NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

(2019) Gerta Hoxhaj et al.   SCIENCE

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

(2019) Jan Korbecki et al.   INFLAMMATION RESEARCH

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

(2019) Ilan Y. Benador et al.   Cell Metabolism

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

(2019) Rupali Ugrankar et al.   DEVELOPMENTAL CELL

Regulation of glucose and lipid metabolism in health and disease

(2019) Ligong Chen et al.   Science China-Life Sciences

Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

(2019) Maria J. Bueno et al.   Nature Communications

Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals

(2019) Takaoki Kasahara et al.   FASEB JOURNAL

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

(2019) Charles P. Najt et al.   MOLECULAR CELL

Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms

(2019) Xiao Yang et al.   PLoS Genetics

Who and how in the regulation of mitochondrial cristae shape and function

(2018) R. Quintana-Cabrera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice

(2018) Kezhong Zhang et al.   GASTROENTEROLOGY

Seipin regulates lipid homeostasis by ensuring calcium‐dependent mitochondrial metabolism

(2018) Long Ding et al.   EMBO JOURNAL

Structural basis for regulation of human acetyl-CoA carboxylase

(2018) Moritz Hunkeler et al.   NATURE

Mitochondria as central regulators of neural stem cell fate and cognitive function

(2018) Mireille Khacho et al.   NATURE REVIEWS NEUROSCIENCE

Glucose-6-phosphate dehydrogenase as a target for highly efficient fatty acid biosynthesis in microalgae by enhancing NADPH supply

(2017) Jiao Xue et al.   METABOLIC ENGINEERING

Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target

(2017) Douglas Buckley et al.   PHARMACOLOGY & THERAPEUTICS

Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition

(2017) Wei Fan et al.   PLoS Genetics

NAD+ Kinase as a Therapeutic Target in Cancer

(2016) P. M. Tedeschi et al.   CLINICAL CANCER RESEARCH

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

(2016) Ming-Da Wang et al.   HEPATOLOGY

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

(2016) Violeta I. Gallardo-Montejano et al.   Nature Communications

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase

(2015) Ren Zhang   JOURNAL OF CELLULAR PHYSIOLOGY

The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica

(2015) Thomas M. Wasylenko et al.   METABOLIC ENGINEERING

NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms

(2015) Nick R. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial β-Oxidation regulates Drosophila Energy Metabolism

(2015) Joachim G. Schulz et al.   Scientific Reports

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia

(2014) Sander M. Houten et al.   HUMAN MOLECULAR GENETICS

Methods for studying metabolism in Drosophila

(2014) Jason M. Tennessen et al.   METHODS

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Fatty Acid Synthase Inhibitors Induce Apoptosis in Non-Tumorigenic Melan-A Cells Associated with Inhibition of Mitochondrial Respiration

(2014) Franco A. Rossato et al.   PLoS One

CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway

(2014) Yuan Liu et al.   PLoS Genetics

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

High mitochondria content is associated with prostate cancer disease progression

(2013) Katharina Grupp et al.   Molecular Cancer

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization

(2012) J. Bi et al.   JOURNAL OF CELL SCIENCE

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

The phosphate makes a difference: cellular functions of NADP

(2010) Line Agledal et al.   REDOX REPORT

Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand: Figure 1.

(2009) Vishal M. Gohil et al.   JOURNAL OF CELL BIOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols