Review
Immunology
Hannah Murphy, Hinh Ly
Summary: In this article, we provide a literature review on the current understanding of the basic mechanism of immune responses to LASV infection in animal models and patients, as well as several candidate vaccines.
Review
Infectious Diseases
Maria G. Frank, Adam Beitscher, Camille M. Webb, Vanessa Raabe
Summary: This article provides a clinical perspective on South American Hemorrhagic Fevers (SAHF), focusing on pathogenesis, clinical features, diagnostics, as well as potential therapies and vaccines. The research identified several treatments and a vaccine platform with potential benefits for treating or preventing SAHF in humans, offering valuable information for clinicians facing patients with the disease.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Lisa Oestereich, Helena Mueller-Kraeuter, Elisa Pallasch, Thomas Strecker
Summary: A study demonstrates that polyclonal antibodies purified from rabbit serum have a protective effect against Lassa virus infection, providing potential treatment options for this highly pathogenic virus.
Review
Medicine, Research & Experimental
Eduardo H. S. Bezerra, Talita D. Melo-Hanchuk, Rafael Elias Marques
Summary: This article comprehensively reviews the biology of the Brazilian mammarenavirus, or Sabia virus (SABV), and compares it with related Old World and New World arenaviruses. The study suggests that SABV is likely transmitted to humans through exposure to rodent urine and feces in peri-urban areas. The analysis of SABV proteins reveals potential therapeutic targets and strategies against arenaviruses. Additionally, the article emphasizes the importance of protein structure prediction and analysis in advancing research on SABV and similar viruses.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Morgan Brisse, Claudia Fernandez-Alarcon, Qinfeng Huang, Natalie Kirk, Mark R. Schleiss, Yuying Liang, Hinh Ly
Summary: In this study, a new animal model of virus-induced sensorineural hearing loss was developed by infecting outbred guinea pigs with Pichinde virus. This model can be used to evaluate potential therapeutics for virus-induced hearing impairment in a conventional laboratory setting.
Article
Fisheries
Jiayao Song, Xiaoyu Liu, Cuiling Wu, Yu Zhang, Ke Fan, Xiaodong Zhang, Yongwei Wei
Summary: A strain of Vibrio diabolicus named SX-2018 was isolated from Callista chinensis in the Zhejiang coastal region of China. The strain showed high pathogenicity towards Gomphina aequilatera, but did not exhibit pathogenicity towards other species tested. Analysis of virulence-related gene sequences showed similarities to known strains of V. diabolicus and other Vibrio species.
Article
Immunology
Stephen R. Welch, Sarah C. Genzer, Joann D. Coleman-McCray, Jessica R. Harmon, Florine E. M. Scholte, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: Lassa fever, caused by Lassa virus, is a localized disease endemic to West Africa. This study found that viral RNA and infectious virus can be detected in various specimen types, with conjunctival and nasal specimens yielding the highest amount of infectious virus. These findings suggest the risk of mucosal transmission and highlight the potential utility of RT-qPCR for LASV diagnostics.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Cell Biology
Dominika Bebnowska, Paulina Niedzwiedzka-Rystwej
Summary: Autophagy, a process essential for maintaining organism homeostasis, plays a complex role in viral infections where it can both aid in fighting the virus and facilitate its replication. Further research is needed to fully understand the mechanisms of autophagy in viral infections and its potential use as a therapeutic target. Studies in specific research models are crucial for this purpose.
Review
Pharmacology & Pharmacy
Maria Azparren-Angulo, Felix Royo, Esperanza Gonzalez, Marc Liebana, Bruno Brotons, Jesus Berganza, Felipe Goni-de-Cerio, Nicolo Manicardi, Laia Abad-Jorda, Jordi Gracia-Sancho, Juan M. Falcon-Perez
Summary: The number of publications on Extracellular Vesicles (EVs) released by liver cells has exponentially increased since the first descriptions in 2008, indicating the growing interest in the importance of cell-to-cell communication and the potential of these vesicles in diagnostics and therapeutics. This systematic review summarizes the works from the past decade and discusses the best opportunities for utilizing EVs in liver disease therapeutics.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Houssam Aheget, Loubna Mazini, Francisco Martin, Boutaina Belqat, Juan Antonio Marchal, Karim Benabdellah
Summary: This review provides an overview of the current scientific evidence on the involvement of exosomes in disease pathogenesis, diagnosis, and treatment. Exosomes serve as mediators of intercellular communication and play a significant role in cell biology, with potential applications in diagnosis and therapy. A better understanding of exosome biology could enhance clinical interventions and their use as therapeutic agents.
Article
Immunology
Mathieu Mateo, Jimmy Hortion, Emeline Perthame, Caroline Picard, Stephanie Reynard, Alexandra Journeaux, Clara Germain, Xavier Carnec, Nicolas Baillet, Virginie Borges-Cardoso, Natalia Pietrosemoli, Audrey Vallve, Stephane Barron, Ophelie Jourjon, Orianne Lacroix, Aurelie Duthey, Manon Dirheimer, Mailys Daniau, Catherine Legras-Lachuer, Gregory Jouvion, Caroline Carbonnelle, Herve Raoul, Sylvain Baize
Summary: The circulation of Lassa virus is expanding and a new highly pathogenic lineage VII has emerged in Benin. Both lineage II and lineage VII strains cause inflammation in multiple organs, but lineage VII shows higher virulence with uncontrolled viral replication and imbalanced inflammatory responses. Lineage II has lower virulence but still causes significant symptoms.
Article
Virology
Othmann Merabet, Natalia Pietrosemoli, Emeline Perthame, Jean Armengaud, Jean-Charles Gaillard, Virginie Borges-Cardoso, Mailys Daniau, Catherine Legras-Lachuer, Xavier Carnec, Sylvain Baize
Summary: Lassa virus and Mopeia virus, two closely related arenaviruses, have different immunogenicity and pathogenicity. Lassa virus induces a modest immune response in human umbilical vein endothelial cells (HUVECs), while Mopeia virus induces a late but intense immune response, mainly associated with the expression of genes and proteins related to type I interferon response and antigen processing/presentation.
Review
Biochemistry & Molecular Biology
Hallie N. Pennington, Jinwoo Lee
Summary: Lassa virus, an arenavirus endemic to West Africa, causes a lethal hemorrhagic fever. The virus enters the host cell through a glycoprotein complex, which undergoes conformational changes to mediate membrane fusion and release of genetic material. The fusion protein of Lassa virus has unique features, including a stable signal peptide as a third subunit.
BIOSCIENCE REPORTS
(2022)
Article
Microbiology
Sakthivel Ambreetha, Dananjeyan Balachandar
Summary: This study demonstrates that plant-associated Pseudomonas aeruginosa could pose a potential threat to human health similar to clinical strains. Certain strains isolated from cucumber, tomato, eggplant, and chili exhibited higher virulence and pathogenicity.
Article
Virology
Da Di, Qinfeng Huang, Hinh Ly, Yuying Liang
Summary: Lassa virus (LASV) can cause lethal hemorrhagic fever disease in humans, while other arenaviruses like Pichinde virus (PICV) do not. The Z protein of LASV has been shown to inhibit the innate immune receptor RIG-I, while PICV Z does not. In this study, a stable HeLa cell line was developed to express RIG-I N-terminal effector domain, and recombinant PICVs were generated to compare the effects of LASV Z and PICV Z on viral gene expression and infection. LASV Z showed stronger effects in increasing viral gene expression and infection, especially when RIG-I signaling was activated.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Hannah L. Murphy, Hinh Ly
Summary: Several animal species, including pets like cats and dogs, have been shown to be susceptible to human coronaviruses such as SARS-CoV and SARS-CoV-2. Cats have been found to replicate the virus more efficiently than dogs and can transmit it through aerosols. Ongoing surveillance efforts are crucial to understand the impact of SARS-CoV-2 exposure in animals and the potential zoonotic transmission risks during the COVID-19 pandemic.
Letter
Virology
Hannah Murphy, Hinh Ly
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Da Di, Qinfeng Huang, Hinh Ly, Yuying Liang
Summary: Lassa virus (LASV) can cause lethal hemorrhagic fever disease in humans, while other arenaviruses like Pichinde virus (PICV) do not. The Z protein of LASV has been shown to inhibit the innate immune receptor RIG-I, while PICV Z does not. In this study, a stable HeLa cell line was developed to express RIG-I N-terminal effector domain, and recombinant PICVs were generated to compare the effects of LASV Z and PICV Z on viral gene expression and infection. LASV Z showed stronger effects in increasing viral gene expression and infection, especially when RIG-I signaling was activated.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Hannah Murphy, Shania Sanchez, Shamim Ahmed, Md. Mizanur Rahman, Da Di, Mythili Dileepan, Daniel Heinrich, Yuying Liang, Hinh Ly
Editorial Material
Immunology
Hannah Murphy, Hinh Ly
Article
Immunology
Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Yuying Liang, Hinh Ly, Hiep L. X. Vu
Summary: This study evaluated the feasibility of using rPICV as a viral vector to deliver HA antigen and protect pigs against IAV-S challenge. The results demonstrated that the rPICV-H3 vectored vaccine elicited protective immunity against IAV-S.
Review
Immunology
Hannah Murphy, Hinh Ly
Summary: In this article, we provide a literature review on the current understanding of the basic mechanism of immune responses to LASV infection in animal models and patients, as well as several candidate vaccines.
Editorial Material
Microbiology
Hinh Ly
Editorial Material
Microbiology
Hinh Ly
Letter
Virology
Widaliz Vega-Rodriguez, Hinh Ly
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Virology
Hinh Ly
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to diverse clinical manifestations and pathologies that involve multiple organs. Acute kidney injury in the form of acute tubular necrosis has also been observed in some COVID-19 cases. A recent study provides strong evidence of SARS-CoV-2 infection and tissue injury in renal cells, suggesting an active viral replication in the kidney and a potential role of innate immune cells in renal disease pathogenesis.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Hannah Murphy, Brigitte Flannery, Hinh Ly
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Michaela Cain, Hinh Ly
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Virology
Hinh Ly
JOURNAL OF MEDICAL VIROLOGY
(2023)