Loop extrusion promotes an alternate pathway for isotype switching

Fundamental roles of chromatin loop extrusion in antibody class switching

(2019) Xuefei Zhang et al.   NATURE

The Energetics and Physiological Impact of Cohesin Extrusion

(2018) Laura Vian et al.   CELL

Organizational principles of 3D genome architecture

(2018) M. Jordan Rowley et al.   NATURE REVIEWS GENETICS

53BP1 Contributes toIghLocus Chromatin Topology during Class Switch Recombination

(2017) Scott Feldman et al.   JOURNAL OF IMMUNOLOGY

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

(2017) Fabio Iannelli et al.   Nature Communications

The 3D Genome as Moderator of Chromosomal Communication

(2016) Job Dekker et al.   CELL

The cell cycle restricts activation-induced cytidine deaminase activity to early G1

(2016) Qiao Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

(2016) Yee Ling Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire

(2016) Lindsey Montefiori et al.   Cell Reports

Formation of Chromosomal Domains by Loop Extrusion

(2016) Geoffrey Fudenberg et al.   Cell Reports

Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA

(2015) Simin Zheng et al.   CELL

A CTCF Code for 3D Genome Architecture

(2015) Michael H. Nichols et al.   CELL

Constraints Contributed by Chromatin Looping Limit Recombination Targeting during Ig Class Switch Recombination

(2015) Scott Feldman et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Elongation Factor ENL Phosphorylated by ATM Recruits Polycomb and Switches Off Transcription for DSB Repair

(2015) Ayako Ui et al.   MOLECULAR CELL

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

(2015) Junchao Dong et al.   NATURE

The B-cell antigen receptor integrates adaptive and innate immune signals

(2015) Kevin L. Otipoby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New roles for DNA cytosine modification, eRNA, anchors, and superanchors in developing B cell progenitors

(2015) Christopher Benner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

(2015) Adrian L. Sanborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID

(2015) Quy Le et al.   PLoS Genetics

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination

(2014) L. Khair et al.   JOURNAL OF IMMUNOLOGY

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

(2014) Evangelos Pefanis et al.   NATURE

Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions

(2014) Ralph Stadhouders et al.   PLOS BIOLOGY

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny

(2013) S. Kumar et al.   GENES & DEVELOPMENT

The distinctive germinal center phase of IgE + B lymphocytes limits their contribution to the classical memory response

(2013) Jin-Shu He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Chromatin Profiling Reveals Novel Enhancers in Ig H and Ig L Chain Loci

(2013) A. V. Predeus et al.   JOURNAL OF IMMUNOLOGY

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

(2012) Tom Sexton et al.   CELL

Sequential class switching is required for the generation of high affinity IgE antibodies

(2012) Huizhong Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

IgE+ memory B cells and plasma cells generated through a germinal-center pathway

(2012) Oezcan Talay et al.   NATURE IMMUNOLOGY

Robust 4C-seq data analysis to screen for regulatory DNA interactions

(2012) Harmen J G van de Werken et al.   NATURE METHODS

AID targeting is dependent on RNA polymerase II pausing

(2012) Amy L. Kenter   SEMINARS IN IMMUNOLOGY

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

(2012) Egest J. Pone et al.   Nature Communications

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

Increased Targeting of Donor Switch Region and IgE in S 1-Deficient B Cells

(2010) S. Misaghi et al.   JOURNAL OF IMMUNOLOGY

Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions

(2010) T. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ikaros controls isotype selection during immunoglobulin class switch recombination

(2009) MacLean Sellars et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Housekeeping while brain's storming Validation of normalizing factors for gene expression studies in a murine model of traumatic brain injury

(2008) Hervé Rhinn et al.   BMC MOLECULAR BIOLOGY