Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 81, Issue -, Pages 148-150Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2016.11.005
Keywords
CD98; Cancer; Integrins; Signalling; Amino acid transport
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Funding
- National Institute of Health Research
- National Institute for Health Research [ACF-2012-17-007] Funding Source: researchfish
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CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics. (C) 2016 Elsevier Ltd. All rights reserved.
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