Potential Value of Cerebrospinal Fluid Progranulin in the Identification of Postoperative Delirium in Geriatrics Patients Undergoing Knee Replacement: The Perioperative Neurocognitive Disorder and Biomarker LifestylE Study

Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice

(2020) Tuancheng Feng et al.   EMBO REPORTS

Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain

(2020) D. Monteiro-Fernandes et al.   NEUROSCIENCE

Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

(2020) Zhangxin Guan et al.   Frontiers in Cellular Neuroscience

Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans

(2020) Sabrina Simoes et al.   Science Translational Medicine

Elevated levels of extracellular vesicles in progranulin‐deficient mice and FTD‐ GRN Patients

(2020) Andrew E. Arrant et al.   Annals of Clinical and Translational Neurology

The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

(2019) Seyed A. Safavynia et al.   Frontiers in Psychiatry

Dementia and CSF‐Biomarkers for Alzheimer's Disease Predict Mortality after Acute Hip Fracture

(2019) Robert Dutkiewicz et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction

(2019) Qingyuan Fan et al.   JOURNAL OF NEUROSCIENCE

CSF Beta-amyloid 1–42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study

(2018) Emma L. Cunningham et al.   ANNALS OF SURGERY

Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice

(2018) Masato Hosokawa et al.   EXPERIMENTAL ANIMALS

Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration

(2018) Joery Goossens et al.   Alzheimers Research & Therapy

The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats

(2018) Ying Zhang et al.   Biomed Research International

Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice

(2018) Chunxia Huang et al.   NEUROPHARMACOLOGY

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

(2018) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Ratio of β-amyloid protein (Aβ) and Tau predicts the postoperative cognitive dysfunction on patients undergoing total hip/knee replacement surgery

(2017) Zhipeng Wu et al.   Experimental and Therapeutic Medicine

Progranulin Reduction Is Associated With Increased Tau Phosphorylation in P301L Tau Transgenic Mice

(2015) Masato Hosokawa et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein

(2014) Xi-ming Li et al.   Journal of Zhejiang University-SCIENCE B

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

(2014) S Sakura Minami et al.   NATURE MEDICINE

Using the Chinese version of Memorial Delirium Assessment Scale to describe postoperative delirium after hip surgery

(2014) Zhongyong Shi et al.   Frontiers in Aging Neuroscience

Preoperative cerebrospinal fluidβ-Amyloid/Tau ratio and postoperative delirium

(2014) Zhongcong Xie et al.   Annals of Clinical and Translational Neurology

Does Preoperative Risk for Delirium Moderate the Effects of Postoperative Pain and Opiate Use on Postoperative Delirium?

(2013) Jacqueline M. Leung et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

(2012) Lauren Herl Martens et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)

(2012) Hyeon-Sook Suh et al.   PLoS One

Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration

(2010) Thomas Philips et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Long-term Consequences of Postoperative Cognitive Dysfunction

(2009) Jacob Steinmetz et al.   ANESTHESIOLOGY

Plasma Amyloid β42 and Amyloid β40 Levels Are Associated With Early Cognitive Dysfunction After Cardiac Surgery

(2009) Lisbeth A. Evered et al.   ANNALS OF THORACIC SURGERY

Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia

(2009) Emmanuel Planel et al.   FASEB JOURNAL

Clinical utility and validation of two instruments (the Confusion Assessment Method Algorithm and the Chinese version of Nursing Delirium Screening Scale) to detect delirium in geriatric inpatients

(2008) Jess lam-ming Leung et al.   GENERAL HOSPITAL PSYCHIATRY