Article
Medicine, General & Internal
Cecil J. Weale, Don M. Matshazi, Saarah F. G. Davids, Shanel Raghubeer, Rajiv T. Erasmus, Andre P. Kengne, Glenda M. Davison, Tandi E. Matsha
Summary: This study found that miR-1299, miR-126-3p, and miR-30e-3p are associated with prediabetes, with miR-126-3p showing higher diagnostic capability for prediabetes.
Article
Pharmacology & Pharmacy
Xinmei Cai, Bilian Li, Wei Wei, Yanping Guan, Xue Bai, Min Huang, Yaying Huang, Lili Rong, Xingrong Song, Guoping Zhong
Summary: Our study showed that circulating miR-101-3p, miR-140-3p, and miR-30a-5p could serve as blood-based markers for predicting dexmedetomidine efficacy and safety in pediatric patients, with potential discriminatory ability between responders and non-responders, as well as patients with adverse effects.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Jian Han, Xiaogang Cui, Tianqi Yuan, Zhiming Yang, Yue Liu, Yajuan Ren, Changxin Wu, Yunfei Bian
Summary: Circulating exosomal miRNAs have potential as biomarkers for diagnosis of cardiovascular diseases. In this study, the differentially expressed miRNAs in exosomes from plasma of SCAD patients were analyzed and their diagnostic potential for SCAD was investigated.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell & Tissue Engineering
Lei Peng, Yu Chen, Shaoqing Shi, Heling Wen
Summary: Diabetic nephropathy remains the most common cause of end-stage renal disease, and early diagnosis and treatment can slow down its progression. Circulating levels of kidney-released exosomes and biomolecules have shown potential in predicting the occurrence and progression of diabetic nephropathy. Stem cell therapy and medications targeting inflammatory, oxidant, or pro-fibrotic pathways are being investigated as potential treatments.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkanen
Summary: The study identified plasma miR-9-3p and miR-136-3p as promising biomarker candidates for mTBI, showing potential for distinguishing mTBI patients with high sensitivity and specificity. Further validation in a larger patient population is needed to confirm their diagnostic utility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sofie Dinesen, Alisar El-Faitarouni, Nanna Lond Skov Frisk, Anja Elaine Sorensen, Louise Torp Dalgaard
Summary: Gestational diabetes mellitus (GDM) is a severe complication during pregnancy, and identifying potential biomarkers for its early detection is crucial. This study conducted a systematic review and meta-analysis to investigate miRNAs associated with GDM. The findings suggest that certain miRNAs show altered expression in GDM, indicating their potential as biomarkers for early GDM detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
M. Insenser, A. Quintero, S. de Lope, F. Alvarez-Blasco, M. A. Martinez-Garcia, M. Luque-Ramirez, H. F. Escobar-Morreale
Summary: This research found that the expression of miR-142-3p and miR-598-3p, which are associated with polycystic ovary syndrome (PCOS), differs significantly between women with PCOS and those without. These circulating miRNAs, when combined with easily available measurements such as waist-to-hip ratio (WHR) and circulating LH-to-FSH (LH/FSH) ratios, can effectively distinguish between women with and without PCOS.
HUMAN REPRODUCTION
(2023)
Article
Clinical Neurology
Oh Young Bang, Eun Hee Kim, Mi Jeong Oh, Jaein Yoo, Gyun Sik Oh, Jong-Won Chung, Woo-Keun Seo, Gyeong-Moon Kim, Myung-Ju Ahn, Seong Wook Yang, OASIS-CANCER Study
Summary: This study aimed to evaluate the potential use of extracellular-vesicle-incorporated miRNAs as biomarkers for cancer-related stroke. The results showed that miR-205-5p, miR-645, and miR-646 were specifically incorporated into microvesicles in patients with cancer-related stroke, cancer controls, and stroke controls. The expression levels of these miRNAs could be used to differentiate patients with cancer-stroke from cancer-controls and stroke controls. Further studies are needed to confirm the diagnostic role of miRNAs in stroke patients and to investigate the roles of miRNAs in cancer patients.
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Joon Seok Lee, Gyeong Hwa Kim, Jong Ho Lee, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Keun Hur, Ho Yun Chung
Summary: In this study, miR-365a/b-3p was identified as a potential biomarker for hypertrophic scarring, suggesting its contribution to the formation of hypertrophic scars.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kodai Nakamura, Naomi Hiyake, Tomofumi Hamada, Seiya Yokoyama, Kazuki Mori, Kouta Yamashiro, Mahiro Beppu, Yasuaki Sagara, Yoshiaki Sagara, Tsuyoshi Sugiura
Summary: The study identified a combination of six microRNAs that could accurately distinguish oral squamous cell carcinoma (OSCC) from the control group with a higher degree of accuracy compared to traditional serum tumor markers like SCC-Ag. This specific microRNA panel may serve as a novel candidate biomarker for oral cancer diagnosis.
Article
Medicine, General & Internal
Jingjing Jing, Miao Chang, Shuyi Jiang, Tianlong Wang, Qiuyan Sun, Jun Yang, Chunyan Ma, Tan Li
Summary: The serum level of miR-1-3p was significantly decreased in AAA patients and negatively correlated with inflammatory markers and aneurysm dimensions. MiR-1-3p can be used as a diagnostic biomarker for AAA and plays a crucial role in the development of AAA.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jelena Jankovic Miljus, Maria Augusta Guillen-Sacoto, Jennifer Makiadi-Alvarado, Leon Wert-Lamas, Julia Ramirez-Moya, Mercedes Robledo, Pilar Santisteban, Garcilaso Riesco-Eizaguirre
Summary: This study identified two putative novel miRNAs that rise with rhTSH stimulation in the serums of patients with recurrent/persistent thyroid cancer. However, known miRNAs were not found to be circulating markers for thyroid cancer recurrence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Chunyu Huang, Shuiying Tang, Dong Shen, Xiangzhao Li, Li Liang, Yanqing Ding, Bihong Xu
Summary: This study identified metastasis-associated microRNAs (miRNAs) in plasma exosomes of hepatocellular carcinoma patients. The combination of miR-18a, miR-20b, and miR-221 showed superior prognostic efficacy for distinguishing metastatic from non-metastatic HCC. High expression levels of these candidate miRNAs were associated with poor prognosis, indicating their potential as clinical tools for assessing HCC prognosis.
Review
Medical Laboratory Technology
Giuseppe Lapergola, Alessandro Graziosi, Ebe D'Adamo, Patrizia Brindisino, Mariangela Ferrari, Anna Romanelli, Mariachiara Strozzi, Roberta Libener, Danilo A. W. Gavilanes, Antonio Maconi, Angela Satriano, Alessandro Varrica, Diego Gazzolo
Summary: Recent advances in perioperative management have significantly reduced mortality rate in open heart surgery and cardiopulmonary bypass for heart disease repair. However, the morbidity rate remains unchanged. The measurement of neuro-biomarkers, particularly S100B protein, can be useful in detecting early stage brain damage during the perioperative period. This review provides an updated overview of the pros and cons of using S100B protein for perioperative monitoring in both adult and pediatric patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Bononi, Paola Tedeschi, Vanessa Mantovani, Annalisa Maietti, Elisa Mazzoni, Cecilia Pancaldi, Vincenzo Brandolini, Mauro Tognon
Summary: This study established a cellular model using fluorescent-engineered keratinocyte cell lines to investigate the protective effect of resveratrol against oxidant-induced cytotoxicity. The results demonstrated that cells pre-incubated with resveratrol were able to reverse the oxidative damage caused by the free radical promoter.
Article
Engineering, Biomedical
Philipp Globig, Regine Willumeit-Roemer, Fernanda Martini, Elisa Mazzoni, Berengere J. C. Luthringer-Feyerabend
Summary: This study found that magnesium-based materials can induce a dormant state in osteosarcoma cells, leading to inhibition of tumor cell proliferation. This dormant state can be reversed by reseeding on non-degrading materials.
BIOACTIVE MATERIALS
(2022)
Article
Oncology
Marika Sculco, Marta La Vecchia, Anna Aspesi, Giulia Pinton, Michela G. Clavenna, Elisabetta Casalone, Alessandra Allione, Federica Grosso, Roberta Libener, Alberto Muzio, Ottavio Rena, Guido Baietto, Sara Parini, Renzo Boldorini, Daniela Giachino, Mauro Papotti, Giorgio Scagliotti, Enrica Migliore, Dario Mirabelli, Laura Moro, Corrado Magnani, Daniela Ferrante, Giuseppe Matullo, Irma Dianzani
Summary: This study aimed to search for new predisposing genes and assess the prevalence of pathogenic variants (PVs) in DNA repair genes in 113 unselected patients with malignant pleural mesothelioma (MPM), and evaluate the sensitivity of these patients to tailored treatments. The researchers identified PVs in approximately 7% of the MPM patients, mainly in genes involved in DNA repair. In vitro studies showed that a specific treatment induced apoptosis in MPM cells with DNA repair insufficiency. These findings suggest the potential benefits of personalized treatments for MPM patients with DNA repair defects.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Immunology
Ilaria Bononi, Elisa Mazzoni, Silvia Pietrobon, Maria Rosa Iaquinta, Andrea Caselli, Elena Torreggiani, Maura Pugliatti, Ilaria Casetta, Massimiliano Castellazzi, Enrico Granieri, Fernanda Martini, Mauro Tognon
Summary: This study aimed to investigate the association between the polyomavirus BKPyV and MS, along with other neurological diseases. The results showed that MS patients and other inflammatory neurological diseases had a lower prevalence and titer of IgG antibodies against BKPyV VP 1 epitopes compared to healthy subjects. This suggests specific immunologic dysfunctions for BKPyV in neurological disorders.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Elisa Mazzoni, Ilaria Bononi, John Charles Rotondo, Chiara Mazziotta, Roberta Libener, Roberto Guaschino, Roberta Gafa, Giovanni Lanza, Fernanda Martini, Mauro Tognon
Summary: Malignant pleural mesothelioma (MPM) is associated with asbestos exposure, and the study found a link between MPM and simian virus 40 (SV40), with the expression of SV40 in line with the detection of antibodies in patients.
JOURNAL OF ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Maria Rosa Iaquinta, Fernanda Martini, Antonio D'Agostino, Lorenzo Trevisiol, Massimo Bersani, Elena Torreggiani, Mauro Tognon, John Charles Rotondo, Elisa Mazzoni
Summary: Bone defects in maxillofacial regions can cause deformity and dysfunction. The use of biomaterials/scaffolds for maxillofacial bone regrowth has attracted interest from surgical specialties. This study found differential expression of genes in human adipose derived-mesenchymal stem cells cultured on a specific scaffold, suggesting its potential use in maxillofacial surgery. The scaffold offers the advantage of personalized medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Microbiology
John Charles Rotondo, Fernanda Martini, Martina Maritati, Elisabetta Caselli, Carla Enrica Gallenga, Matteo Guarino, Roberto De Giorgio, Chiara Mazziotta, Maria Letizia Tramarin, Giada Badiale, Mauro Tognon, Carlo Contini
Summary: COVID-19 emerged in late 2019 in China and quickly spread across the globe, causing significant impacts. Over the past 2 years, there have been important advancements in prevention and diagnosis, such as the development of effective vaccines and high sensitivity diagnostic kits.
Article
Immunology
Chiara Mazziotta, Carmen Lanzillotti, Marcello Govoni, Simonetta Falzoni, Maria Letizia Tramarin, Elisa Mazzoni, Mauro Tognon, Fernanda Martini, John Charles Rotondo
Summary: A study found that Merkel cell polyomavirus (MCPyV) spreads widely and symptom-free in humans. By studying the serum of healthy children and young adults, it was found that their levels of MCPyV immunoglobulin G (IgG) and IgM antibodies are relatively high. Furthermore, there are variations in the levels of MCPyV IgG and IgM among different age groups.
Review
Virology
Chiara Mazziotta, Christian Felice Cervellera, Carmen Lanzillotti, Antoine Touze, Pauline Gaboriaud, Mauro Tognon, Fernanda Martini, John Charles Rotondo
Summary: Merkel cell carcinoma has two distinct etiologies, one caused by Merkel cell polyomavirus and another induced by UV exposure. This review discusses the dysregulation of miRNAs in MCC and their potential clinical application as diagnostic and prognostic biomarkers, aiming to improve MCC options for diagnosis, prognosis, and treatment.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Cell Biology
Chiara Mazziotta, Mauro Tognon, Fernanda Martini, Elena Torreggiani, John Charles Rotondo
Summary: Immune cells and commensal microbes in the human intestine communicate and react with each other to maintain healthy immune activities. Probiotic bacteria can stimulate immune cells and microflora to modulate immune functions and homeostasis. The use of probiotics has potential for improving immune system activities.
Article
Engineering, Biomedical
Philipp Globig, Roshani Madurawala, Regine Willumeit-Roemer, Fernanda Martini, Elisa Mazzoni, Berengere J. C. Luthringer-Feyerabend
Summary: Cancer metastases are the leading cause of cancer-related deaths, and traditional treatment methods often come with side effects. Recent studies have shown that specially designed degradable magnesium alloys can reduce cancer cell proliferation and inhibit different steps of cancer metastasis, including cell migration, invasion, and angiogenesis.
BIOACTIVE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Giulia Di Mauro, Francesca Frontini, Elena Torreggiani, Maria Rosa Iaquinta, Andrea Caselli, Chiara Mazziotta, Valentina Esposito, Elisa Mazzoni, Roberta Libener, Federica Grosso, Antonio Maconi, Fernanda Martini, Ilaria Bononi, Mauro Tognon
Summary: The epigenetic role of circulating miR-197-3p in malignant pleural mesothelioma (MPM) patients was investigated. It was found that miR-197-3p levels were significantly higher in MPM patients, suggesting it as a potential biomarker for early diagnosis of MPM.
SCIENTIFIC REPORTS
(2023)
