Article
Biochemistry & Molecular Biology
Snezana Hinic, April Rich, Nicole Anayannis, Stephanie Cabarcas-Petroski, Laura Schramm, Patricio Meneses
Summary: High-risk human papillomaviruses (HPV) play a significant role in the development of head and neck squamous cell carcinomas (HNSCC), and are associated with differential gene expression and DNA methylation patterns. The study identified differential gene expression, differential methylation, and altered pathways between HPV positive and HPV negative HNSCC groups, highlighting genes such as SYCP2 and TAF7L that are implicated in HPV positive HNSCC tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yoshikuni Inokawa, Masamichi Hayashi, Shahnaz Begum, Maartje G. Noordhuis, Daivd Sidransky, Joseph Califano, Wayne Koch, Mariana Brait, William H. Westra, Mohammad O. Hoque
Summary: AGTR1 and FHIT methylation can serve as suitable detection markers for OPSCCs derived from the HPV-infected field, showing associations with p16-positive and RB-negative phenotypes. These markers have high sensitivity and are linked to better overall survival outcomes.
Article
Pathology
Sigrid Regauer, Olaf Reich, Karl Kashofer
Summary: This study provides a detailed characterization of HPV-negative cervical carcinoma, including the identification of different types of precursor lesions and the analysis of genetic mutations and chromosomal variations. The findings suggest that genetic factors and inflammatory infiltrate may contribute to the development of HPV-negative cervical cancer.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Barbora Pokryvkova, Jana Smahelova, Natalie Dalewska, Marek Grega, Ondrej Vencalek, Michal Smahel, Jaroslav Nunvar, Jan Klozar, Ruth Tachezy
Summary: The study evaluated the expression of tumor-associated macrophages (TAMs) in head and neck squamous cell carcinoma, finding a higher presence of pro-tumorigenic M2 in HPV- tumors and a non-macrophage population expressing ARG1 in both compartments. Furthermore, the mRNA expression of ARG1 was identified as a negative prognostic factor for overall survival of HNSCC patients.
Article
Microbiology
Chukkris Heawchaiyaphum, Tipaya Ekalaksananan, Natcha Patarapadungkit, Suchin Worawichawong, Chamsai Pientong
Summary: The down-regulation of tumor-suppressive miR-145 has been found to be significantly associated with EBV and HPV infection in oral squamous-cell carcinoma, possibly influencing miR-145 promoter methylation through the induction of DNMT3B. The prevalence of EBV and HPV co-infection was significantly higher in tumors compared to normal tissues in OSCC. EBV alone or jointly with HPV may play a role in the down-regulation of miR-145 and the modulation of DNMT3B expression in OSCC.
Article
Health Care Sciences & Services
Pei-Hung Chang, Hung-Ming Wang, Yung-Chia Kuo, Li-Yu Lee, Chia-Jung Liao, Hsuan-Chih Kuo, Cheng-Lung Hsu, Chun-Ta Liao, Sanger Hung-Chi Lin, Pei-Wei Huang, Tyler Min-Hsien Wu, Jason Chia-Hsun Hsieh
Summary: The study investigated the prognostic value of p16-positive and p16-negative circulating tumor cells (CTCs) in head and neck squamous cell carcinoma (HNSCC) patients undergoing definitive chemoradiotherapy. The presence of p16-positive CTCs was associated with better responses to treatment and improved disease progression, while p16-negative CTCs were linked to disease progression. It suggested that CTC testing could help predict outcomes and guide treatment decisions in HNSCC patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Anders Berglund, Clarisse Muenyi, Erin M. Siegel, Abidemi Ajidahun, Steven A. Eschrich, Denise Wong, Leah E. Hendrick, Ryan M. Putney, Sungjune Kim, D. Neil Hayes, David Shibata
Summary: HPV16 and other HPV types within the same alpha species exhibit distinct methylation profiles in head and neck squamous cell carcinomas (HNSCC). Understanding these differences could provide insights into the clinical behavior of HPV-associated HNSCC and contribute to a better understanding of the biological mechanisms underlying HPV-related tumors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Oncology
Kate Chatfield-Reed, Veronique P. Roche, Quintin Pan
Summary: High-risk HPV is a factor in various squamous cell carcinomas and its cfDNA levels can be indicative of poor prognosis and treatment relapse. Longitudinal sampling has shown that persistent or increasing HPV cfDNA levels can predict treatment failures. Using a liquid biopsy platform for HPV cfDNA may have clinical utility in HPV+ cancer patients.
Article
Cell Biology
Nuria Carreras-Dieguez, Adela Saco, Marta del Pino, Lorena Marimon, Ricardo Lopez del Campo, Carolina Manzotti, Pere Fuste, Claudia Pumarola, Aureli Torne, Adriana Garcia, Natalia Rakislova
Summary: Based on the 2020 WHO classification, vulvar squamous cell carcinomas (VSCC) are divided into HPV-associated and HPV-independent types, with further division based on p53 status. This study analyzed the clinical and prognostic characteristics of these three types of VSCC in a large group of patients.
Article
Oncology
Jan Niklas Mink, Oybek Khalmurzaev, Alexey Pryalukhin, Carol Immanuel Geppert, Stefan Lohse, Kristof Bende, Joao Lobo, Rui Henrique, Hagen Loertzer, Joachim Steffens, Carmen Jeronimo, Heiko Wunderlich, Julia Heinzelbecker, Rainer M. Bohle, Michael Stoeckle, Vsevolod Matveev, Arndt Hartmann, Kerstin Junker
Summary: This study evaluated 297 penile cancer patients from Germany, Russia, and Portugal and found a significant association between lymph node metastasis and lymphovascular invasion with prognosis. The current TNM classification was not found to improve prognosis estimation. Revision of the TNM classification is suggested.
Article
Oncology
Farah Succaria, Pia Kvistborg, Julie E. Stein, Elizabeth L. Engle, Tracee L. McMiller, Lisa M. Rooper, Elizabeth Thompson, Alan E. Berger, Michiel van den Brekel, Charlotte L. Zuur, John Haanen, Suzanne L. Topalian, Janis M. Taube
Summary: Approximately 15% of advanced head and neck squamous cell carcinomas respond to anti-PD-(L)1 monotherapies, with tumor PD-L1 expression and human papillomavirus (HPV) status proposed as biomarkers to identify patients likely to benefit. The study found that HPV-positive HNSCC tumors had significantly higher densities of certain immune cells compared to HPV-negative tumors, and that there was no variation in PD-L1 expression patterns based on tumor viral status.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Genetics & Heredity
Elena N. Voropaeva, Tatjana Pospelova, Yuriy L. Orlov, Maria Churkina, Olga Berezina, Anna A. Gurazheva, Tatjana A. Ageeva, Olga B. Seregina, Vladimir N. Maksimov
Summary: This study investigated the methylation status of MIR-203, MIR-129-2, MIR-34A, and MIR-34B/C genes in diffuse large B-cell lymphoma (DLBCL) tumor tissue. The results showed that the methylation of these genes is frequent in DLBCL and associated with prognosis and treatment response.
Article
Oncology
Nikki B. Thuijs, Willemijn A. M. Schonck, Linde L. J. Klaver, Guus Fons, Marc van Beurden, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: In this exploratory study, biomarker profiles in patients with multiple high-risk HPV-associated vulvar precursor lesions were compared. While the biomarkers generally showed similar expression between lesions, marked differences were occasionally observed, indicating heterogeneity within multifocal lesions. This study contributes to a better understanding of the potential diagnostic, prognostic, and predictive value of biomarkers in patients with multifocal HSIL.
Article
Oncology
Natalia Rakislova, Nuria Carreras-Dieguez, Carolina Manzotti, Ofelia Saude, Marta del Pino, Laurina Chulo, Ricardina Rangeiro, Lucilia Lovane, Cesaltina Lorenzoni, Fabiola Fernandes, Maria Teresa Rodrigo-Calvo, Sherley Diaz-Mercedes, Inmaculada Ribera-Cortada, Esther Sanfeliu, Ricardo Lopez del Campo, Lorena Marimon, Silvia Alos, Naiara Vega, Francisco M. Perez, Isabel Trias, Carla Carrilho, Jaume Ordi
Summary: This study compared the etiopathogenic features of HPV-related and HPV-independent vulvar squamous cell carcinomas (VSCC) in Mozambique and Spain. The results showed that in Mozambique, 97% of tumors were HPV-associated with younger age, while in Spain, only 19% of tumors were HPV-associated with older age.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Carolina Manzotti, Laurina Chulo, Ricardo Lopez del Campo, Isabel Trias, Marta del Pino, Ofelia Saude, Iracema Basilio, Nelson Tchamo, Lucilia Lovane, Cesaltina Lorenzoni, Fabiola Fernandes, Adela Saco, Maria Teresa Rodrigo-Calvo, Lorena Marimon, Mamudo R. Ismail, Carla Carrilho, Inmaculada Ribera-Cortada, Jaume Ordi, Natalia Rakislova
Summary: This study compares the etiopathogenic features of penile squamous cell carcinomas (PSCC) from Mozambique and Spain. The results show significant differences in age distribution and HPV association between the two countries. These findings have important implications for primary prevention of PSCC worldwide.
Article
Medicine, Research & Experimental
Marina Z. Jovanovic, David A. Geller, Nevena M. Gajovic, Milena M. Jurisevic, Nebojsa N. Arsenijevic, Milan M. Jovanovic, Gordana M. Supic, Danilo V. Vojvodic, Ivan P. Jovanovic
Summary: Co-blockage of IL33/ST2 and PD-L/PD-1 axes impedes tumor progression more efficiently than single blockage of either axes, thus offering potential new approach to immunotherapy of tumors.
Article
Oncology
Marija Dunjic, Nikola Lukic, Boban Djordjevic, Bojana Uzelac, Nikola Ostojic, Gordana Supic
Summary: This study revealed an association between genetic polymorphisms in the GLI1 gene of the sonic hedgehog (SHH) signaling pathway and prognosis of melanoma skin cancer patients. It found that patients with a specific GLI1 variant genotype had poorer overall survival and recurrence-free survival. Additionally, carriers of mutated alleles in GLI1 were found to have an increased risk of melanoma. This suggests GLI1 could serve as a novel marker for melanoma prognosis and a potential drug target for anti-cancer treatment.
Review
Biochemistry & Molecular Biology
Dusan M. Maric, Gordana Velikic, Dusica L. Maric, Gordana Supic, Danilo Vojvodic, Vedrana Petric, Dzihan Abazovic
Summary: Transplanted stem cells can be directed to migrate to targeted tissues through direct delivery to the cerebrospinal fluid. However, the efficiency and mechanisms of this method still need improvement, and there is a discrepancy between in vivo and in vitro results, as well as a gap between preclinical and clinical research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Danilo Jokovic, Filip Milosavljevic, Zvezdana Stojanovic, Gordana Supic, Danilo Vojvodic, Bojana Uzelac, Marin M. Jukic, Aleksandra Petkovic Curcin
Summary: The inter-individual variability in CYP2C19-mediated metabolism can impact the effectiveness and tolerability of antidepressant treatment. This study found that individuals with slow metabolism showed lower antidepressant efficacy and tolerability compared to normal metabolizers, possibly due to their reduced capacity to metabolize antidepressant drugs.
PSYCHIATRY RESEARCH
(2022)
Article
Oncology
Nikola Ostojic, Tatjana Radevic, Lidija Kandolf Sekulovic, Boban Djordjevic, Ljiljana Jaukovic, Nenad Stepic, Gordana Supic
Summary: In this study, the association between polymorphisms in TLR3 and TLR4 genes and clinicopathologic features, progression, and survival of melanoma patients was investigated. The results suggest that TLR4 polymorphisms T399I and D299G could serve as potential prognostic and survival markers for melanoma patients.
Article
Medicine, General & Internal
Milka F. Gardasevic, Aleksandra Petkovic-Curcin, Danilo V. Vojvodic, Uros Marjanovic, Dragan Djurdjevic, Sasa Jovic, Dejan Vulovic, Stevo Matijevic
Summary: This study aimed to investigate the effect of using platelet-rich plasma (PRP) in facial nerve repair. By dividing the experimental animals into four groups and observing the extent of repair and indicators of regeneration, it was found that the PRP treatment group showed better promotion of facial nerve regeneration.
VOJNOSANITETSKI PREGLED
(2023)
Article
Oncology
Andjela R. Petrovic, Ivan P. Jovanovic, Milena M. Jurisevic, Marina Z. Jovanovic, Marina M. Jovanovic, Sladjana P. Pavlovic, Nebojsa N. Arsenijevic, Gordana M. Supic, Danilo V. Vojvodic, Milan M. Jovanovic, Nevena M. Gajovic
Summary: The study found that metformin can directly enhance the activation and cytotoxicity of natural killer (NK) cells. This finding may contribute to dissecting key mechanisms of metformin exerting antitumor activity and advancing the use of metformin as an antitumor agent.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, General & Internal
Gordana Ostojic, Gordana Supic, Vukoica Karlicic, Marija Karlicic, Elizabeta Ristanovic, Milan Kovacevic, Dzihan Abazovic, Dragana Gojkov, Ivan Stanojevic, Miroslav Vukosavljevic, Danilo Vojvodic
Summary: This study suggests that treatment with blood plasma rich in specific antibodies could be a safe and effective therapy for COVID-19 patients. The study also found that antibody concentrations increased over time in recovered patients.
VOJNOSANITETSKI PREGLED
(2022)
Article
Medicine, General & Internal
Sasa Jovic, Ruzica Kozomara, Srboljub Stosic, Stevo Jovandic, Katarina Zeljic, Gordana Supic
Summary: TP53 gene mutations are associated with survival and chemotherapy response in HPV-negative OSCC patients.
VOJNOSANITETSKI PREGLED
(2022)
Meeting Abstract
Immunology
M. Jovanovic, D. Geller, N. Gajovic, M. Jurisevic, N. Arsenijevic, M. Jovanovic, G. Supic, D. Vojvodic, I. Jovanovic
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)