Article
Biology
Anastasiya Zaytseva, Evelina Bouckova, McKennon J. Wiles, Madison H. Wustrau, Isabella G. Schmidt, Hadassah Mendez-Vazquez, Latika Khatri, Seonil Kim
Summary: Ketamine enhances neuronal activity and synaptic strength by reducing calcineurin activity, leading to rapid antidepressant effects.
Article
Neurosciences
Ulyana Lalo, Yuriy Pankratov
Summary: Astroglia are important for brain plasticity and can release gliotransmitters to regulate synaptic strength. Research has shown that mGluR receptors in astrocytes can activate ATP release and cause synaptic depression through P2X receptors.
Review
Neurosciences
Jose Afonso Correa da Silva, Nadja Schroeder
Summary: It is believed that neurological diseases caused by degenerative conditions may have abnormal influx of Ca2+ through glutamate receptors. In addition to the NMDAR, AMPARs can also mediate neurotoxic Ca2+ influx, especially when the GluA2 subunit is absent or disrupted. The increase of Ca2+-permeable AMPA receptors (CP-AMPARs) is associated with behavioral changes and various neurodegenerative, neuroinflammatory, and neurotoxic conditions, suggesting a potential role in the emergence and evolution of central nervous system (CNS) pathological conditions. This article summarizes and discusses studies on changes in the composition of AMPARs and their effects, aiming to understand the therapeutic potential of CP-AMPAR in neurological diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Olga Kopach, Yulia Dobropolska, Pavel Belan, Nana Voitenko
Summary: The dorsal horn (DH) neurons of the spinal cord play a critical role in processing nociceptive input in the central nervous system. The hyperexcitability of DH neurons has been linked to Ca2+-permeable AMPA receptors (AMPARs) and contributes to nociceptive hypersensitivity. Inflammatory pain conditions result in changes in action potential (AP) parameters in DH neurons, and selective inhibition of Ca2+-permeable AMPARs can alleviate nociceptive hypersensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sergei G. Gaidin, Sergei A. Maiorov, Denis P. Laryushkin, Valery P. Zinchenko, Artem M. Kosenkov
Summary: Calcium-permeable AMPA receptors (CP-AMPARs) play a pivotal role in brain functioning, but their functions and role in network activity modulation remain unclear. This study developed a method to evaluate CP-AMPARs and studied their properties.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Amit Walia, Choongheon Lee, Jared Hartsock, Shawn S. Goodman, Roland Dolle, Alec N. Salt, Jeffery T. Lichtenhan, Mark A. Rutherford
Summary: The cochlear afferent synapses may contain GluA2-lacking CP-AMPARs, which can be acutely antagonized with systemic dosing to protect from glutamate excitotoxicity while transmission at GluA2-containing AMPARs persists to mediate hearing during the protection.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Jennifer L. Sanderson, Iain Stott, Andrew J. Young, Emma I. K. Vitikainen, Sarah J. Hodge, Michael A. Cant
Article
Behavioral Sciences
Hazel J. Nichols, Michael A. Cant, Jennifer L. Sanderson
BEHAVIORAL ECOLOGY
(2015)
Article
Behavioral Sciences
Harry H. Marshall, Jennifer L. Sanderson, Francis Mwanghuya, Robert Businge, Solomon Kyabulima, Michelle C. Hares, Emma Inzani, Gladys Kalema-Zikusoka, Kenneth Mwesige, Faye J. Thompson, Emma I. K. Vitikainen, Michael A. Cant
BEHAVIORAL ECOLOGY
(2016)
Article
Neurosciences
Jennifer L. Sanderson, Jessica A. Gorski, Mark L. Dell'Acqua
Article
Biology
Faye J. Thompson, Harry H. Marshall, Jennifer L. Sanderson, Emma I. K. Vitikainen, Hazel J. Nichols, Jason S. Gilchrist, Andrew J. Young, Sarah J. Hodge, Michael A. Cant
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2016)
Article
Multidisciplinary Sciences
Emma L. Inzani, Harry H. Marshall, Jennifer L. Sanderson, Hazel J. Nichols, Faye J. Thompson, Gladys Kalema-Zikusoka, Sarah J. Hodge, Michael A. Cant, Emma I. K. Vitikainen
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Faye J. Thompson, Michael A. Cant, Harry H. Marshall, Emma I. K. Vitikainen, Jennifer L. Sanderson, Hazel J. Nichols, Jason S. Gilchrist, Matthew B. V. Bell, Andrew J. Young, Sarah J. Hodge, Rufus A. Johnstone
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Ecology
Harry H. Marshall, Emma I. K. Vitikainen, Francis Mwanguhya, Robert Businge, Solomon Kyabulima, Michelle C. Hares, Emma Inzani, Gladys Kalema-Zikusoka, Kenneth Mwesige, Hazel J. Nichols, Jennifer L. Sanderson, Faye J. Thompson, Michael A. Cant
ECOLOGY AND EVOLUTION
(2017)
Article
Neurosciences
Jennifer L. Sanderson, John D. Scott, Mark L. Dell'Acqua
JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Harry H. Marshall, David J. Griffiths, Francis Mwanguhya, Robert Businge, Amber G. F. Griffiths, Solomon Kyabulima, Kenneth Mwesige, Jennifer L. Sanderson, Faye J. Thompson, Emma I. K. Vitikainen, Michael A. Cant
Article
Cell Biology
Dipen Rajgor, Alicia M. Purkey, Jennifer L. Sanderson, Theresa M. Welle, Joshua D. Garcia, Mark L. Dell'Acqua, Katharine R. Smith
Article
Behavioral Sciences
Monil Khera, Kevin Arbuckle, Joseph Hoffman, Jennifer L. Sanderson, Michael A. Cant, Hazel J. Nichols
Summary: Many species avoid inbreeding by recognizing familiar kin, but this rule does not apply to banded mongooses, which have communal breeding and caregiving systems that make it difficult to recognize kin based on familiarity. Despite frequent inbreeding, the use of alternative pre- or post-copulatory inbreeding avoidance mechanisms keeps inbreeding lower than expected if mates were randomly chosen.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2021)
Article
Ecology
Hazel J. Nichols, Kevin Arbuckle, Jennifer L. Sanderson, Emma I. K. Vitikainen, Harry H. Marshall, Faye J. Thompson, Michael A. Cant, David A. Wells
Summary: The study found that cooperative personalities are not always highly heritable in wild environments, and that the basis of behavioral traits can vary within a species, influenced by factors such as sex. It also showed that the pathways of inheritance through genetic or cultural factors may be difficult to distinguish in natural systems.
Article
Neurosciences
Jennifer L. Sanderson, Ronald K. Freund, Anna M. Castano, Timothy A. Benke, Mark L. Dell 'Acqua
Summary: This study provides insights into how alterations in CaV1.2 channel function disrupt basal transmission and plasticity, which are relevant for neurobehavioral alterations in Autism Spectrum Disorders (ASD). Individuals with Timothy Syndrome (TS) and TS2-neo mice exhibit social deficits and cognitive impairments similar to ASD. The synaptic function in the hippocampal CA1 region of TS2-neo mice shows slightly increased excitatory transmission and strongly decreased inhibitory transmission, potentially related to the synaptic dysfunction caused by CaV1.2 channel mutations.