Article
Biochemistry & Molecular Biology
Christin Weissleder, Hayley F. North, Maina Bitar, Janice M. Fullerton, Rachel Sager, Guy Barry, Michael Piper, Glenda M. Halliday, Maree J. Webster, Cynthia Shannon Weickert
Summary: The study found that the human SEZ retains the capacity to generate neuronal progenitor cells throughout life, but this capacity is limited in schizophrenia and bipolar disorder. Increased macrophages in the SEZ of schizophrenia patients may impair neurogenesis.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemical Research Methods
Alma Andersson, Joakim Lundeberg
Summary: In this study, a novel method was proposed to analyze spatial transcriptomics data, which simulated the diffusion of individual transcripts to extract genes with spatial patterns, generating satisfactory results on synthetic and real data. Compared to existing methods, this approach seemed to be less influenced by gene expression levels and showed better time performance when run with multiple cores.
Article
Psychiatry
Hayley F. North, Christin Weissleder, Janice M. Fullerton, Rachel Sager, Maree J. Webster, Cynthia Shannon Weickert
Summary: Inflammation plays a role in regulating neurogenesis, with reduced expression of neurogenesis markers observed in the brains of patients with schizophrenia and bipolar disorder. The study found a significantly higher proportion of these patients in high inflammation subgroups, suggesting a potential link between inflammation and impaired neuronal differentiation in psychiatric disorders.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Medicine, General & Internal
Rachel L. Oren, Rachel H. Grasfield, Matthew B. Friese, Lori B. Chibnik, John H. Chi, Michael W. Groff, James D. Kang, Zhongcong Xie, Deborah J. Culley, Gregory Crosby
Summary: This study investigated the molecular changes in circulating CD14+ monocytes, cells involved in clinical recovery, of older patients after surgery. The results showed that surgery altered the expression of immune-related genes in monocytes, suggesting a development of an immunocompromised/hypoactive phenotype. This signature could potentially serve as a biomarker for predicting poor outcomes in older surgical patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yulin He, Simon Ming Yuen Lee
Summary: Neuroinflammation is a key player in neurological disorders, and this study developed and validated a larval zebrafish model of neuroinflammation using lipopolysaccharide (LPS) injection. The model can be used for studying neuroinflammation and high-throughput drug screening.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Oncology
Min-Ae Song, Kellie M. Mori, Joseph P. Mcelroy, Jo L. Freudenheim, Daniel Y. Weng, Sarah A. Reisinger, Theodore M. Brasky, Mark D. Wewers, Peter G. Shields
Summary: Smoking and electronic cigarette vaping are associated with accelerated lung epigenetic aging, indicating potential adverse effects on biological aging. Further research is needed to understand the unique effects of electronic cigarettes on pulmonary health.
CLINICAL EPIGENETICS
(2023)
Article
Dermatology
Xiaohua Wang, Si Wen, Li Ye, Dan Liu, Mao-Qiang Man, Bin Yang
Summary: This study investigates the changes in gene expression profiles in the epidermis of aged mice using RNA sequencing techniques. The results show an upregulation of genes associated with inflammatory signaling pathways and a downregulation of genes related to metabolic signaling pathways in the epidermis of aged mice.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Genetics & Heredity
Qing Yuan, Fu-Xing Zuo, Hong-Qing Cai, Hai-Peng Qian, Jing-Hai Wan
Summary: A novel gene signature based on differentially expressed genes (DEGs) between glioblastoma (GBM) and healthy subventricular zone (SVZ) was developed for determining GBM patient prognosis. High-risk patients showed significantly reduced overall survival and were associated with lower immune cell counts and higher PD-L1 expression. Targeting these genes may be a therapeutic strategy for GBM.
FRONTIERS IN GENETICS
(2022)
Article
Health Care Sciences & Services
Katarzyna Blizniewska-Kowalska, Piotr Galecki, Janusz Szemraj, Monika Talarowska
Summary: The study found that expression of NGF, BDNF, and REST genes is lower in depressed patients than in the control group, while the expression of the GDNF gene is higher in patients with depressive disorders than in the group of healthy volunteers. These selected genes may serve as a biomarker of depression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Nouf O. AlAfaleq, Tasneem M. Hussein, Samia T. Al-Shouli, Nojood Altwaijry, Mohd Shahnawaz Khan, Aqel Albutti, Maaweya E. Hamed
Summary: Prediabetes is a state of increased risk for diabetes, characterized by elevated blood glucose levels. This study aimed to analyze proinflammatory cytokines in prediabetic patients and investigate their potential role in the development of diabetes. The results showed increased levels of IL-2, IL-1b, and IL-1a in prediabetic patients compared to healthy controls. IL-1a showed a stronger correlation with glucose levels than IL-1b and IL-2. These findings suggest that cytokines, particularly IL-1, may play a critical role in diabetes development.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleah Holmes, Yan Xu, Juneyoung Lee, Michael E. Maniskas, Liang Zhu, Louise D. McCullough, Venugopal Reddy Venna
Summary: Social isolation and loneliness are risk factors for stroke, especially in elderly women. In this study, social isolation immediately after stroke was found to lead to more brain tissue loss, higher mortality, delayed recovery, and worsened cognitive function in aged female mice. Dysregulation of miRNAs and reduced hippocampal cell proliferation were also observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Adrianna Dzidek, Olga Czerwinska-Ledwig, Malgorzata Zychowska, Wanda Pilch, Anna Piotrowska
Summary: SIRT6 is an enzyme involved in protein modification and is considered a longevity protein. It affects various molecular pathways related to aging and is influenced by factors such as diet, weight loss, and exercise. SIRT6 plays a role in wound healing and has different effects on inflammation. It is also affected by exogenous substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Cong Xiao, P. Githure M'Angale, Shuhao Wang, Adrienne Lemieux, Travis Thomson
Summary: Structural synaptic plasticity is crucial for learning and memory, and the protein dArc1 plays a significant role in regulating this process. The study reveals that dArc1 affects multiple cellular processes, including metabolism, phagocytosis, and RNA splicing, thereby acting as a master regulator of plasticity.
Article
Cell & Tissue Engineering
Theodora Mourtzi, Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Charalampos Salodimitris, Konstantinos Botsakis, Danai Kassandra Meri, Maria Anesti, Aggeliki Dimopoulou, Ioannis Charalampopoulos, Achilleas Gravanis, Nikolaos Matsokis, Fevronia Angelatou, Ilias Kazanis
Summary: Our study demonstrated that the alkaline Sudan Red extraction has a significant effect on dihydrotestosterone and diosgenin in the Emei bumblebee bamboo, showing strong anti-estrogenic activity, while the extraction with only diosgenin had relatively low content of alkaline Sudan Red impurities.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shelley L. Forrest, Jordan Hanxi Kim, Daniel R. Crockford, Katharine Huynh, Rosie Cheong, Samantha Knott, Madison A. Kane, Lars M. Ittner, Glenda M. Halliday, Jillian J. Kril
Summary: This study maps the distribution and density of astrocytes in the human frontal cortex, revealing distinct and overlapping populations of astrocytes. The findings provide a reference map for comparative studies in various disease and injury states involving astrocytes.
NEUROCHEMICAL RESEARCH
(2023)
Correction
Clinical Neurology
YuHong Fu, Liche Zhou, Hongyun Li, Jen-Hsiang T. Hsiao, Binyin Li, Onur Tanglay, Andrew D. Auwyang, Elinor Wang, Jieyao Feng, Woojin S. Kim, Jun Liu, Glenda M. Halliday
ACTA NEUROPATHOLOGICA
(2023)
Letter
Clinical Neurology
Srestha Mazumder, Heather McCann, Susan D'Silva, Sarah Furlong, Claire E. Shepherd, Jillian J. Kril, Glenda M. Halliday, Dominic B. Rowe, Matthew C. Kiernan, Rachel H. Tan
Article
Biochemistry & Molecular Biology
Zac Chatterton, Praves Lamichhane, Diba Ahmadi Rastegar, Lauren Fitzpatrick, Helene Lebhar, Christopher Marquis, Glenda Halliday, John B. Kwok
Summary: This study presents a single-cell DNA methylation sequencing method that can accurately resolve the DNA methylation profiles of individual cells. The sciEM method improves sequencing alignment rates, reduces adapter contamination, and over-estimation of DNA methylation levels. The researchers successfully applied this method to resolve single-cell DNA methylation of major cell types in the human brain.
CELL AND BIOSCIENCE
(2023)
Article
Neuroimaging
Nga Yan Tse, Martina Bocchetta, Emily G. Todd, Emma M. Devenney, Sicong Tu, Jashelle Caga, John R. Hodges, Glenda M. Halliday, Muireann Irish, Matthew C. Kiernan, Olivier Piguet, Jonathan D. Rohrer, Rebekah M. Ahmed
Summary: Through studying a large sample of 211 participants, it was found that different subregions of the hypothalamus are correlated with cognitive and behavioral impairments. Patients with ALS, mixed ALS-FTD, and bvFTD all showed hypothalamic involvement. Cognitive and behavioral symptoms were correlated with bilateral involvement of the anterior inferior, anterior superior, and posterior hypothalamic subregions. The anterior superior and superior tuberal subregions displayed the greatest volume loss in bvFTD and ALS-FTD, and ALS, respectively, and were associated with specific neuropeptide expression abnormalities.
NEUROIMAGE-CLINICAL
(2023)
Article
Substance Abuse
Rachel Visontay, Louise Mewton, Matthew Sunderland, Steven Bell, Annie Britton, Bridie Osman, Hayley North, Nisha Mathew, Tim Slade
Summary: Through comprehensive multiverse and vibration of effects analyses, it was found that moderate alcohol consumption is associated with reduced inflammation. The robustness of this association to common variations in research parameters has wide-reaching implications for understanding disease aetiology and public health policy.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Clinical Neurology
Yue Yang, Dominic Rowe, Heather McCann, Claire E. Shepherd, Jillian J. Kril, Matthew C. Kiernan, Glenda M. Halliday, Rachel H. Tan
Summary: This study compared the pathology of ALS patients who received CuATSM and riluzole with those who only received riluzole, and found no significant difference in neuron density or TDP-43 burden. However, CuATSM treatment led to the presence of p62-immunoreactive astrocytes in the motor cortex and reduced Iba1 density in the spinal cord. There was no significant difference in astrocytic activity and SOD1 immunoreactivity with CuATSM treatment.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Kreepa G. Kooblall, Mark Stevenson, Michelle Stewart, Lachlan Harris, Oressia Zalucki, Hannah Dewhurst, Natalie Butterfield, Houfu Leng, Tertius A. Hough, Da Ma, Bernard Siow, Paul Potter, Roger D. Cox, Stephen D. M. Brown, Nicole Horwood, Benjamin Wright, Helen Lockstone, David Buck, Tonia L. Vincent, Fadil M. Hannan, J. H. Duncan Bassett, Graham R. Williams, Kate E. Lines, Michael Piper, Sara Wells, Lydia Teboul, Raoul C. Hennekam, Rajesh V. Thakker
Summary: The NFIX gene is associated with two allelic disorders, MAL and MSS, which are characterized by developmental, skeletal, and neural abnormalities. Mutations in exon 2 lead to NFIX haploinsufficiency in MAL, while mutations in exons 6-10 result in the production of dominant-negative mutant NFIX proteins in MSS. In this study, mouse models with exon 7 deletions were generated to investigate the in vivo effects of MSS-associated NFIX mutations. The Nfix(Del2/Del2) mice exhibited developmental abnormalities in skeletal and neural tissues, providing a model for studying the consequences of NFIX mutants that escape nonsense-mediated decay in MSS.
Letter
Clinical Neurology
Jordan Carroll, Heather Mccann, Glenda M. Halliday, John B. Kwok, Carol Dobson-Stone, Claire E. Shepherd
Review
Cell Biology
Benjamin Mitchell, Stefan Thor, Michael Piper
Summary: This article summarizes the diverse roles of SETD2 in mammalian cellular functions and development, with a particular focus on the central nervous system (CNS). The consequences of SETD2 variants in human disease are also discussed, along with future directions for understanding essential cellular functions of SETD2.
JOURNAL OF CELL SCIENCE
(2023)
Article
Clinical Neurology
Monica Pinkerton, Guinevere Lourenco, Maria Torres Pacheco, Glenda M. Halliday, Matthew C. Kiernan, Rachel H. Tan
Summary: This study aimed to assess the pathology of p62 in sporadic ALS patients and determine its association with disease pathology. The results identified more cytoplasmic p62 aggregates in patients with a shorter disease duration. The findings support further research on p62 as a potential prognostic biomarker in ALS.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Letter
Clinical Neurology
Claire E. Shepherd, Simon J. G. Lewis, Stephen Tisch, Heather McCann, Ben Jonker, Glenda M. Halliday
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Andrew J. Affleck, Perminder S. Sachdev, Glenda M. Halliday
Summary: This study examines the impact of antihypertensive medication use on the severity of neuropathological cerebrovascular disease in older individuals. The results suggest that antihypertensive medication use is associated with less severe white matter small vessel disease. However, there is no significant relationship between medication use and infarction, lacunes, or cerebral amyloid angiopathy. Antihypertensive medication use reduces white matter rarefaction and Aβ propagation through the brain, specifically in individuals with moderate to severe white matter small vessel disease.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Biochemical Research Methods
Brad Balderson, Michael Piper, Stefan Thor, Mikael Boden
Summary: Cytocipher is a bioinformatics method and software package that statistically determines significant clusters, overcoming the challenges of manual curation in single-cell RNA-seq analysis. Its application to various datasets revealed previously unidentified cell types and demonstrated high performance on large-scale data.
Letter
Clinical Neurology
Matthew C. Kiernan, Glenda M. Halliday, Dominic B. Rowe, Rachel H. Tan
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)