Article
Public, Environmental & Occupational Health
Yeon-Mi Hwang, Samantha Piekos, Tanya Sorensen, Leroy Hood, Jennifer Hadlock
Summary: This study aimed to investigate the prophylactic anticoagulant use among hospitalized pregnant people with COVID-19 and evaluate its impact on coagulopathy, bleeding, COVID-19-related complications, and maternal-fetal health outcomes. The study found that most hospitalized pregnant patients with COVID-19 did not receive prophylactic anticoagulants as recommended by guidelines, and patients who received treatment were more likely to have severe COVID-19 illness. The study's limitation is the inability to assess the efficacy of prophylactic anticoagulant treatment.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Multidisciplinary Sciences
Andrea Lombardi, Silvia Duiella, Letizia Li Piani, Agnese Comelli, Ferruccio Ceriotti, Massimo Oggioni, Antonio Muscatello, Alessandra Bandera, Andrea Gori, Enrico Ferrazzi
Summary: COVID-19 affects obstetric patients, and inflammatory biomarkers and hemocytometry values can help predict disease severity. Patients with low lymphocyte values upon admission are more likely to require oxygen supplementation.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Obstetrics & Gynecology
Rahul K. Gajbhiye, Niraj N. Mahajan, Neha Kamath, Shubhada Bahirat, Gauri Patokar, Aishwarya V. Bhurke, Deepak N. Modi, Smita D. Mahale
Summary: In countries with a high burden of TB, pregnant women with symptomatic COVID-19 should be tested for TB. The infrastructure of the TB Program can be utilized for the control of COVID-19, and vice versa. Sharing resources and infrastructure can improve the control of both diseases.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Immunology
Cristiane de Freitas Paganoti, Rafaela Alkmin da Costa, Aris T. Papageorghiou, Fabricio da Silva Costa, Silvana Maria Quintana, Luciana Graziela de Godoi, Nataly Adriana Jimenez Monroy, Agatha Sacramento Rodrigues, Rossana Pulcineli Vieira Francisco
Summary: This study found that COVID-19 vaccination plays an important role in reducing the severity of COVID-19 infection among hospitalized pregnant and postpartum women, reducing the risk of intensive care unit admission, intubation, and death.
Article
Anesthesiology
Hawa Keita, Arthur James, Lionel Bouvet, Emilie Herrmann, Agnes Le Gouez, Jean-Xavier Mazoit, Frederic-Jean Mercier, Dan Benhamou
Summary: A retrospective multicentre cohort study conducted in France on pregnant women with COVID-19 showed significant maternal morbidity, high ICU admission rates, and utilization of invasive or non-invasive ventilation. The study revealed correlations between COVID-19 severity, gestational age, and factors associated with postpartum ventilation.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marcela de Andrade Pereira Silva, Helena Fiats Ribeiro, Rosana Rosseto de Oliveira, Fernando Castilho Pelloso, Constanza Pujals, Raissa Bocchi Pedroso, Maria Dalva de Barros Carvalho, Sandra Marisa Pelloso
Summary: This study analyzed the characteristics associated with Covid-19 vaccination in pregnant and postpartum women with Severe Acute Respiratory Syndrome in Brazil, and investigated the possible association between vaccination and the clinical course and outcome of the disease. The results identified demographic, ethnic-racial, and clinical factors associated with vaccination status in this population.
Article
Public, Environmental & Occupational Health
Aduragbemi Banke-Thomas, Cephas Ke-On Avoka, Uchenna Gwacham-Anisiobi, Olufemi Omololu, Mobolanle Balogun, Kikelomo Wright, Tolulope Temitayo Fasesin, Adedotun Olusi, Bosede Bukola Afolabi, Charles Ameh
Summary: This study assessed the maternal mortality rate in pregnant women with obstetrical emergencies in Lagos State, Nigeria, based on distance and travel time. The study found that distance and travel time had different influences on maternal mortality, with distances of 10-15 km and travel times of >= 120 min significantly associated with maternal death.
Review
Immunology
Marcelo Borges Cavalcante, Candice Torres de Melo Bezerra Cavalcante, Manoel Sarno, Ricardo Barini, Joanne Kwak-Kim
Summary: The COVID-19 pandemic has rapidly spread worldwide, affecting young adults of reproductive age the most. Pregnant women with COVID-19 may have increased risks of preterm birth, intrauterine growth restriction, and adverse developmental outcomes for their offspring. It is recommended to monitor the structural and systemic health of offspring exposed to SARS-CoV-2 in utero.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Manon Vouga, Guillaume Favre, Leo Pomar, Laura Forcen Acebal, Alejandra Abascal-Saiz, Maria Rosa Vila Hernandez, Najeh Hcini, Veronique Lambert, Gabriel Carles, Joanna Sichitiu, Laurent Salomon, Julien Stirnemann, Yves Ville, Begona Martinez de Tejada, Anna Gonce, Karen Castillo, Eduard Gratacos Solsona, Lucas Trigo, Brian Cleary, Michael Geary, Helena Bartels, Fergal Malone, Mary Higgins, Niamh Keating, Susan Knowles, Christophe Poncelet, Fernanda Surita, Carolina Borrelli, Adriana Gomes Luz, Javiera Fuenzalida, Jorge Carvajal, Manuel Guerra Canales, Olivia Hernandez, Olga Grechukhina, Albert Ko, Uma Reddy, Rita Figueiredo, Marina Moucho, PedroViana Pinto, Carmen De Luca, Marco De Santis, Diogo Ayres de Campos, Ines Martins, Charles Garabedian, Damien Subtil, Betania Bohrer, Maria Lucia Da Rocha Oppermann, Maria Celeste OsorioWender, Maria Teresa Vieira Sanseverino, Camila Giugliani, Luciana Friedrich, Mariana Horn Scherer, Nicolas Mottet, Guillaume Ducarme, Helene Pelerin, Chloe Moreau, Benedicte Breton, Thibaud Quibel, Patrick Rozenberg, Eric Giannoni, Cristina Granado, Cecile Monod, Doris Mueller, Irene Hoesli, Dirk Bassler, Sandra Heldstab, Nicole Ochsenbein Kolble, Loic Sentilhes, Melissa Charvet, Jan Deprest, Jute Richter, Lennart Van der Veeken, Beatrice Eggel-Hort, Gaetan Plantefeve, Mohamed Derouich, Albaro Jose Nieto Calvache, Kurt Hecher, Eran Hadar, Karina Krajden Haratz, Uri Amikam, Gustavo Malinger, Ron Maymon, Yariv Yogev, Leonhard Schafer, Arnaud Toussaint, Marie-Claude Rossier, RenatoAugusto Moreira De Sa, Claudia Grawe, Karoline Aebi-Popp, Luigi Raio, Daniel Surbek, Paul Bockenhof, Brigitte Strizek, Martin Kaufmann, Andrea Bloch, Michel Boulvain, Silke Johann, SandraAndrea Heldstab, MonyaTodesco Bernasconi, Gaston Grant, Anis Feki, Anne-Claude Muller Brochut, Marylene Giral, Lucie Sedille, Andrea Papadia, Romina Capoccia Brugger, Brigitte Weber, Tina Fischer, Christian Kahlert, Karin Nielsen Saines, Mary Cambou, Panagiotis Kanellos, Xiang Chen, Mingzhu Yin, Annina Haessig, Sandrine Ackermann, David Baud, Alice Panchaud
Summary: Pregnant women with severe COVID-19 are at higher risk of complications, with factors like pulmonary comorbidities, hypertensive disorders, and diabetes being identified as risk factors. Severe maternal outcomes may lead to caesarean section, preterm delivery, and newborns requiring admission to the neonatal intensive care unit.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Dana Gabrieli, Adva Cahen-Peretz, Tzvika Shimonovitz, Keren Marks-Garber, Hagai Amsalem, Yosef Kalish, Yuval Lavy, Asnat Walfisch
Summary: The study reveals that the incidence of pregnancy-related thromboembolic events in 2020 was 0.16% of all deliveries, significantly higher than in 2018 and 2019 (0.06% and 0.1% respectively). Higher rates of VTE events were found during post-lockdown periods in 2020 compared to the corresponding time periods in 2019 and 2018.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Medicine, Research & Experimental
Taraneh Arbabzadeh, Maryam Masoumi Shahrbabak, Parichehr Pooransari, Mahdi Khatuni, Masoumeh Mirzamoradi, Soraya Saleh Gargari, Zahra Naeiji, Nayereh Rahmati, Samaneh Omidi, Faridadin Ebrahimi Meimand
Summary: This retrospective cohort study aimed to investigate the clinical outcomes of pregnant women with moderate to severe COVID-19 following remdesivir administration. The study found that compared to pregnant women who did not receive remdesivir, those who received treatment had a shorter hospital stay, lower oxygen requirements, and a lower risk of developing preeclampsia. These findings provide initial evidence for the efficacy of remdesivir in pregnant women.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Ruiling Xu, Tara Alicia Pauley, Hannah Missfelder-Lobos, Richard John Haddon, Ravindra Kumar Gupta, Hsu Phern Chong
Summary: Rapid isothermal nucleic acid testing for COVID-19 in pregnant women attending maternity units was found to be acceptable with low turnaround time. The study showed a low rate of asymptomatic carriage in pregnant women, which was not correlated to community prevalence rates.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Public, Environmental & Occupational Health
Lu Xia, Peierdun Mijiti, Xu-Hui Liu, Zhi-Dong Hu, Xiao-Yong Fan, Shui-Hua Lu
Summary: This study aimed to compare maternal and perinatal outcomes in active TB cases after in vitro fertilization (IVF) treatment versus normal pregnancy. The results showed that pregnant women who received IVF treatment had worse maternal and perinatal outcomes compared to those who had a normal pregnancy, including a higher risk of maternal criticality, miliary TB, TB meningitis, and perinatal mortality.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Hongguang Chen, Yusong Zou, Hui Shi, Hongyan Ma, Wenyang Huang, Shuzhen Wang, Junli Lu
Summary: This study found that during the COVID-19 pandemic, pregnant women had a higher prevalence of psychological symptoms, which were associated with psychological resilience and attitudes towards the pandemic. The response of pregnant women to COVID-19 indirectly influenced their psychological symptoms through the mediating effect of maternal concerns.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Susan Niessink-Beckers, Corine J. Verhoeven, Marleen J. Nahuis, Lisanne A. Horvat-Gitsels, Janneke T. Gitsels-van der Wal
Summary: Maternal characteristics such as maternal age, body weight, preconception period, education level, deprivation, psychological problems, and consultations with an obstetrician are associated with women's referral from midwife-led to obstetrician-led care. These associations differ by parity and partum period.
Article
Genetics & Heredity
Celine Bruno, Abderrahmane Bourredjem, Fatima Barry, Jean Frappier, Aurelie Martinaud, Bruno Chamoy, Isabelle Hance, Perrine Ginod, Mathilde Cavalieri, Celine Amblot, Christine Binquet, Julie Barberet, Patricia Fauque
Summary: This study examined the effects of male and female factors on embryo development using two original designs. The results showed significant similarities related to female components, but lower similarities related to male factors. Furthermore, while no specific female factors were identified, oligozoospermia was associated with longer timings in the TL-DO design.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Biology
Hala Al Adhami, Anais Flore Bardet, Michael Dumas, Elouan Cleroux, Sylvain Guibert, Patricia Fauque, Herve Acloque, Michael Weber
Summary: This study investigates the distribution and function of DNA methylation in different vertebrate species, revealing both conservation and divergence in methylation patterns and functions. The study shows that the chicken genome has lower levels of methylation compared to other species and other species exhibit a higher frequency of CpG-rich DNA methylation compared to mice. The study also demonstrates the conservation of DNA methylation in silencing germline genes and endogenous retroviruses in vertebrates.
Review
Obstetrics & Gynecology
Julie Barberet, Bastien Ducreux, Magali Guilleman, Emmanuel Simon, Celine Bruno, Patricia Fauque
Summary: ART procedures might influence DNA methylation in fetus and placenta, potentially leading to increased risks of adverse outcomes associated with ART. Despite the growing body of literature on this topic, the conclusions from existing studies remain inconsistent, and the safety of ART at the epigenetic level is still uncertain.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Developmental Biology
Jean Frappier, Aurelie Martinaud, Julie Barberet, Celine Bruno, Magali Guilleman, Celine Amblot, Adrien Guilloteau, Patricia Fauque
Summary: This study assessed the impact of paternal smoking on embryo development in couples undergoing IVF and found that tobacco smoking did not have a major impact on clinical outcomes, although some differences were observed in the timing of embryonic events.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Obstetrics & Gynecology
Marie-Josee Gervoise-Boyer, Patricia Fauque, Jacques De Mouzon, Aviva Devaux, Sylvie Epelboin, Rachel Levy, Morgane Valentin, Geraldine Viot, Justine Bonomini, Marianne Bergere, Philippe Jonveaux, Fabienne Pessione
Summary: This study investigated the risk factors for prematurity other than intrauterine growth restriction in singletons after IVF. The results showed that endometriosis and vanishing twin increased the risk of prematurity after fresh embryo transfer, while polycystic ovaries or more than 20 oocytes retrieved also increased the risk of preterm birth.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Nathalie Sermondade, Laetitia Hesters, Jacques De Mouzon, Aviva Devaux, Sylvie Epelboin, Patricia Fauque, Marie-Jose Gervoise-Boyer, Julie Labrosse, Geraldine Viot, Marianne Berg, Claire Devienne, Philippe Jonveaux, Rachel Levy, Fabienne Pessione
Summary: Research question: This retrospective nationwide cohort study aimed to investigate the role of maternal context and medically assisted reproduction (MAR) techniques in the risk of fetal growth disorders. Design: Data from the French National Health System database were used from 2013 to 2017. Fetal growth disorders were categorized into four groups based on pregnancy origin: fresh embryo transfer, frozen embryo transfer (FET), intrauterine insemination (IUI), and natural conceptions. Results: The analysis showed that compared to natural conceptions, the risk of small for gestational age (SGA) was higher for births following fresh embryo transfer and IUI.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Reproductive Biology
Julie Barberet, Bastien Ducreux, Celine Bruno, Magali Guilleman, Raymond Simonot, Nicolas Lieury, Adrien Guilloteau, Deborah Bourc'his, Patricia Fauque
Summary: This study evaluated the efficiency of a semi-automated technique of oocyte vitrification and compared it with a manual method. The results showed comparable outcomes in terms of survival rate, morphometric assessment, and resistance to empty micro-injection between the two techniques. The transcriptomic consequences of the two methods also had limited differences, suggesting that the influence of vitrification technique itself may not be significant.
JOURNAL OF OVARIAN RESEARCH
(2022)
Editorial Material
Medicine, General & Internal
Bastien Ducreux, Patricia Fauque
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Sylvie Epelboin, Julie Labrosse, Jacques De Mouzon, Aviva Devaux, Marie-Jose Gervoise-Boyer, Laetitia Hesters, Philippe Jonveaux, Rachel Levy, Nathalie Sermondade, Patricia Fauque, Fabienne Pessione
Summary: This nationwide cohort study in France found that ovulatory cycle frozen embryo transfer (OC-FET) can reduce the risk of gestational hypertension and other vascular disorders in pregnant women compared to artificial cycle frozen embryo transfer (AC-FET) and fresh embryo transfer (fresh-ET). This suggests that OC-FET can serve as a protective factor for preventing maternal vascular pathologies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Bastien Ducreux, Catherine Patrat, Jacquetta Trasler, Patricia Fauque
Summary: This article focuses on the transcriptomic changes in human oocytes caused by specific interventions in ART and intrinsic factors such as age, reproductive health issues, and lifestyle. The results show that ART success is influenced by external factors, maternal aging, lifestyle factors, and infertility related to endometriosis or polycystic ovary syndrome. Different ART techniques also have an impact on oocyte transcriptomes. The dysregulation of epigenetic regulators may be a common mechanism linked to adverse oocyte environments.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Cell Biology
Bastien Ducreux, Julie Barberet, Magali Guilleman, Raquel Perez-Palacios, Aurelie Teissandier, Deborah Bourc'his, Patricia Fauque
Summary: The choice of embryo culture medium in assisted reproductive technologies is crucial for successful pregnancy rates and the health of future children. This study investigated the impact of different commercially available culture media on gene expression in human pre-implantation embryos. The findings revealed medium-specific differences in gene expression changes, but these differences were reduced at the blastocyst stage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Romualdo Sciorio, Claudio Manna, Patricia Fauque, Paolo Rinaudo
Summary: Since the birth of Louise Brown in 1978, over nine million children have been conceived using assisted reproductive technologies (ARTs). The potential epigenetic consequences of gametes and embryo manipulation during the preimplantation period have raised concerns. This review examines the evidence on oocytes and embryo cryopreservation and their potential impact on epigenetic regulation. Overall, the stress induced by vitrification procedures may lead to epigenetic and transcriptomic changes in oocytes and embryos, but it is unclear whether these changes will affect the health of future offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
L. Bujan, N. Nouri, A. Papaxanthos-Roche, B. Ducrocq, F. Brugnon, C. Ravel, N. Rives, M. Teletin, V Drouineaud, B. Delepine, I Berthaut, C. Metzler-Guillemain, A. Devaux, C. Frapsauce, E. Thibault, O. Blagosklonov, M. A. Clarotti, C. Diligent, V Loup Cabaniols, P. Fauque, M. Benchaib, F. Eustache, M. Daudin
Summary: There are moderate differences between non-parent and parent candidates in terms of motivations for gamete donation and personality characteristics.
HUMAN REPRODUCTION OPEN
(2022)
Article
Obstetrics & Gynecology
Julie Barberet, Christine Binquet, Magali Guilleman, Gaelle Romain, Celine Bruno, Aurelie Martinaud, Perrine Ginod, Mathilde Cavalieri, Celine Amblot, Cecile Choux, Patricia Fauque
Summary: The study found differences in DNA methylation levels and gene expression in the placenta and cord blood between natural conception and after IUI, indicating that infertility itself may contribute to potential epigenetic risks for children.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)