Article
Biochemistry & Molecular Biology
Minako Sakurai, Peter Weber, Gretchen Wolff, Annika Wieder, Julia Szendroedi, Stephan Herzig, Bilgen Ekim uestuenel
Summary: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and liver fibrosis are progressive liver diseases associated with metabolic syndrome. The elevated expression of TSC22D4 in patients with type 2 diabetes, NAFLD, and NASH suggests its involvement in the progression of these diseases. The study reveals that TSC22D4 contributes to the activation, proliferation, and migration of hepatic stellate cells (HSCs), implicating it as a key regulator in the development of liver fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Qiang Zhu, Hongxing Wang, Siyuan Chai, Liang Xu, Bingyi Lin, Wen Yi, Liming Wu
Summary: Programmed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) play a role in T cell-mediated immune response against tumors. The regulation of cell surface PD-L1 is not well understood, but it is shown in this study that lysosomal degradation of PD-L1 is regulated by O-linked N-acetylglucosamine (O-GlcNAc). Inhibition of O-GlcNAc activates T cell-mediated anti-tumor immunity and combining it with PD-L1 antibody enhances the immune response. A competitive peptide inhibitor of HGS glycosylation decreases PD-L1 expression and enhances T cell-mediated immunity against tumor cells. This study reveals a link between O-GlcNAc and tumor immune evasion, providing strategies for improving PD-L1-mediated immune checkpoint blockade therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Zhiman Li, Lijuan Zhao, Yunshi Xia, Jianbo Chen, Mei Hua, Yinshi Sun
Summary: The study demonstrates that Schisandrin B inhibits the activity of hepatic stellate cells induced by TGF-beta 1 by promoting apoptosis.
Article
Biochemistry & Molecular Biology
Chan Qiu, Yi Liu, Shengjie Huang, Bo Ning, Song He, Li Zhong
Summary: Our study demonstrated that Rab31 could promote hepatic stellate cells activation by accelerating TGF-beta Receptor II complex endocytosis, suggesting that interfering with Rab31 could be an effective strategy to inhibit hepatic fibrosis progression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chen Shuai, Guo-qing Xia, Fei Yuan, Sheng Wang, Xiong-wen Lv
Summary: CD39 plays a role in alcoholic liver disease by regulating HSC activation and fibrosis development, and its blockade can prevent these processes. The findings suggest that ATP-adenosine signaling is a novel therapeutic target for alcoholic liver disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Jie Mei, Yun Cai, Huiyu Wang, Rui Xu, Jiaofeng Zhou, Jiahui Lu, Xuejing Yang, Jiadong Pan, Chaoying Liu, Junying Xu, Yichao Zhu
Summary: This study aims to explore the expressions, prognostic values, and immunological correlations of Formins in cancer. DIAPH1 functioned as an oncogene in breast cancer and mediated epithelial-mesenchymal transformation (EMT) and PD-L1 expression. Moreover, DIAPH1 was overexpressed in most cancers and functioned as a novel pan-cancer immuno-marker, which could predict the response to anti-PD-1/PD-L1 immunotherapy.
CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Anand V. R. Kornepati, Jacob T. Boyd, Clare E. Murray, Julia Saifetiarova, Barbara de la Pena Avaios, Cody M. Rogers, Haiyan Bai, Alvaro S. Padron, Yiji Liao, Carlos Ontiveros, Robert S. Svatek, Robert Hromas, Rong Li, Yanfen Hu, Jose R. Conejo-Garcia, Ratna K. Vadlamudi, Weixing Zhao, Elose Dray, Patrick Sung, Tyler J. Curiel
Summary: BRCA1-mediated homologous recombination is regulated by the immune checkpoint molecule PD-L1, with genetic depletion of tumor PD-L1 affecting DNA repair mechanisms and sensitizing tumors to PARP inhibitors, highlighting a potential therapeutic vulnerability and response biomarker.
Article
Pharmacology & Pharmacy
Chenglong Liu, Feilong Zhou, Ziqin Yan, Lian Shen, Xichen Zhang, Fenglian He, Heng Wang, Xiaojie Lu, Ker Yu, Yujun Zhao, Di Zhu
Summary: The newly identified lead compound ZE132 targeting PD-1/PD-L1 interactions shows promising drug-like properties in vitro and in vivo, and has advantages over anti-PD-1 antibody in overcoming the barrier of TIME.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin Yan, Ji-Hua Shi, Jian-Feng Xue, Wen-Zhi Guo, Bin Li, Shui-Jun Zhang
Summary: The study revealed that blocking the PD-1/PD-L1 pathway can enhance small-for-size liver regeneration by inducing M1 macrophage polarization, while M2 macrophage polarization and upregulation of PD-L1 expression can lead to compromised liver regeneration.
Article
Biology
Alexander A. Strait, Rachel A. Woolaver, Spencer C. Hall, Christian D. Young, Sana D. Karam, Antonio Jimeno, Yan Lan, David Raben, Jing H. Wang, Xiao-Jing Wang
Summary: Strait et al. identified distinct immune microenvironment profiles of responders versus non-responders to combined TGF-beta/PD-L1 blockade in mouse models of SCC, highlighting the potential of targeted therapy and providing important insights into personalized immunotherapy for SCC.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ning Zhang, Fang Guo, Yuanyuan Song
Summary: This study found that HOXC8 plays a crucial role in liver fibrosis by activating the TGF-b1 signaling pathway, promoting hepatic stellate cell activation and fibrosis. Inhibition of HOXC8 may serve as a promoting therapeutic strategy for liver fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zuodong Ye, Yiding Xiong, Wang Peng, Wenjie Wei, Lihong Huang, Juliana Yue, Chunyuan Zhang, Ge Lin, Feng Huang, Liang Zhang, Songguo Zheng, Jianbo Yue
Summary: The aberrant regulation of PD-L1 in tumor cells is poorly understood. This study investigates the endosomal trafficking of plasma membrane PD-L1 in tumor cells and demonstrates that it is Rab5- and clathrin-dependent. Triazine compound 6J1 blocks this trafficking and promotes exosomal PD-L1 secretion by activating Rab27. This research provides new insights into the manipulation of PD-L1 endosomal trafficking.
Article
Medicine, Research & Experimental
Ghazaleh Khalili-Tanha, Hamid Fiuji, Masoumeh Gharib, Meysam Moghbeli, Nima Khalili-Tanha, Farzad Rahmani, Neda Shakour, Mina Maftooh, Seyed Mahdi Hassanian, Fereshteh Asgharzadeh, Soodabeh Shahidsales, Kazem Anvari, M. R. Mozafari, Gordon A. Ferns, Jyotsna Batra, Elisa Giovannetti, Majid Khazaei, Amir Avan
Summary: Immunosuppressive factors within the tumor microenvironment hinder the effectiveness of immunotherapeutic approaches in colorectal cancer (CRC), and targeting PD-L1 and TGF-ss pathways through M7824 and 5-FU shows potential therapeutic value. The co-targeting of PD-L1 and TGF-ss inhibits cell growth and migration, modulates key proteins involved in tumor growth and inflammatory response, providing a new therapeutic option in the treatment of CRC.
Article
Gastroenterology & Hepatology
Kuo Du, Seh Hoon Oh, Rajesh K. Dutta, Tianai Sun, Wen-Hsuan Yang, Jen-Tsan Chi, Anna Mae Diehl
Summary: Inhibiting xCT can reduce myofibroblastic activity and induce ferroptosis in hepatic stellate cells (HSCs). However, targeting xCT inhibition specifically to myofibroblastic HSCs is crucial to effectively exploit ferroptosis as an anti-fibrotic strategy.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Shiwei Wang, Lingling He, Fan Xiao, Meixin Gao, Herui Wei, Junru Yang, Yang Shu, Fuyang Zhang, Xiaohui Ye, Ping Li, Xiaohua Hao, Xingang Zhou, Hongshan Wei
Summary: The upregulation of GLT25D1 in hepatic stellate cells promotes the progression of liver fibrosis by affecting HSC activation and collagen stability.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)