Article
Pharmacology & Pharmacy
Yau-tuen Chan, Hor-yue Tan, Yuanjun Lu, Cheng Zhang, Chien-shan Cheng, Junyu Wu, Ning Wang, Yibin Feng
Summary: The tumor microenvironment affects the prognosis of pancreatic adenocarcinoma patients, and proper regulation can improve survival. Melatonin, an endogenous hormone, plays a role in inhibiting tumor growth by inducing infiltration and activation of tumor-associated neutrophils (TANs), leading to apoptosis of pancreatic cancer cells through cell-to-cell contact.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemistry & Molecular Biology
Khetam Sounbuli, Nadezhda Mironova, Ludmila Alekseeva
Summary: Neutrophils, the most abundant leukocytes in human blood, have been recognized as important players in the innate immune system and the first line of defense against invading pathogens. Recent studies have revealed their active involvement in the immune response during cancer development. They exhibit both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Furthermore, the existence of different subpopulations of neutrophils challenges the traditional concept of their homogeneity and opens new possibilities for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Sarah Jaboury, Kenny Wang, Kim Maree O'Sullivan, Joshua Daniel Ooi, Gwo Yaw Ho
Summary: Neutrophil Extracellular Traps (NETs) are a form of pro-inflammatory cell death characterized by the release of DNA webs containing bactericidal enzymes. NETosis plays a role in autoimmune diseases and cancer, causing tissue damage and promoting tumor growth. This mini-review summarizes the interaction between neutrophils, particularly NETosis, and cancer cells, highlighting potential targets for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Junjie Zhao, Jiaqi Jin
Summary: This review discusses recent investigations into NETs and their roles in tumor biology, as well as explores their potential as therapeutic targets in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Paulina Valadez-Cosmes, Sofia Raftopoulou, Zala Nikita Mihalic, Gunther Marsche, Julia Kargl
Summary: Myeloperoxidase is an important enzyme found in neutrophils that functions as a catalyzer of reactive oxidants to clear pathogens. It also has non-canonical functions and may play a role in inflammatory diseases and cancer development.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Oncology
Song Chen, Qingyu Zhang, Lisha Lu, Chunhui Xu, Jiajia Li, Jiali Zha, Fengxia Ma, Hongbo R. Luo, Alan Y. Hsu
Summary: Neutrophils play a crucial role in defense against bacteria and immune responses. However, their involvement in tumor development shows both pro-tumor and anti-tumor properties. They can promote tumor growth by facilitating interactions between tumor cells and surrounding cells, but they can also mediate anti-tumor functions by direct cytotoxicity or crosstalk with other immune cells.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Oncology
Lara Gibellini, Rebecca Borella, Elena Santacroce, Eugenia Serattini, Federica Boraldi, Daniela Quaglino, Beatrice Aramini, Sara De Biasi, Andrea Cossarizza
Summary: This review discusses the emerging concepts in the field of neutrophils in cancer, summarizing recent findings that highlight the role of both circulating neutrophils and tumor-associated neutrophils in tumor prognosis and resistance to immune checkpoint inhibitors. Neutrophils are the most abundant myeloid cells in the blood and significant components of the tumor microenvironment. However, their functional importance has been overlooked in the past due to the perception of them as a mono-dimensional population of terminally differentiated, short-lived cells. The use of cutting-edge single-cell technologies has revealed the phenotypic and functional heterogeneity of neutrophils, leading to a new understanding of their significance in cancer.
Article
Biochemistry & Molecular Biology
Sofia Raftopoulou, Paulina Valadez-Cosmes, Zala Nikita Mihalic, Rudolf Schicho, Julia Kargl
Summary: Neutrophils play crucial roles in cancer progression, being regulated by tumor microenvironment factors during their release, recruitment, and functional polarization processes. Moreover, neutrophils actively stimulate the tumor microenvironment through secreted factors that affect immune interactions and subsequent tumor progression. Understanding different neutrophil subpopulations or polarization states, as well as identifying tumor microenvironment-derived factors of neutrophil polarization, would allow us to fully harness the potential of neutrophils as complementary targets in anticancer precision therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Mara Zippoli, Anna Ruocco, Rubina Novelli, Francesca Rocchio, Martina Sara Miscione, Marcello Allegretti, Maria Candida Cesta, Pier Giorgio Amendola
Summary: Tumor drug resistance is a significant challenge in clinical oncology, and tumor-associated neutrophils play a crucial role in this process. Understanding how neutrophils regulate tumor progression and resistance is essential for developing new therapeutic approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haiying Que, Qianmei Fu, Tianxia Lan, Xiaohe Tian, Xiawei Wei
Summary: This review discusses the complex roles of neutrophils in the tumor microenvironment and highlights the progress in neutrophil-targeted therapies in ongoing clinical trials.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Colin Timaxian, Christoph F. A. Vogel, Charlotte Orcel, Diana Vetter, Camille Durochat, Clarisse Chinal, Phuong Nguyen, Marie-Laure Aknin, Francoise Mercier-Nome, Martin Davy, Isabelle Raymond-Letron, Thi-Nhu-Ngoc Van, Sarah D. Diermeier, Anastasia Godefroy, Magali Gary-Bobo, Franck Molina, Karl Balabanian, Gwendal Lazennec
Summary: Chemokines in the tumor microenvironment play a crucial role in controlling tumor progression. Knocking down Cxcr2 in PyMT animals led to increased primary tumor growth and lung metastasis, with an increase in TAN infiltration and decrease in TAM recruitment. Lack of Cxcr2 promotes pro-tumor effects in TANs through up-regulation of pro-tumor pathways.
Review
Biochemistry & Molecular Biology
Hikmet Akkiz
Summary: Hepatocellular carcinoma (HCC) is a prevalent cancer that ranks fourth in cancer-related deaths globally. The tumor microenvironment (TME) formed by HCC cells and various stromal and inflammatory cells plays a crucial role in tumor growth, metastasis, and drug resistance. Cancer-associated fibroblasts (CAFs) are an important component of the TME and their signaling can contribute to drug resistance. However, CAFs display heterogeneity and can also have antitumor properties. Understanding the crosstalk between CAFs, HCC cells, and other stromal cells is essential for the development of effective targeted therapies for HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Man Yan, Minying Zheng, Rui Niu, Xiaohui Yang, Shifeng Tian, Linlin Fan, Yuwei Li, Shiwu Zhang
Summary: This review article describes the potential mechanisms of tumor-associated neutrophils (TANs) in tumor metastasis and the promising future of cancer immunotherapy through targeting TANs with chemotherapeutic drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Sara Artigas-Jeronimo, Almudena Gonzalez-Garcia, Jose de la Fuente, Valeria Blanda, Mojtaba Shekarkar Azgomi, Margarita Villar, Leila Mohammadnezhad, Francesca Grippi, Alessandra Torina, Guido Sireci
Summary: This study conducted bioinformatics analysis to further characterize the interactions between Anaplasma phagocytophilum and its host. The results revealed the overrepresentation of proteins involved in the reactive oxygen species pathway and cell surface monocyte markers in infected human cells. This may induce cell death and the formation of neutrophil extracellular traps as defense mechanisms against invading microorganisms.
Review
Oncology
Sanjana Rajgopal, Kosuke Nakano, Leah M. Cook
Summary: Cancer is a complex and dynamic disease, and immune cells, especially neutrophils, play important roles in it. Immunotherapy has revolutionized cancer treatment, and neutrophils have the potential to become the next generation of immunotherapies. This article reviews current immunotherapy strategies, thoroughly discusses the roles of neutrophils in cancer, and explores novel neutrophil-targeted methods for treating cancer.
Article
Microbiology
George Tetz, Victor Tetz
Summary: In this in silico study, prion-like domains were identified in the spike protein of SARS-CoV-2 using the PLAAC algorithm. These domains were found to play important functional roles in viral adhesion and entry by interacting with the receptor-binding domain (RBD) and ACE2 region. The higher affinity of SARS-CoV-2 for ACE2 compared to SARS-CoV was attributed to the presence of prion-like domains. Additionally, substantial differences in the prion-like domain of the spike protein were observed across emerging variants including Omicron.
Article
Immunology
Ivan A. Molodtsov, Evgenii Kegeles, Alexander N. Mitin, Olga Mityaeva, Oksana E. Musatova, Anna E. Panova, Mikhail Pashenkov, Iuliia O. Peshkova, Almaqdad Alsalloum, Walaa Asaad, Anna S. Budikhina, Alexander S. Deryabin, Inna Dolzhikova, Ioanna N. Filimonova, Alexandra N. Gracheva, Oxana I. Ivanova, Anastasia Kizilova, Viktoria V. Komogorova, Anastasia Komova, Natalia Kompantseva, Ekaterina Kucheryavykh, Denis A. Lagutkin, Yakov A. Lomakin, Alexandra Maleeva, Elena Maryukhnich, Afraa Mohammad, Vladimir V. Murugin, Nina E. Murugina, Anna Navoikova, Margarita F. Nikonova, Leyla A. Ovchinnikova, Yana Panarina, Natalia Pinegina, Daria M. Potashnikova, Elizaveta Romanova, Aleena A. Saidova, Nawar Sakr, Anastasia G. Samoilova, Yana Serdyuk, Naina T. Shakirova, Nina Sharova, Saveliy A. Sheetikov, Anastasia F. Shemetova, Liudmila Shevkova, Alexander Shpektor, Anna Trufanova, Anna Tvorogova, Valeria M. Ukrainskaya, Anatoliy S. Vinokurov, Daria A. Vorobyeva, Ksenia Zornikova, Grigory A. Efimov, Musa R. Khaitov, Ilya A. Kofiadi, Alexey A. Komissarov, Denis Y. Logunov, Nelli B. Naigovzina, Yury P. Rubtsov, Irina A. Vasilyeva, Pavel Volchkov, Elena Vasilieva
Summary: In a prospective study involving 5340 individuals, the researchers found that both humoral and cellular responses to COVID-19 are closely related to the level of protection against infection. Individuals with both antibody and T-cell responses had the lowest incidence of COVID-19. Antibody response alone provided a significant level of protection, while T-cell response alone only offered intermediate protection.
CLINICAL INFECTIOUS DISEASES
(2022)
Letter
Hematology
Valeria Ukrainskaya, Olga Molostova, Larisa Shelikhova, Dmitriy Pershin, Elena Kulakovskaya, Dmitry Volkov, Arina Rakhteenko, Yakov Muzalevskii, Alexei Kazachenok, Varvara Brilliantova, Daria Osipova, Yury Rubtsov, Alexey Stepanov, Michael Maschan
Article
Immunology
Yakov A. A. Lomakin, Ivan V. V. Zvyagin, Leyla A. A. Ovchinnikova, Marsel R. R. Kabilov, Dmitriy B. B. Staroverov, Artem Mikelov, Alexey E. E. Tupikin, Maria Y. Y. Zakharova, Nadezda A. A. Bykova, Vera S. S. Mukhina, Alexander V. V. Favorov, Maria Ivanova, Taras Simaniv, Yury P. P. Rubtsov, Dmitriy M. M. Chudakov, Maria N. N. Zakharova, Sergey N. N. Illarioshkin, Alexey A. A. Belogurov Jr, Alexander G. G. Gabibov
Summary: This study reveals impaired development of B regulatory cells and lower levels of hypermutations in the B cell receptor (BCR) heavy chain in multiple sclerosis (MS) patients. These findings suggest the important role of B regulatory cells in the progression of MS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tatyana F. Kovalenko, Bhupender Yadav, Ksenia S. Anufrieva, Yury P. Rubtsov, Timofey S. Zatsepin, Evgenya Y. Shcherbinina, Ekaterina M. Solyus, Dmitry B. Staroverov, Tatyana D. Larionova, Yaroslav A. Latyshev, Michail I. Shakhparonov, Amit Kumar Pandey, Marat S. Pavlyukov
Summary: linc-RoR, a long non-coding RNA, plays an important role in glioblastoma. It is highly expressed in cells with increased EGFR expression. Knockdown of linc-RoR inhibits cell proliferation, increases sensitivity to DNA damage, and downregulates cancer stem cell markers. On the other hand, overexpression of linc-RoR promotes cell growth and increases the proportion of cancer stem cells. RNA sequencing analysis reveals that linc-RoR affects the expression of genes involved in mitotic regulation.
Article
Microbiology
G. Tetz, K. Kardava, M. Vecherkovskaya, A. Hahn, M. Tsifansky, A. Koumbourlis, V. Tetz
Summary: Antibiotic therapy selected with AtbFinder in adult patients with cystic fibrosis showed good efficacy in clearing Pseudomonas aeruginosa, reducing pulmonary exacerbations, and decreasing the number of systemic antibiotic courses, resulting in improved lung function.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Alexey V. Stepanov, Roman S. Kalinin, Victoria O. Shipunova, Ding Zhang, Jia Xie, Yuri P. Rubtsov, Valeria M. Ukrainskaya, Alexey Schulga, Elena V. Konovalova, Dmitry V. Volkov, Igor A. Yaroshevich, Anastasiia M. Moysenovich, Alexey A. Belogurov, Hongkai Zhang, Georgij B. Telegin, Alexandr S. Chernov, Mikhail A. Maschan, Stanislav S. Terekhov, Peng Wu, Sergey M. Deyev, Richard A. Lerner, Alexander G. Gabibov, Sidney Altman
Summary: The development of chimeric antigen receptor (CAR) T cell therapy is an important milestone in modern cancer treatment. However, the safety and efficacy of CAR T cell therapy against solid tumors are challenging. This study adopted the high affinity and capability of the bacterial toxin-antitoxin barnase-barstar system to guide CAR T cells to solid tumors, providing a switchable targeting approach for precise control of CAR T cell cytotoxicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Urology & Nephrology
George V. Tetz, Kristina M. Kardava, Maria F. Vecherkovskaya, Michael D. Tsifansky, Victor V. Tetz
Summary: We present a case of a 46-year-old patient with recurrent urinary tract infection that persisted for over 2 years after renal cancer surgery. Despite multiple rounds of antibiotics, including broad-spectrum drugs selected through conventional antibiotic susceptibility testing, the patient experienced multiple reinfections. Successful treatment was achieved when antibiotics were selected using AtbFinder, which identifies antibiotics targeting the mixture of bacteria at the infection site. This case demonstrates the effectiveness of AtbFinder in selecting appropriate antibiotics for relapsing urinary tract infections.
UROLOGY CASE REPORTS
(2023)
Editorial Material
Microbiology
George Tetz, Victor Tetz
FUTURE MICROBIOLOGY
(2023)
Article
Engineering, Biomedical
Alexey V. Stepanov, Jia Xie, Qiaoqiao Zhu, Zuyuan Shen, Wenji Su, Letian Kuai, Richard Soll, Christoph Rader, Geramie Shaver, Lacey Douthit, Ding Zhang, Roman Kalinin, Xiang Fu, Yingying Zhao, Tian Qin, Phil S. Baran, Alexander G. Gabibov, David Bushnell, Dario Neri, Roger D. Kornberg, Richard A. Lerner
Summary: The tumour-targeting activity and specificity of CAR T cells can be regulated by a small-molecule adapter that selectively binds to a hapten and a chosen tumour antigen, offering potential improvements for CAR-based cellular immunotherapies.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
D. V. Volkov, V. M. Stepanova, Y. P. Rubtsov, A. G. Gabibov
Summary: CD45 plays a crucial role in immune cell signal transmission. Imbalances in CD45 can lead to immunodeficiency, autoimmune disorders, and oncological diseases. Understanding the structure and function of CD45 is important for studying oncological diseases and the impact of CD45 on lymphocytes and T cells modified by chimeric antigen receptors.
Review
Biochemistry & Molecular Biology
A. A. Moraleva, A. S. Deryabin, Yu P. Rubtsov, M. P. Rubtsova, O. A. Dontsova
Summary: The formation of eukaryotic ribosomes involves a sequential process of maturation in different cellular compartments. Ribosomal biogenesis factors and ribosomal proteins play key roles in this process. Studies on yeast cells have provided insights into ribosome assembly, but humans have a more complex process. Understanding the mechanisms of human ribosome assembly is important for genetic diseases and tumor suppression.
Review
Biochemistry & Molecular Biology
A. A. Moraleva, A. S. Deryabin, Yu P. Rubtsov, M. P. Rubtsova, O. A. Dontsova
Summary: Ribosome biogenesis is a consecutive coordinated process involving the maturation of ribosomal precursors in different cellular compartments. It requires numerous factors to ensure proper ribosomal RNA processing, structure, and interaction with proteins. In human cells, this process is more complex due to the larger size of ribosomes and pre-ribosomes, as well as intricate regulatory pathways.