Article
Chemistry, Multidisciplinary
Kurt Wagner, Muhammad A. Sami, Corey Norton, Jonathan McCoy, Umer Hassan
Summary: The study evaluated the relationship between blood lactate levels and neutrophil phagocytic activity at a single-cell level, revealing higher phagocytic activity in the high-risk group. Although interesting findings were highlighted, further integration of individual medical records is needed for personalized insights into phagocytic activity.
Article
Immunology
Judith Schenz, Manuel Obermaier, Sandra Uhle, Markus Alexander Weigand, Florian Uhle
Summary: An ongoing challenge in sepsis research is elucidating the mechanisms contributing to the dysregulated host response to infection. Depleting CD15(+) cells after density gradient centrifugation is a feasible method to improve the purity and functionality of isolated peripheral blood mononuclear cells from septic patients, ensuring good comparability between different studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Woon Yong Kwon, Gil Joon Suh, Yoon Sun Jung, Seung Min Park, Subi Oh, Sung Hee Kim, A. Rum Lee, Jeong Yeon Kim, Hayoung Kim, Kyung Ah Kim, Young Kim, Byoung Choul Kim, Taegyun Kim, Kyung Su Kim, Kiyoshi Itagaki, Carl J. Hauser
Summary: The study revealed a strong association between circulating ND6 levels in patients with septic shock and the development of secondary infection, as well as increased mortality rates. Suppression of PMN chemotaxis may play a key role in the increased susceptibility to secondary infection in these patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Huibert-Jan Joosse, Albert Huisman, Wouter van Solinge, Falco Hietbrink, Imo Hoefer, Saskia Haitjema
Summary: Neutrophils play an important role in the immune response, but their function and population can be altered in different disease states. We compared the characteristics of neutrophil populations in sepsis and trauma patients using data-driven methods and found that trauma patients had an inability to flag band neutrophils, which may be explained by their smaller size increase and higher nuclear segmentation.
Article
Surgery
Yurie Futoh, Yuko Kumagai, Hideyo Miyato, Hideyuki Ozawa, Rihito Kanamaru, Ai Sadatomo, Yasuharu Ohnishi, Koji Koinuma, Hisanaga Horie, Hironori Yamaguchi, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Summary: This study evaluated the impact of increased low-density granulocytes (LDGs) on the survival of patients with colorectal cancer (CRC) who underwent radical surgery. The study found that the postoperative proportion of LDGs was significantly correlated with recurrence and suggested that the proportion of LDGs could be a useful biomarker to select the specific subgroup of patients most likely to benefit from adjuvant chemotherapy.
Article
Medicine, Research & Experimental
Rose-Marie Rebillard, Marc Charabati, Camille Grasmuck, Abdelali Filali-Mouhim, Olivier Tastet, Nathalie Brassard, Audrey Daigneault, Lyne Bourbonniere, Sai Priya Anand, Renaud Balthazard, Guillaume Beaudoin-Bussieres, Romain Gasser, Mehdi Benlarbi, Ana Carmena Moratalla, Yves Carpentier Solorio, Marianne Boutin, Negar Farzam-kia, Jade Descoteaux-Dinelle, Antoine Philippe Fournier, Elizabeth Gowing, Annemarie Laumaea, Helene Jamann, Boaz Lahav, Guillaume Goyette, Florent Lemaitre, Victoria Hannah Mamane, Jeremie Prevost, Jonathan Richard, Karine Thai, Jean-Francois Cailhier, Nicolas Chomont, Andres Finzi, Michael Chasse, Madeleine Durand, Nathalie Arbour, Daniel E. Kaufmann, Alexandre Prat, Catherine Larochelle
Summary: Dysregulation of immune cell subsets was found in both acute SARS-CoV-2 infection and non-COVID-19 related acute illnesses, while specific differences were identified in certain myeloid and lymphocyte subsets associated with SARS-CoV-2 status. Some SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days, and mortality.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita
Summary: The expression of CEACAM1 is elevated in peripheral blood neutrophils of patients with RA and is associated with rheumatoid inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Rashi Sehgal, Navkiran Kaur, Rakhi Maiwall, Gayatri Ramakrishna, Jaswinder Singh Maras, Nirupma Trehanpati
Summary: This study found that the faulty functionality of neutrophils in decompensated cirrhosis patients may be due to autophagy proteins, which could serve as therapeutic targets.
Article
Gastroenterology & Hepatology
Rakhi Maiwall, Samba Siva Rao Pasupuleti, Ashini Kumar Hidam, Anupam Kumar, Harsh Vardhan Tevethia, Rajan Vijayaraghavan, Arpita Majumdar, Adarsh Prasher, Sherin Thomas, Rajendra Prasad Mathur, Guresh Kumar, Shiv Kumar Sarin
Summary: This study compared the efficacy of a high mean arterial pressure (MAP) strategy to a low MAP strategy in patients with cirrhosis and septic shock. The results showed that a higher MAP strategy did not improve 28-day mortality, but it improved tolerance to dialysis and renal recovery, and was associated with more adverse events.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Pacome Lecot, Maude Ardin, Sebastien Dussurgey, Vincent Alcazer, Lyvia Moudombi, Manuela Pereira Abrantes, Margaux Hubert, Aurelie Swalduz, Hector Hernandez-Vargas, Alain Viari, Christophe Caux, Marie-Cecile Michallet
Summary: The study found the existence of neutrophil-platelet aggregates (NPAs) in the blood of cancer patients, which have unique molecular characteristics compared to other neutrophil subsets. The neutrophil transcriptomic signature associated with NPAs was correlated with a worse prognosis in various cancer types, suggesting a potential role in cancer progression.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Mariam Murad, Liying Low, Matthew Davidson, Philip Murray, Saaeha Rauz, Graham R. Wallace
Summary: The study revealed reduced phagocytic capacity and reactive oxygen species (ROS) production but increased neutrophil extracellular traps (NET) production in total neutrophils stimulated with PMA or E.coli from BD patients compared to healthy controls. BD patients had more LDN and fewer NDN compared to healthy controls, and both neutrophil subsets showed reduced ROS production and phagocytic function similar to total neutrophils in both groups. These findings suggest that the heterogeneous neutrophil population in BD, with increased numbers of LDN and greater NET production, may contribute to the inflammatory response and pathogenesis.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Maaike Cockx, Marfa Blanter, Mieke Gouwy, Pieter Ruytinx, Sara Abouelasrar Salama, Sofie Knoops, Noemie Poertner, Lotte Vanbrabant, Natalie Lorent, Mieke Boon, Sofie Struyf
Summary: Investigations on patients with primary ciliary dyskinesia (PCD) revealed that neutrophils in their peripheral blood produce fewer reactive oxygen species upon stimulation with bacterial products or cytokines, and show reduced capacity in releasing DNA during neutrophil extracellular trap formation. These findings suggest that the reduced neutrophil activity in PCD patients may contribute to recurrent respiratory infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zuzana Parackova, Irena Zentsova, Marketa Bloomfield, Adam Klocperk, Rudolf Horvath, Hana Malcova, Dita Cebecauerova, Anna Sediva
Summary: This study analyzed gene expression of PBMCs in children with JIA and found that LDNs existed in patients' PBMCs with altered gene expression and release of products. LDNs were described as primed, degranulated, immature cells with impaired suppressive activities, correlated with serum calprotectin levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caspar Mewes, Julius Runzheimer, Carolin Boehnke, Benedikt Buettner, Marcus Nemeth, Jose Hinz, Michael Quintel, Ashham Mansur
Summary: This study compared the mortality and sepsis-associated organ dysfunction between patients with sepsis following surgical intervention and those with sepsis without prior surgery. The results showed that non-surgical patients had a higher mortality rate and more severe organ dysfunction compared to surgical patients. These findings have important implications for clinical decision-making, patient management, and resource allocation in sepsis care.
Review
Immunology
Zujin Xu, Anpeng Liu, Liu Yang, Bin Zhang, Feng Zheng, Jingjing Zhang, Jia Zhan
Summary: Although the mortality rate of sepsis decreases annually, sepsis is still one of the most common causes of death in hospitals. Specific treatments have not been researched yet because of the dynamical pathophysiological process and the individual differences.
CLINICAL IMMUNOLOGY
(2022)