Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 91, Issue -, Pages 568-577Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.05.104
Keywords
Intracellular polysaccharide; Pleurotus eryngii SI-04; Antioxidant and hepatoprotective activity
Funding
- Mushroom Technology System of Shandong Province [SDAIT-07-05]
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In present study, the intracellular polysaccharide (IPS) and its two fractions of IPS-1 and IPS-2 were obtained and purified by DEAE-52 cellulose chromatography from Pleurotus eryngii SI-04 mycelia, and their hepatoprotective effects were also investigated. The results showed that the IPS-2 had superior hepatoprotective effects by increasing the serum enzyme activities and bilirubin (BIL) levels, decreasing the serum albumin (ALB) and triglyceride (TG) levels, improving the hepatic antioxidant status, and ameliorating the hepatic structure damage. Furthermore, the monosaccharide composition and main bond types were also analyzed. These conclusions demonstrated that the both IPS and its fractions might be suitable for functional foods and natural drugs in preventing the acute liver damage. (C) 2016 Elsevier B.V. All rights reserved.
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