Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

(2020) Lien Verboom et al.   Cell Reports

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

(2020) Rune Busk Damgaard et al.   CELL DEATH AND DIFFERENTIATION

RIPK2 NODs to XIAP and IBD

(2020) Yusuf Topal et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling

(2018) Yu Zhao et al.   MOLECULAR CELL

DIALS: implementation and evaluation of a new integration package

(2018) Graeme Winter et al.   Acta Crystallographica Section D-Structural Biology

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

(2017) Ran Wei et al.   GENES & DEVELOPMENT

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

(2017) Matous Hrdinka et al.   MOLECULAR CELL

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling

(2016) Christoph H. Emmerich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular basis for specificity of the Met1-linked polyubiquitin signal

(2016) P. R. Elliott   BIOCHEMICAL SOCIETY TRANSACTIONS

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

(2016) Rune Busk Damgaard et al.   CELL

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

(2016) Sebastian A Wagner et al.   EMBO JOURNAL

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

(2016) Lisa Schlicher et al.   EMBO REPORTS

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

(2016) Matous Hrdinka et al.   Cell Reports

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

(2015) Qing Zhou et al.   NATURE GENETICS

Homology modeling of larger proteins guided by chemical shifts

(2015) Yang Shen et al.   NATURE METHODS

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity

(2015) Yusuke Sato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy

(2015) Si Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layers of DUB regulation

(2015) Danny D. Sahtoe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity

(2015) Yusuke Sato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

IKK regulates the deubiquitinase CYLD at the postsynaptic density

(2014) Soe Thein et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

(2014) Tsuyoshi Takiuchi et al.   GENES TO CELLS

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation

(2014) Sonja I. Gringhuis et al.   Nature Communications

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

(2013) Rune Busk Damgaard et al.   EMBO Molecular Medicine

BEST-TROSY experiments for time-efficient sequential resonance assignment of large disordered proteins

(2013) Zsofia Solyom et al.   JOURNAL OF BIOMOLECULAR NMR

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications

(2013) Jose L. Ortega Roldan et al.   PLoS One

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-dependent activity of the deubiquitinase DUBA

(2012) Oscar W Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Accelerated NMR Spectroscopy by Using Compressed Sensing

(2011) Krzysztof Kazimierczuk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface Chemistry and Interfacial Charge-Transfer Mechanisms in Photoinduced Oxygen Exchange at O2-TiO2 Interfaces

(2011) Juan Felipe Montoya et al.   CHEMPHYSCHEM

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Deubiquitinases in the regulation of NF-κB signaling

(2010) Edward W Harhaj et al.   CELL RESEARCH

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

(2009) Sara A Wickström et al.   EMBO JOURNAL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

(2009) Roland Hjerpe et al.   EMBO REPORTS

Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation

(2009) Jessica E. Hutti et al.   MOLECULAR CELL

The Tumor Suppressor CYLD Regulates Microtubule Dynamics and Plays a Role in Cell Migration

(2008) Jinmin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

(2008) David Komander et al.   MOLECULAR CELL

Consistent blind protein structure generation from NMR chemical shift data

(2008) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA