Article
Biochemistry & Molecular Biology
Roghayeh Fathi, Reza Mohammadi
Summary: This study developed pH-responsive drug delivery systems for cancer treatment. Magnetic Ag bio nanoparticles were synthesized using Mentha plant extract and incorporated into a hybrid hydrogel. The nanocomposite hydrogels showed controlled drug release in a pH-dependent manner and exhibited high antibacterial and anticancer activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Shaimaa M. M. Nasef, Ehab E. E. Khozemy, Ghada A. A. Mahmoud
Summary: A pH-responsive nanocomposite hydrogel (Cs-g-PAAm/AuNPs) was prepared by grafting chitosan with acrylamide monomer and gold nanoparticles using the gamma irradiation method. The addition of silver nanoparticles to the nanocomposite enhanced the controlled release of the anticancer drug fluorouracil, increased antimicrobial activity, and decreased cytotoxicity. The structure of the nanocomposite was confirmed using FTIR spectroscopy and XRD patterns, and dynamic light scattering revealed the presence of gold and silver nanoparticles in the nanoscale. The nanocomposite hydrogels showed high responsiveness to pH changes and exhibited strong antimicrobial activity.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hossein Ghasemzadeh, Shiravan Afraz, Mohadeseh Moradi, Samira Hassanpour
Summary: The study focuses on the production and characterization of antibacterial and biocompatible films made from chitosan and agarose, as well as the structural analysis of activated agarose. The research demonstrates the potential of these films for applications in food packaging and wound healing due to their strong antibacterial properties against gram-negative and gram-positive bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Hartati Hartati, Subaer Subaer, Hasri Hasri, Teguh Wibawa, Hasriana Hasriana
Summary: The objective of this study is to synthesize and characterize Fe3O4@Chitosan-AgNP nanocomposites and determine their antibacterial activity. The successful synthesis of the nanocomposites was demonstrated, followed by their characterization. The results show the formation of Fe3O4@Chitosan-AgNP nanocomposites and their antibacterial activity.
Article
Biochemistry & Molecular Biology
Xinyu Sun, Mengna Dong, Zhirong Guo, Hui Zhang, Jiao Wang, Pei Jia, Tong Bu, Yingnan Liu, Lihua Li, Li Wang
Summary: In this study, chitosan-copper-gallic acid nanocomposites with dual-functional nanoenzyme characteristics were successfully prepared, showing oxidase-like and peroxidase-like activities that promote the generation of hydrogen peroxide and hydroxyl radicals, leading to excellent antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Naushad Ahmad, Mohammad Rizwan Khan, Subramanian Palanisamy, Sonaimuthu Mohandoss
Summary: This study successfully developed chitosan nanoparticles encapsulated with cisplatin and 5-fluorouracil, which demonstrated antibacterial and anticancer activities. The nanoparticles were able to control and sustain the release of the drugs, and showed significant inhibitory effects on the growth of cancer cells.
Article
Materials Science, Ceramics
Seyed Mousa Mousavi-Kouhi, Abdollah Beyk-Khormizi, Mohammad Sadegh Amiri, Mohammad Mashreghi, Mohammad Ehsan Taghavizadeh Yazdi
Summary: The green method using Verbascum speciosum successfully synthesized Ag-ZnO nanocomposite, which was characterized for its physicochemical properties and exhibited excellent antibacterial and anticancer activities.
CERAMICS INTERNATIONAL
(2021)
Article
Environmental Sciences
Selvam Sathiyavimal, Seerangaraj Vasantharaj, Thamaraiselvi Kaliannan, Hakim AL Garalleh, Mazen Garaleh, Kathirvel Brindhadevi, Nguyen Thuy Lan Chi, Ashutosh Sharma, Arivalagan Pugazhendhi
Summary: In this study, CuO-CS nanocomposite was synthesized using Sida cordifolia aqueous leaf extract and was found to possess antimicrobial activity against both Gram-positive and Gram-negative bacteria. It also exhibited cytotoxic effects on breast cancer and lung cancer cells. Additionally, the nanocomposite showed efficient photocatalytic dye degradation, suggesting its potential applications in biomedical and industrial wastewater treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nuoya Zhao, Weizhong Yuan
Summary: A multi-dynamically crosslinked nanocomposite hydrogel was prepared in this study using dextran modified with aldehyde groups and phenylboronic acid esters, carboxymethyl chitosan, polyaniline grafted chitosan oligosaccharide, and Epigallocatechin Gallate/Ca2+ modified melanin-like nanoparticles. The hydrogel showed good photothermal conversion properties, antioxidant activity, and mechanical properties. It could also record respiratory and heart rate signals in real time and distinguish them accurately using a convolutional neural network algorithm. This multifunctional nanocomposite hydrogel provides a new strategy for promoting chronic wound healing and effective health monitoring.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Kasirajan Kasinathan, Karunakaran Marimuthu, Balaji Murugesan, Selvam Samayanan, Yurong Cai, Chandramohan Rathinam
Summary: The study found that the CS/WS2/Pd composite material exhibits significant antibacterial activity against dangerous bacteria and cell inhibition against MCF-7 breast cancer cells. This new 2D inorganic group may play a crucial role in future cancer treatments.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Yoga Romdoni, Grandprix T. M. Kadja, Yoshitaka Kitamoto, Munawar Khalil
Summary: Incorporating Ag nanoparticles into core-shell Fe3O4@SiO2 offers promising opportunities for biomedical applications. Fe3O4@SiO2-Ag nanoparticles were successfully synthesized using seed-mediated growth methods. The synthesized composite nanoparticles exhibited good crystallinity and a core-shell structure. The nanocomposites also showed superparamagnetic properties and surface plasmon resonance absorption. Moreover, the Fe3O4@SiO2-Ag nanoparticles demonstrated potential antibacterial activity and cytotoxicity against cancer cells, indicating their potential as antibacterial agents and anticancer drug carriers.
APPLIED SURFACE SCIENCE
(2023)
Article
Polymer Science
Abdul Mukheem, Syed Shahabuddin, Noor Akbar, Irfan Ahmad, Kumar Sudesh, Nanthini Sridewi
Summary: The unique structures and multifunctionalities of two-dimensional nanomaterials have attracted increasing interest for constructing novel scaffolds in biomedical applications. In this study, a biocompatible nanocomposite PHA/Ch-WS2 was synthesized and characterized. The results showed significant bactericidal effects of the nanocomposite and no cytotoxicity to human cells, suggesting its potential for biomedical and sanitizing applications.
Article
Chemistry, Physical
Qian Zhang, Hong Zhang, Junjie Ding, Aiping Hui, Xinyue Liu, Aiqin Wang
Summary: Chitosan/palygorskite/glycyrrhizic acid nanocomposite films were successfully prepared and their properties were investigated. The films exhibited excellent physical, mechanical, antibacterial activity, and hemocompatibility, making them suitable for use as wound dressings.
APPLIED CLAY SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Wanying Liu, Zhe Ling, Caoxing Huang, Chenhuan Lai, Qiang Yong
Summary: The study focused on using GM and DC to prepare GM/DC nanocomposite films with superior properties, including high contact angle and tensile strength. These films showed excellent antibacterial properties against various bacteria, especially after adding 60% of DC. Therefore, GM/DC packaging films have great potential as future alternatives to plastic packaging.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Jinghui Jiang, Xiaoxia Chen, Gong-Liang Zhang, Hongshun Hao, Hong-Man Hou, Jingran Bi
Summary: A double-layer nanocomposite film was prepared to improve the mechanical and barrier properties of cellulose and chitosan. The film showed high tensile strength, low permeabilities, and good antibacterial activity. It also exhibited excellent preservation effects in food packaging.
CARBOHYDRATE POLYMERS
(2022)
Article
Neurosciences
Sethuraman Sathya, Boovaragamoorthy Gowri Manogari, Kaliannan Thamaraiselvi, Sethuraman Vaidevi, Kandasamy Ruckmani, Kasi Pandima Devi
Summary: This study evaluated the protective effects of Phytol and Phytol-PLGANPs in a scopolamine-induced model of Alzheimer's disease. The results showed that the consumption of Phytol and Phytol-PLGANPs improved cognitive deficits and enhanced cholinergic effects. These effects were achieved through inhibition of certain enzymes, reduction of oxidative stress, and regulation of apoptotic cell death.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Vaidevi Sethuraman, Narra Kishore, Azeera Mohamed Saliq, Gayathri Loganathan, Ruckmani Kandasamy
Summary: A simple and cost-effective synthesis method was developed for the treatment of lung cancer using pH sensitive-release behaviour of MET@ZIF-8. Analysis of particle size, zeta potential, and HR-TEM showed nanosize spherical morphology of the particles. The release rate of MET was higher at acidic conditions compared to physiological conditions, with pore volume and pore size reduction after MET incorporation in ZIF-8. In-vitro cytotoxicity assay results demonstrated enhanced cytotoxicity for MET@ZIF-8 in a dose-dependent manner.
MATERIALS TECHNOLOGY
(2022)
Article
Chemistry, Physical
C. Ravi Dhas, S. Esther Santhoshi Monica, K. Jothivenkatachalam, A. Joseph Nathanael, V. Kavinkumar, R. Venkatesh, D. Arivukarasan
Summary: The study introduces nickel-copper oxide nanocomposite films as bifunctional electrocatalysts for water splitting, prepared using jet nebulizer spray pyrolysis technique. The synergistic effect between CuO and NiO was found to significantly enhance the performance of the electrocatalyst.
Article
Chemistry, Inorganic & Nuclear
A. Pandiaraj, M. Mohmed Ibrahim, K. Jothivenkatachalam, V. Kavinkumar
Summary: This study focuses on the synthesis of structure-based BiVO4 nanoparticles using the hydrothermal method. The material was characterized using various techniques and showed potential for photoelectrochemical applications.
JOURNAL OF CLUSTER SCIENCE
(2023)
Review
Chemistry, Analytical
Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy, Ruckmani Kandasamy
Summary: In recent decades, the rising human population has led to increased demand for food, prompting agricultural intensification. To protect crops from pests, farmers widely use pesticides, despite the health risks involved. Therefore, it is crucial to develop a specific and efficient method for detecting pesticides in various samples to safeguard human health.
CURRENT ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Ruckmani Kandasamy, Shanmugarathinam Alagarsamy
Summary: The aim of this study was to improve the solubility of zaltoprofen (ZLT) by formulating ZLT loaded polyvinyl pyrrolidone K30 (PVP K30) nanodispersions. Different formulations of ZLT nanodispersions were developed by varying the concentrations of PVP K30 and poloxamer 407. The effects of formulation variables on the properties of ZLT nanodispersions were investigated. The results showed that the developed ZLT nanodispersion (ZLTNDs-4) had small particle size, high drug content, and good anti-inflammatory activity compared to pure ZLT.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Immunology
Krubha Athirathinam, Selvasudha Nandakumar, Shailendra Kumar Verma, Ruckmani Kandasamy
Summary: This study evaluates the use of the biocompatible polymer dextran to improve the shelf-life and biological activity of a thermally unstable plague vaccine protein called LcrV. Analytical techniques and in vivo evaluations demonstrate the structural stability of LcrV protein and its significantly higher immune response when formulated with dextran as compared to the native antigen. Dextran, along with sodium chloride, is proposed as a potential biopolymer to provide compactness and prevent protein unfolding at room temperature for up to three weeks.
Article
Pharmacology & Pharmacy
Gover Antoniraj Mariya, Mohankumar Ramar, Linda Jeeva Kumari Henry, Subramanian Natesan, Ruckmani Kandasamy
Summary: This study presents a novel synthesis method of redox-responsive copolymers using chitosan and methoxy poly-ethylene glycol (mPEG), as well as the formulation of prednisone-loaded nanoparticles (P-NPs) for glutathione (GSH)-responsive release. The specific ligand atrial natriuretic peptide (ANP) was conjugated to the P-NPs (ANP-P-NPs) for targeted drug delivery. Physiochemical characterizations showed that the nanoparticle sizes were below 200 nm, with an entrapment efficiency of 73.89 +/- 0.45% and a zeta potential of approximately -20 mV. The in vitro and in vivo studies demonstrated the potential of these redox-responsive nanoparticles as safe and efficient drug delivery vehicles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Veerappan Kavinkumar, Atul Verma, Kandasamy Jothivenkatachalam, Yen-Pei Fu
Summary: This study presents a microwave-assisted synthesis method to develop CuO-decorated Bi3.84W0.16O6.24/Bi2WO6 dual-functional nanohybrids for electrochemical hydrogen evolution reaction (HER) and photocatalytic Cr(VI) reduction applications. The CuO1.0/biphase-BW catalyst exhibits excellent HER activity in neutral media with a low overpotential and Tafel slope. The CuO1.0/biphase-BW catalyst-coated carbon cloth also demonstrates good conductivity and electrochemical stability. The tremendous activity of the synthesized catalyst is attributed to the formation and electronic interaction of CuO with biphase Bi3.84W0.16O6.24/Bi2WO6, increasing surface-active sites and charge transfer.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
T. V. Dinesh, Beutline Malgija, Mano Ranjana Ponraj, Pavankumar Muralakar, Jesse Joel Thathapudi, Ruckmani Kandasamy, Jeyasankar Alagarmalai, Anna Benedict Balakrishnan, Perumal Samy Ramar, Jannet Vennila James, Jebasingh Bhagavathsingh
Summary: In response to the pandemic crisis caused by the corona virus, researchers have designed pyrimidine-based nucleotides to target the replication targets of SARS-CoV-2. Molecular docking studies indicated that these compounds have good binding affinity, with some outperforming the control drug remdesivir. Molecular dynamics simulation studies further confirmed their stability and non-covalent interactions. Ligand2-BzV_0Tyr showed promising results as it exhibited dual target specificity for both Mpro and RdRp.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Jeseeta Suresh, Nirmal Aravindaraj, Venkateshwaran Krishnaswami, Ruckmani Kandasamy
Summary: The prerequisite for effective drug delivery has increased, leading to extensive exploration of oral film technology (OFT). Oral films dissolve rapidly in the buccal cavity and deliver therapeutic agents into the systemic circulation, enhancing efficacy and bioavailability with minimal toxicity. Their simpler administration mode increases patient compliance, even in non-cooperative and bedridden patients. This review provides an overview of the benefits and shortcomings of oral film technologies, oral cavity anatomy and physiology, drug transport and mucoadhesion mechanisms, as well as production methods and clinical trials.
MACROMOLECULAR RESEARCH
(2023)
Article
Polymer Science
Krubha Athirathinam, Selvasudha Nandakumar, Shanmugarathinam Alagarsamy, Ruckmani Kandasamy
Summary: This study evaluates the effectiveness of the Vi polysaccharide antigen of Salmonella Typhi in stabilizing the plague vaccine antigen, resulting in improved humoral immune response without an adjuvant. The use of taurine as a co-excipient and natural linker provides dynamic covalent bonding between the excipients, enhancing structural stability for 4 weeks at room temperature. The formulated antigen maintains its biological activity for up to 4 weeks, with significantly higher antibody response compared to the adjuvanted pure antigen stored at optimal temperature.
MACROMOLECULAR RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
P. Senthilkumar, S. Raja, R. Ramesh Babu, V. Kavinkumar, K. Jothivenkatachalam, G. Vasuki
Summary: In this study, undoped and SnO2:Cr-doped thin films were prepared by a homemade spray pyrolysis method and their characteristics were investigated. The results showed that Cr-doping can reduce the crystallite size and grain size of SnO2, and improve the photocatalytic performance.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Environmental Sciences
Nandakumar Selvasudha, Joseph PushpaSweety, Thekkila-Veedu Saranya, Kandasamy Ruckmani, Loganathan Gayathri
Summary: This study aimed to adapt a simple protein estimation method for detecting nisin and to formulate and evaluate site-specific nanoformulation for therapeutic applications. Among the three nanoformulations prepared and characterized, the one with gellan gum showed the best characteristics. Interaction and stability patterns were confirmed using FT-IR and DSC, and CD demonstrated the stability of nisin in an alkaline environment. The formulated gellan gum-nisin colloidal nanoparticles showed significant effectiveness against colon cancer cells and antimicrobial activity against Staphylococcus aureus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
A. Helen Sonia, R. Sambath Kumar, K. Ruckmani, M. Gover Antoniraj, V. M. Nallasamy, C. Kannan, M. Sudha
Summary: In this study, the plasma pharmacokinetics of abacavir sulphate were investigated after oral administration of different formulations. The results showed that both niosomal and proniosomal encapsulation of abacavir sulphate significantly increased its bioavailability and prolonged release characteristics. The half-life of the drug also increased in both formulations. It can be concluded that niosomal and proniosomal formulations are promising delivery systems for abacavir sulphate, with improved oral bioavailability and prolonged drug release profiles.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)