Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection

T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy

(2021) Gila Lustig et al.   PLoS Pathogens

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

(2020) Kerri G. Lal et al.   Nature Communications

Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation

(2019) Joanna Hellmuth et al.   JOURNAL OF INFECTIOUS DISEASES

Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection

(2019) Sodsai Tovanabutra et al.   Cells

Global HIV neurology

(2018) Kiran T. Thakur et al.   AIDS

Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV

(2018) Phillip Chan et al.   JOURNAL OF INFECTIOUS DISEASES

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

(2018) Donn J. Colby et al.   NATURE MEDICINE

Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection

(2018) A. R. Kallianpur et al.   MOLECULAR NEUROBIOLOGY

HIV-1 RNA Detected in the CNS after Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells

(2018) Sarah B Joseph et al.   CLINICAL INFECTIOUS DISEASES

Human Immunodeficiency Virus and the Nervous System

(2018) Emily Jane Sutherland et al.   NEUROLOGIC CLINICS

High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection

(2017) Cari F. Kessing et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques

(2017) Kenta Matsuda et al.   PLoS Pathogens

Combined single-cell quantitation of host and SIV genes and proteins ex vivo reveals host-pathogen interactions in individual cells

(2017) Diane L. Bolton et al.   PLoS Pathogens

Rates of non-confounded HIV-associated neurocognitive disorders in men initiating combination antiretroviral therapy during primary infection

(2016) Teresa H. Evering et al.   AIDS

Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology

(2016) Mark S. de Souza et al.   CLINICAL INFECTIOUS DISEASES

Erratum: HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4

(2015) Guan-Han Li et al.   AIDS

Increased Expression of CD169 on Blood Monocytes and Its Regulation by Virus and CD8 T Cells in Macaque Models of HIV Infection and AIDS

(2015) Woong-Ki Kim et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

(2015) Brian T. Nowlin et al.   AMERICAN JOURNAL OF PATHOLOGY

Comparative Analysis of Cell-Associated HIV DNA Levels in Cerebrospinal Fluid and Peripheral Blood by Droplet Digital PCR

(2015) Michelli Faria de Oliveira et al.   PLoS One

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

(2015) Christa Buckheit Sturdevant et al.   PLoS Pathogens

Cross-Clade Ultrasensitive PCR-Based Assays To Measure HIV Persistence in Large-Cohort Studies

(2014) C. Vandergeeten et al.   JOURNAL OF VIROLOGY

CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells

(2014) Leslie R. Cockerham et al.   PLoS One

Highly multiplexed quantitation of gene expression on single cells

(2013) Maria H. Dominguez et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases

(2013) M. C. Kowarik et al.   JOURNAL OF NEUROLOGY

Cellular Composition of Cerebrospinal Fluid in HIV-1 Infected and Uninfected Subjects

(2013) Emily L. Ho et al.   PLoS One

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)–Expressing CD4+ T cells

(2012) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy

(2011) Tae-Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals

(2011) Scott L. Letendre et al.   JOURNAL OF NEUROVIROLOGY

Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage

(2009) Woong-Ki Kim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection

(2009) G. Schnell et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Coordinated Regulation of SIV Replication and Immune Responses in the CNS

(2009) Kenneth W. Witwer et al.   PLoS One