Article
Biochemistry & Molecular Biology
Guohua Hou, Yuan Li, Qimeng Wang, Huijuan Zhang, Shuang Liang, Bin Liu, Wenbiao Shi
Summary: This study developed a nanocomposite that can co-deliver Cur and Mel for potential treatment of solid tumors. The nanocomposite incorporated the advantages of each component, such as efficient compound loading, improved cellular uptake, tumor accumulation, and synergistic anti-tumor effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Ruan, Chunjing Zhang, Kai Zhao
Summary: The study found that N-2-Hydroxypropyl trimethyl ammonium chloride chitosan/N, O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) showed good immunogenicity and no toxicity as a universal vaccine adjuvant/delivery system. The prepared N-2-HACC/OVA/CMCS NPs induced higher levels of antibodies and immune responses in mice, suggesting their potential in enhancing humoral, cellular, and mucosal immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Sourour Idoudi, Takwa Bedhiafi, Fairooz Sahir, Yousef Hijji, Shahab Uddin, Maysaloun Merhi, Said Dermime, Nashiru Billa
Summary: This study evaluated the anti-cancer activity of curcumin nanoparticles (CUR-NPs) and succinylated curcumin nanoparticles (CUR.SA-NPs) on colon cancer cell lines. The nanoparticles showed dose and time-dependent cytotoxicity, inducing apoptosis through activation of Caspase signaling. Based on their promising attributes and in vitro results, further investigation into the role of these nanoparticle formulations in CRC management is warranted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Supakarn Hansapaiboon, Bryan Paul Bulatao, Feuangthit Niyamissara Sorasitthiyanukarn, Pongsakorn Jantaratana, Nonthaneth Nalinratana, Opa Vajragupta, Pranee Rojsitthisak, Pornchai Rojsitthisak
Summary: This study demonstrates the effectiveness of magnetic-guide targeting in delivering CUR-2GE-Ch-IONPs for the treatment of triple-negative breast cancer.
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin, Kai Zhao
Summary: This report presents the encapsulation of amoxicillin in N-2-Hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles for biomedical applications. The synthesized nanoparticles demonstrated sustained drug release, good cytocompatibility and broad-spectrum antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Aldo Y. Tenorio-Barajas, Maria de la L. Olvera, Gabriel Romero-Paredes, Victor Altuzar, Efrain Garrido-Guerrero, Claudia Mendoza-Barrera
Summary: This work proposes a modified method using microfluidics combined with the microemulsion technique to manufacture chitosan nanoparticles. The synthesized nanoparticles showed improved size control and distribution compared to batch synthesis. The total encapsulation of IgG protein was confirmed during the fabrication of chitosan/IgG-loaded nanoparticles. The proposed materials have the potential to be used as carrier-delivery systems.
Article
Polymer Science
Mahmoud H. Abu Elella, Demiana H. Hanna, Riham R. Mohamed, Magdy W. Sabaa
Summary: This study investigates the challenges and solutions for protein delivery in the gastrointestinal (GI) tract. The results show that the prepared interpolyelectrolyte complex has good biocompatibility properties based on cytotoxicity studies.
Review
Pharmacology & Pharmacy
Julie Frigaard, Janicke Liaaen Jensen, Hilde Kanli Galtung, Marianne Hiorth
Summary: Nanotechnology has found unique applications in drug delivery, cosmetics, fabrics, water treatment, and food packaging. Chitosan, a nanoparticle derived from natural polysaccharide chitin, has gained attention in modern medicine for its unique properties. This review examines the cytotoxicity of chitosan nanoparticles in biomedical research, revealing low cytotoxicity regardless of particle composition or assay method. However, thorough characterization and cytotoxicity assessment are recommended for new chitosan derivatives and compositions before market implementation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Polymer Science
Yu Kang, Zhi Liu, Yingyun Long, Baolong Wang, Xu Yang, Di Sha, Kai Shi, Xiangling Ji, Bai Li, Yonggang Liu
Summary: A two-step method was used to synthesize N,N,N-trimethyl chitosan (TMC) from chitosan, with molecular weight ranging from 29 to 136 kg/mol and quaternization degree from 70% to 82%. Size exclusion chromatography (SEC) coupled with multiangle laser light scattering was employed to analyze the molecular weight and chain conformation, showing a significant increase in chain flexibility upon N-methylation, possibly due to the breakage of intramolecular hydrogen bonds between chitosan repeating units.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Applied
Sen Li, Hongyan Lv, Yu Chen, Hongdong Song, Yu Zhang, Shuo Wang, Lei Luo, Xiao Guan
Summary: This study developed vitexin-loaded bilayer nanoparticles to improve the bioavailability of vitexin. The nanoparticles protected vitexin from release in the stomach and promoted sustained release in the intestine. Furthermore, the nanoparticles increased the antioxidant activity of vitexin.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Shafi Ullah, Abul Kalam Azad, Asif Nawaz, Kifayat Ullah Shah, Muhammad Iqbal, Ghadeer M. Albadrani, Fakhria A. Al-Joufi, Amany A. Sayed, Mohamed M. Abdel-Daim
Summary: Nanoparticles have a crucial role in cancer treatment by delivering drugs specifically to malignant cells and avoiding damage to normal cells. In this study, folic acid-modified chitosan nanoparticles were successfully formulated for colon cancer treatment, and their properties, drug release, and cytotoxicity were investigated.
Article
Biochemistry & Molecular Biology
Kessily B. Rufato, Paulo R. Souza, Ariel C. de Oliveira, Sharise B. R. Berton, Roberta M. Sabino, Edvani C. Muniz, Ketul C. Popat, Eduardo Radovanovic, Matt J. Kipper, Alessandro F. Martins
Summary: This study demonstrates that polysaccharide-based polyelectrolyte multilayers prepared using the layer-by-layer approach can provide stability and durability for free-standing gels, as well as antimicrobial properties and cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Peththa Wadu Dasuni Wasana, Hasriadi, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat, Pranee Rojsitthisak
Summary: In this study, metformin and curcumin were co-encapsulated into chitosan/alginate nanoparticles using response surface methodology. The optimized nanoparticles displayed stability, sustained release of the drugs, enhanced mucoadhesion, and improved cellular uptake. Furthermore, the nanoparticles exhibited better anti-inflammatory effects and pain relief compared to the physical mixture of the drugs, without significant side effects in mice. This study establishes the efficacy and safety of a chitosan/alginate nanodelivery system for the combination of metformin and curcumin against pain.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Ali Mohammadi, Hossein Danafar
Summary: Cancer is a common cause of death worldwide and curcumin is a natural anticancer therapeutic with limited or no negative effects. However, its therapeutic applications are limited due to its hydrophobic nature and poor bioavailability. In this study, Bovine Serum Albumin-Coated Copper Sulfide nanoparticles were synthesized for curcumin drug delivery. The nanoparticles were characterized and their release pattern, hemotoxicity, and cytotoxicity were investigated. The results showed that the synthesized nanoparticles had a high CUR loading and its release was dependent on pH. The nanoparticles exhibited no toxicity and could be considered as a suitable candidate for drug delivery.
Article
Food Science & Technology
Ozi Adi Saputra, Wahyu Nur Safitriono, Dyah Ellyawati Kusumaningtyas Maharani, Amalia Febiana, Fajar Rakhman Wibowo
Summary: This study aims to overcome the limitations of curcumin by formulating a nano-emulsion called curcumin emulsion (CE) and encapsulating it within chitosan-assembled mesoporous silica nanoparticles (Chi@SiO2@CE). The CE exhibited strong antioxidant activity compared to curcumin alone, and the Chi@SiO2@CE showed pH-controlled release behavior, indicating potential as a pH-responsive drug delivery material.
Article
Polymer Science
Giovanna Amaral Filipe, Victoria Akemi Itakura Silveira, Marcelly Chue Goncalves, Rayanne R. Beltrame Machado, Celso Vataro Nakamura, Cristiani Baldo, Suzana Mali, Renata Katsuko Takayama Kobayashi, Maria Antonia P. Colabone Celligoi
Summary: This study aims to develop biodegradable films based on cassava starch, pullulan, and sophorolipids for the treatment of skin infections. By adding sophorolipids and citric acid, the properties of the films were modified, resulting in antimicrobial effects. The results of the study show that these films can inhibit the growth of common skin pathogens.
Article
Polymer Science
Flavia Amanda Pedroso de Morais, Ana Carolina Vieira De Oliveira, Rodolfo Bento Balbinot, Danielle Lazarin-Bidoia, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Goncalves, Wilker Caetano, Celso Vataru Nakamura
Summary: Biotin, spermine, and folic acid were covalently linked to the F127 copolymer to form a drug delivery system for treating B16F10 cells with HY-loaded PDT. Spectroscopy and spectrophotometric techniques were used to analyze the chemical structures and binders quantification. The hydrophobicity of the binders was found to affect the physicochemical parameters such as critical micelle concentration, critical micelle temperature, size, polydispersity, and zeta potential. The modification with spermine resulted in less changes in the physical and chemical parameters of the micelles.
Article
Polymer Science
Alessandra Ruyz Medeiros, Fabiana da Silva Lima, Andressa Giombelli Rosenberger, Douglas Cardoso Dragunski, Edvani Curti Muniz, Eduardo Radovanovic, Josiane Caetano
Summary: This study aimed to use electrospinning to obtain PBAT/PLA polymer fibers with semiconductors TiO2-R and Fe3O4 to enhance the photocatalytic degradation of environmental contaminants. The parameters used in electrospinning were a needle to target distance of 12 cm, a flow rate of 1 mL h(-1), and a voltage of 14 kV. The best mass ratio of semiconductors in the fibers was determined to be 10% TiO2-R and 1% Fe3O4 at pH 7.0. Characterization techniques such as SEM, DSC, XRD, TGA, and FTIR confirmed the presence of TiO2-R and Fe3O4 in the fibers and their interaction with the polymers, leading to changes in crystallinity and degradation temperature. The fibers exhibited a 64.0% efficiency in degrading Reactive Red 195 dye within 24 hours, indicating potential for photocatalytic degradation of environmental contaminants.
Article
Biochemistry & Molecular Biology
Elisa Parcero Hernandes, Danielle Lazarin-Bidoia, Raquel Dosciatti Bini, Celso Vataru Nakamura, Luiz Fernando Cotica, Sueli De Oliveira Silva Lautenschlager
Summary: In this study, the in vitro effects of iron-oxide magnetic nanoparticles conjugated with the antitumor drug doxorubicin on human breast cancer cells were evaluated. The results showed that these nanoparticles induced cellular redox imbalance and oxidative stress, leading to DNA damage, lipid peroxidation, cell membrane disruption, and loss of mitochondria potential in MCF-7 cells. The association of iron-oxide nanoparticles and doxorubicin may be a potential candidate for anticancer therapy.
Article
Biochemistry & Molecular Biology
Regina G. G. Dare, Elayaraja Kolanthai, Craig J. J. Neal, Yifei Fu, Sudipta Seal, Celso V. V. Nakamura, Sueli O. S. Lautenschlager
Summary: Exposure to ultraviolet radiation can cause photodamage to cellular macromolecules, leading to photoaging and photocarcinogenesis. Cerium oxide nanoparticles (CNPs) exhibit antioxidant activity due to their enzyme-like properties. This study aimed to synthesize CNPs associated with tannic acid (TA) and investigate their photoprotective effects in UVB-exposed L929 fibroblasts.
Article
Biochemistry & Molecular Biology
Aline Pinto Zani, Caroline Pinto Zani, Zia Ud Din, Edson Rodrigues-Filho, Tania Ueda-Nakamura, Francielle Pelegrin Garcia, Sueli de Oliveira Silva, Celso Vataru Nakamura
Summary: In this study, a new synthetic compound A3K2A3 was found to have anti-tumor activity against cervical cancer cells. The potential mechanism of action includes regulation of redox balance, damage to cell membrane and DNA, and inhibition of cell division leading to apoptosis. These findings suggest that A3K2A3 could be a promising alternative for the treatment of cervical cancer.
Article
Virology
Thalita Zago Oliveira, Dyenefer Pereira Fonseca, Andre Henrique dos Santos, Thays Rosa da Silva, Danielle Lazarin-Bidoia, Zia Ud Din, Benedito Prado Dias Filho, Celso Vataru Nakamura, Edson Rodrigues-Filho, Tania Ueda-Nakamura
Summary: We report the in vitro anti-HSV-1 activity of two dibenzylideneketone compounds, DBK1 and DBK2, for the first time. DBK1 demonstrated virucidal activity and caused morphological changes in the HSV-1 envelope. DBK2 reduced HSV-1 plaque size in vitro. The DBKs are promising anti-HSV-1 candidates due to their low toxicity and ability to exert an antiviral effect at the early stages of HSV-1-host cell interaction.
ARCHIVES OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alex Graca Contato, Vanessa Kaplum, Debora Botura Scariot, Francielle Pelegrin Garcia, Hugo Falzirolli, Fabio Vandresen, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Cleuza Conceicao da Silva, Celso Vataru Nakamura
Summary: Leishmaniasis is a tropical disease that affects approximately 1.3 million people annually. Current treatments for this disease have dangerous side effects. This study discovered that a limonene-acylthiosemicarbazide compound (ATZ-S-04) shows promising antiproliferative activity against Leishmania parasites and affects their morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Microbiology
Gabriella Maria Andriani, Lais Fernanda de Almeida Spoladori, Marcieli Fabris, Priscila Goes Camargo, Patricia Morais Lopes Pereira, Jussevania Pereira Santos, Guilherme Bartolomeu-Goncalves, Lais Alonso, Cesar Armando Contreras Lancheros, Antonio Alonso, Celso Vataru Nakamura, Fernando Macedo Jr, Phileno Pinge-Filho, Lucy Megumi Yamauchi, Marcelle de Lima Ferreira Bispo, Eliandro Reis Tavares, Sueli Fumie Yamada-Ogatta
Summary: This study evaluated the effects of the synthetic thiourea derivative BTU-01 on planktonic and sessile cells of Cryptococcus neoformans, and its combination with amphotericin B (AmB). The results showed that BTU-01 exhibited inhibitory activity against C. neoformans cells and had relevant interactions with cryptococcal urease. The combination of BTU-01 and AmB demonstrated synergistic fungicidal activity, without hemolytic activity or cytotoxicity to mammalian cells.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Naiara Cassia Gancedo, Raquel Isolani, Natalia Castelhano de Oliveira, Celso Vataru Nakamura, Daniela Cristina de Medeiros Araujo, Andreia Cristina Conegero Sanches, Fernanda Stumpf Tonin, Fernando Fernandez-Llimos, Danielly Chierrito, Joao Carlos Palazzo de Mello
Summary: This study aimed to synthesize the anticancer and anti-proliferative potential of Limonium species through a systematic review. The results indicate that Limonium species have the potential to be a source of new potential cytotoxic and anticancer agents. However, further research and improved experimental designs are needed to better understand the mechanism of action of these compounds.
Article
Integrative & Complementary Medicine
Carla Maria Mariano Fernandez, Sirlene Adriana Kleinubing, Thaysa Ksiaskiewcz Karam, Fabiana Brusco Lorenzetti, Carolina Trevisolli Palomo, Byanca Pereira Moreira de Oliveira, Odinei Hess Goncalves, Zilda Cristiani Gazim, Mariza Barion Romagnolo, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin de Lima Scodro, Marli Miriam de Souza Lima, Tania Ueda Nakamura, Celso Vataru Nakamura, Benedito Prado Dias Filho
Summary: The present study aimed to develop and characterize solid lipid nanoparticles (SLN-CEPc) and chitosan-coated solid lipid nanoparticles (C-SLN-CEPc) loaded with crude extract of Piper corcovadensis roots. Both formulations showed high encapsulation efficiency, formed a monodispersed system with small and spherical particles, and exhibited promising antimycobacterial activity against Mycobacterium tuberculosis H37Rv. The cytotoxicity testing on Vero cells also indicated low toxicity. The study suggests the potential of nanoencapsulation for the development of new products.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Article
Multidisciplinary Sciences
Karina Miyuki Retamiro, Karine Campos Nunes, Aline Pinto Zani, Caroline Pinto Zani, Laiza Bergamasco Beltran, Sueli de Oliveira Silva, Francielle Pelegrin Garcia, Tania Ueda-Nakamura, Rosangela Bergamasco, Celso Vataru Nakamura
Summary: Ionized water has been found to aid in tissue repair and wound healing. Water purifiers can produce ionized water by using activated charcoal with silver and minerals to reduce contaminants. Additionally, subjecting water to a magnetic field causes a reorganization of water molecules, resulting in alkaline water that has been shown to be non-toxic to mice and can extend survival.
Article
Engineering, Environmental
Elisangela Pacheco da Silva, Vanessa Hafemann Fragal, Elizangela Hafemann Fragal, Thiago Sequinel, Luiz Fernando Gorup, Rafael Silva, Edvani C. Muniz
Summary: Plastic waste consumption has been exponentially increasing every year, posing a significant environmental concern in modern society. Improper disposal of used supercapacitors also leads to serious environmental impacts. Transforming trash into high-valued materials, such as carbon nanomaterial supercapacitors, is a critical action to address these issues.
Article
Chemistry, Medicinal
Jose Rivaldo dos Santos Filho, Rodolfo Bento Balbinot, Celso Vataru Nakamura, Juliana Cristina Castro, Everton da Silva Santos, Jose Eduardo Goncalves, Giani Andrea Linde, Nelson Barros Colauto, Regina Aparecida Correia Goncalves, Arildo Jose Braz de Oliveira
Summary: This study aims to investigate the antileishmanial activity of lipid fractions from mushrooms against Leishmania amazonensis and found that the lipid crude extract and fractions have inhibitory effects on the parasite and are more selective towards the host cells. These results provide a significant basis for further research on the potential use of these fractions in the treatment of leishmaniasis.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Engineering, Biomedical
Somayeh Baghersad, Liszt Y. C. Madruga, Alessandro F. Martins, Ketul C. Popat, Matt J. Kipper
Summary: This study developed an antibacterial polyelectrolyte multilayer (PEM) coating containing a plant-derived condensed tannin polymer. The use of this polymer allowed stable PEM formation and exhibited remarkable antiadhesive and bactericidal properties against Pseudomonas aeruginosa and Staphylococcus aureus.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
