Summary: Immunotherapy has revolutionized clinical tumor therapy, but low response rates in cold tumors due to the complex tumor microenvironment persist. A novel nanosystem, RBC@Mn-MOF/PPI, was developed to enhance cGAS/STING-mediated antitumor immunity and transform cold tumors into hot ones. This engineered system effectively remodels the immune-suppressive TME, activates immune cells, and targets primary and metastatic tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Hematology
Zhen Peng, Xiaoyu Zhu, Chongwei Wang, Mingfeng Zhou, Xiaoling Xu, Yin Chen
Summary: This study assessed the effects of depression and anxiety on hemophilia patients enrolled in clinical trials and identified risk factors. The results showed that hemophilia patients in clinical trials have significant anxiety and depression, and the frequency of acquiring medical information and baseline scores are risk factors for anxiety and depression.
ANNALS OF HEMATOLOGY
(2023)
Correction
Hematology
Dongyao Wang, Zimin Sun, Xiaoyu Zhu, Xiaohu Zheng, Yonggang Zhou, Yichen Lu, Peidong Yan, Huiru Wang, Huilan Liu, Jing Jin, Huaiping Zhu, Rui Sun, Yi Wang, Binqing Fu, Zhigang Tian, Haiming Wei
Article
Biochemistry & Molecular Biology
Tao Zhou, Di Jia, Jiahui Han, Ce Xu, Xiaohong You, Xin Ge
Summary: In this study, it was found that HDAC6 inhibition can alleviate lung dysfunction and tissue damage in the APE rat model by blocking the AKT/ERK signaling pathway, providing new theoretical fundamentals for APE therapy.
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
(2023)
Article
Computer Science, Hardware & Architecture
Wei Shi, Wei Xu, Xiaohu You, Chunming Zhao, Kejun Wei
Summary: This article provides a tutorial overview of intelligent reflection communication (IRC) technologies, including reconfigurable intelligent surface (RIS) and ambient backscatter communication (AmBC), to support the requirements of Internet-of-Everything (IoE) applications. The benefits of IRC-assisted IoE in space-air-ground integrated communications and green communications are elaborated, along with the potential for enhancing IoE security. Numerical results highlight the importance of IRC in unfavorable secrecy environments.
IEEE WIRELESS COMMUNICATIONS
(2023)
Article
Oncology
Dan Liu, Furong Kou, Jifang Gong, Zhiqiang Wang, Xiaotian Zhang, Jian Li, Yan Li, Jie Li, Jun Zhou, Ming Lu, Xicheng Wang, Zhihao Lu, Yanshuo Cao, Jianjun Zou, Xiaoyu Zhu, Ruihua Xu, Lin Shen
Summary: This study aimed to evaluate the use of pyrotinib in the treatment of pretreated HER2-positive gastric cancer patients, and the results showed acceptable toxicities for both pyrotinib alone and in combination with docetaxel.
Article
Engineering, Biomedical
Haiwei Liang, Yanxiao Ao, Wenjing Li, Kaini Liang, Baixue Tang, Junyang Li, Jianwei Wang, Xiaoyu Zhu, Yanan Du
Summary: This study aimed to assemble biomimetic 3D BM microniches by co-culturing HSPCs and MSCs, and transplant them into the BM cavity for the treatment of h-ARS. The results showed that these BM microniches can prolong the maintenance of HSPCs, promote hematopoietic reconstitution, and alleviate death from acute lethal radiation. Furthermore, the Notch signaling pathway plays a significant role in maintaining HSPCs.
BIOACTIVE MATERIALS
(2023)
Article
Microbiology
Xiao-Yu Zhu, Yang Li, Chun-Xu Xue, Ian D. E. A. Lidbury, Jonathan D. Todd, David J. Lea-Smith, Jiwei Tian, Xiao-Hua Zhang, Jiwen Liu
Summary: This study revealed the unique genetic potential and enzymatic capabilities of Bacteroidetes in utilizing complex polysaccharides in the deep sea. Compared to surface waters, deep-sea Bacteroidetes exhibited a greater utilization of algal and plant cell wall polysaccharides, such as hemicellulose and pectin. The findings suggest that sinking cell wall debris from the photic zone can serve as an important carbon source for deep-sea heterotrophs, shaping their communities and metabolism.
Article
Meteorology & Atmospheric Sciences
Xiaoyu Zhu, Yijia Hu, Xuguang Sun, Zhong Zhong, Yao Ha, Yunying Li
Summary: The occurrence and movement of Meiyu rain belt in 2020 are influenced by atmospheric forcings from different directions, and the contributions from different directions change with time. The understanding of the mechanisms behind Meiyu can be improved through the analysis of the contributions and roles of atmospheric forcings.
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Xinjiang Xia, Wenfei Sun, Yang Liu, Dongming Wang, Junhui Zhao, Zhi Zhang, Xiaohu You
Summary: This paper investigates a cell-free massive MIMO with network-assisted full-duplex system for ultra-reliable and low-latency communications through joint optimization of duplex mode selection and transceiver design. An optimization problem is proposed to maximize the achievable sum rates for the system under finite blocklength, with constraints on data rates and transmission power. A concave-convex procedure algorithm is utilized to solve this problem. Simulation results demonstrate that the proposed algorithm outperforms traditional co-frequency co-time full-duplex and half-duplex schemes.
2023 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE, WCNC
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Weiliang He, Cheng Zhang, Juan Deng, Qingbi Zheng, Yongming Huang, Xiaohu You
Summary: With the widespread use of massive MIMO technology in wireless networks, network optimization becomes more expensive due to increased angular space. Digital twin (DT) is a potential tool to enhance performance evaluation, but it faces challenges in optimizing massive MIMO due to complex channel characteristics and system performance uncertainty. In this article, a conditional generative adversarial network (C-GAN) based digital twin network (DTN) is proposed to fit the mapping between beamforming and system performance and match the performance distribution across different UE positions.
2023 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE, WCNC
(2023)
Article
Optics
Boquan Ren, Hongguang Wang, Milivoj R. Belic, Yongdong Li, Xiaoyu Zhu, Yiqi Zhang
Summary: Applying strain in photonic graphene can induce zero-energy edge states, which can be understood as a stack of Su-Schrieffer-Heeger chains.
Article
Cell Biology
Yin Liu, Xiu-Zhi Zhu, Yi Xiao, Song-Yang Wu, Wen-Jia Zuo, Qiang Yu, A-Yong Cao, Jun-Jie Li, Ke-Da Yu, Guang-Yu Liu, Jiong Wu, Tao Sun, Jiu-Wei Cui, Zheng Lv, Hui-Ping Li, Xiao-Yu Zhu, Yi-Zhou Jiang, Zhong-Hua Wang, Zhi-Ming Shao
Summary: Triple-negative breast cancer is a heterogeneous disease with limited treatment options. The results of the FUTURE trial show that subtype-based therapy may improve outcomes in metastatic TNBC patients, with objective responses achieved in nearly 30% of patients. This study also provides insights into the association between genomic and clinicopathological parameters and treatment efficacy.