Article
Cell Biology
Yueying Zhou, Iman M. A. Al-Naggar, Po-Jung Chen, Nathan S. Gasek, Ke Wang, Shivam Mehta, George A. Kuchel, Sumit Yadav, Ming Xu
Summary: Aging is a major risk factor for joint disorders, and TMJ degeneration in older age can significantly impact quality of life without effective treatment options. This study demonstrates that pharmaceutical intervention targeting cellular senescence can alleviate age-related TMJ degeneration, suggesting potential for future clinical trials with senolytics proven to be relatively safe in human studies.
Article
Plant Sciences
Pan Shen, Weiji Lin, Xin Ba, Yao Huang, Zhe Chen, Liang Han, Kai Qin, Ying Huang, Shenghao Tu
Summary: Herba taxilli, composed of Taxillus chinensis, is used in traditional Chinese medicine to treat inflammation and arthritis. Quercetin, a key component, shows antiarthritic effects and may act through SIRT1 to target mitochondrial biogenesis in rheumatoid arthritis treatment. Further research is needed to fully understand the mechanisms involved.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cajsa Aranas, Jesper Vestlund, Sarah Witley, Christian E. Edvardsson, Aimilia Lydia Kalafateli, Elisabet Jerlhag
Summary: The study shows that the amylinergic pathway regulates certain nicotine-induced behaviors but does not affect nicotine-induced reward acquisition and expression. Additionally, the results demonstrate that sCT blocks nicotine's stimulatory effects and dopamine release, while preventing its impact on locomotor sensitization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Hung Chuang, Yi-Chin Lin, Jung Yang, Shu-Ting Chan, Shu-Lan Yeh
Summary: The present study investigated the effects of quercetin on cisplatin-induced myelosuppression and found that quercetin could attenuate myelosuppression by regulating hematopoietic growth factors and inhibitory factors.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biology
Deepika Raman, Charlotte Chene, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Veronique Clement, Frederic Batteux, Shazib Pervaiz
Summary: Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). A pilot study on a murine model of sclerodermatous cGVHD showed that treatment with the senolytic combination of dasatinib and quercetin (DQ) significantly improved physical and tissue-specific features associated with cGVHD pathogenesis. The study suggests the involvement of senescent cells in cGVHD and highlights the potential therapeutic strategy of using DQ.
Article
Nutrition & Dietetics
Steven Oei, Courtney L. Millar, Thuy Nga Nguyen Lily, Kenneth J. Mukamal, Douglas P. Kiel, Lewis A. Lipsitz, Marian T. Hannan, Shivani Sahni
Summary: This study found that total flavonoid intake was not associated with frailty onset in adults, but higher intake of flavonols, particularly quercetin, was associated with lower odds of frailty onset. These results highlight the importance of assessing specific subclasses of flavonoids and the potential of dietary flavonols and quercetin as a strategy to prevent frailty development.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Saori Ohmae, Sota Akazawa, Toshio Takahashi, Takayuki Izumo, Tomohiro Rogi, Masaaki Nakai
Summary: This study aimed to investigate the effects of quercetin on adipogenesis and fibrosis in human skeletal muscle. The results showed that quercetin can reduce lipid accumulation and inhibit the expression of adipogenic genes, as well as decrease the expression of fibrogenic genes by inhibiting a specific signaling pathway. Quercetin can be taken through diet or dietary supplements to prevent or treat muscle quality loss.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mengwei Zhang, Xin Tang, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Wei Chen, Shumao Cui
Summary: Urolithin A (Uro-A) has dose-dependent anti-aging effects in the colon, with a minimum effective dose of 3.0 mg kg(-1) day(-1). Uro-A improves grip strength and discrimination index, inhibits oxidative stress, muscle atrophy, and neuronal apoptosis, and provides protection for motor and cognitive functions by inhibiting NF-kappa B and mTOR targets.
Article
Biochemistry & Molecular Biology
Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia J. Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C. Petersen, Tamara Tchkonia, James L. Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi, Miranda E. Orr
Summary: This study examined the feasibility of orally delivered senolytic therapy for Alzheimer's disease. The results showed that the treatment had a positive impact on the safety, tolerability, and feasibility of patients, and the drugs were able to penetrate the central nervous system. Biomarker data provided insights into the senolytic effects, but further research with larger sample sizes and placebo-controlled studies is needed for confirmation.
Article
Geriatrics & Gerontology
Ting Fan, Yi Du, Mingwan Zhang, Austin Rui Zhu, Jianjun Zhang
Summary: This study demonstrates that D+Q can suppress LPS-induced HUVECs senescence by regulating RNA m6A, providing a new approach for the clinical treatment of age-related cardiovascular diseases.
Article
Endocrinology & Metabolism
Jie Sun, Yalan Pan, Xiaofeng Li, Lining Wang, Mengmin Liu, Pengcheng Tu, Chengjie Wu, Jirimutu Xiao, Qiuge Han, Weiwei Da, Yong Ma, Yang Guo
Summary: Quercetin has been found to play a role in disease prevention and health promotion, and recent studies have shown its potential in improving bone health. This study investigated the effects of quercetin on osteoporosis induced by androgen deprivation therapy in mice. The results showed that quercetin improved bone microstructure, bone strength, and muscle mass, and regulated glucose and lipid metabolism. The beneficial effects of quercetin may be attributed to its modulation of the GPCR6A/AMPK/mTOR signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Sunyoung Jeong, Sungryong Bae, Daeung Yu, Hyo-Seon Yang, Mi-Jin Yang, Jong-Hwa Lee, Jung-Heun Ha
Summary: In this study, the effects of quercetin on pulmonary inflammation and behavioral alteration induced by diesel exhaust particles (DEPs) were investigated. The results showed that dietary intervention with quercetin can attenuate DEP-induced pulmonary inflammation and behavioral abnormalities. Therefore, quercetin may be an effective means to prevent DEP-triggered pulmonary and behavioral abnormalities.
JOURNAL OF MEDICINAL FOOD
(2023)
Review
Geriatrics & Gerontology
Mario Nieto, Mina Konisgberg, Alejandro Silva-Palacios
Summary: Cellular senescence is associated with the development and progression of multiple age-related diseases, and the accumulation of senescent cells in the heart contributes to age-related pathologies. The use of senolytics has shown promise in eliminating these cells and providing potential therapies for cardiovascular disease.
Article
Biochemistry & Molecular Biology
Mohamed F. Dora, Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, Mohamed S. Elfeky, Yasser S. El-Sayed, Soad Al Jaouni, Ali H. El-Far
Summary: The study revealed that IONPs induced oxidative damage in the brains of rats, while quercetin supplementation could effectively protect the brain from oxidative injuries in a dose-dependent manner. It is recommended to supplement quercetin during IONP therapy to reduce potential health hazards.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
J. Lu, Q. Q. Guo, Y. Wang, Z. X. Zuo, Y. Y. Li
Summary: The study found that important factors influencing the changes in cognitive frailty stage include physiological, psychological, and social factors. Aside from the normal group, the other 5 groups were clustered into "stage of frailty change" and "stage of cognitive frailty change". Aging, early onset of chronic diseases, high pain intensity, and poor nutritional status may worsen the individual's evolution from the normal stage to the stage of frailty change, while increasing social activity may promote the individual's health.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
