Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 93, Issue -, Pages 695-702Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.09.040
Keywords
Ulvan; Green seaweed; Ulva lactuca; Cytotoxic activity
Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2013.43]
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The structure of an ulvan obtained by water extraction from green seaweed Ulva lactuca was elucidated by using IR, NMR, SEC-MALL and ESIMS methods. The ulvan was also evaluated for its cytotoxic effects on three human cancer cell lines. The results showed that the ulvan was composed of rhamnose, galactose, xylose, manose, glucose (with a mole ratio of Rha: Gal: Xyl: Man: Glu equal to 1: 0.03: 0.07: 0.01: 0.06), uronic acid (21.5%) and sulfate content (18.9%) with a molecular weight of 347000. This ulvan mainly consists of disaccharide [-> 4)-beta-n-GlcA-(1 -> 4)-alpha-L-Rha3S-(1 ->] and other minor disaccharide beta-GlcA-(1 -> 2)-alpha-Xyl and beta-GlcA-(->-2)-alpha-Rha. The ulvan showed a significant cytotoxic activity against hepatocellular carcinoma (IC50 29.67 +/- 2.87 g/ml), human breast cancer (IC50 25.09 +/- 1.36 mu g/ml), and cervical cancer (IC50 36.33 +/- 3.84 mu g/ml). (C) 2016 Elsevier B.V. All rights reserved.
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