Article
Cardiac & Cardiovascular Systems
Rashmin Hira, Jacquie R. Baker, Tanya Siddiqui, Shaun I. Ranada, Ateyeh Soroush, Kavithra Karalasingham, Hyeqa Ahmad, Vibhuti Mavai, Luciano Martin Ayala Valani, Sakina Ambreen, Kate M. Bourne, Matthew G. Lloyd, Carlos A. Morillo, Robert S. Sheldon, Satish R. Raj
Summary: The study found that COVID-19 patients with post-acute sequalae have cardiovascular autonomic abnormalities, mainly postural orthostatic tachycardia syndrome and initial orthostatic hypotension. The frequency of postural orthostatic tachycardia syndrome is higher in female patients, while the frequency of initial orthostatic hypotension is equal between male and female patients. Even nonhospitalized patients may experience long-term cardiovascular autonomic abnormalities.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Artur Fedorowski, Richard Sutton
Summary: The post-acute sequelae of COVID-19 pose significant challenges for patients, physicians, and the healthcare system. These sequelae are not dependent on the severity of the initial infection, often exhibit pronounced symptoms, and can even occur after vaccination. Many cases involve cardiovascular autonomic dysfunction, with 30% of individuals experiencing postural orthostatic tachycardia syndrome. The prognosis remains uncertain, and treatment options are still inadequate.
NATURE REVIEWS CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Adnan Ahmed, Naga Venkata K. Pothineni, Rishi Charate, Jalaj Garg, Mehmet Elbey, Carlo de Asmundis, Mark LaMeir, Ahmed Romeya, Poojita Shivamurthy, Brian Olshansky, Andrea Russo, Rakesh Gopinathannair, Dhanunjaya Lakkireddy
Summary: Inappropriate sinus tachycardia (IST) is a common clinical syndrome affecting young patients and causing distressing symptoms. The underlying mechanism of IST is not fully understood, but autonomic dysfunction is considered to be the central abnormality. Diagnosis of IST is exclusionary and management presents challenges. Advances in sinus node sparing ablation techniques have improved treatment outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Pediatrics
Diana Drogalis-Kim, Collin Kramer, Silvestre Duran
Summary: This study describes 9 pediatric patients who experienced persistent and severe dizziness for weeks to months after their acute SARS-CoV-2 infection. Some of these patients met the diagnostic criteria for postural orthostatic tachycardia syndrome (POTS) and experienced improvement with a combination of nonpharmacologic therapy and medication.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Clinical Neurology
Brent P. Goodman, Julie A. Khoury, Janis E. Blair, Marie F. Grill
Summary: This study reported a case series of dysautonomia associated with COVID-19 infection in 6 patients. While all patients presented typical symptoms like fatigue and activity intolerance, autonomic testing results varied, with postural tachycardia, orthostatic hypotension, and postural hypertension observed in different patients.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Cody R. Hou, Brian Olshansky, Daniel Cortez, Sue Duval, David G. Benditt
Summary: There is inconsistency in the definitions of inappropriate sinus tachycardia in current literature, and professional society consensus definitions have limited impact.
Review
Cardiac & Cardiovascular Systems
Muzaffar Ali, Abdul Qadir Haji, Asim Kichloo, Blair P. Grubb, Khalil Kanjwal
Summary: Inappropriate sinus tachycardia (IST) is characterized by a resting heart rate above 100 bpm and is more common in middle-aged women. The possible mechanisms of IST are diverse, and it is associated with various distressing symptoms. However, IST is not linked to tachycardia-related cardiomyopathy or increased major cardiovascular events.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Karan R. Chadda, Ellen E. Blakey, Christopher L. -H. Huang, Kamalan Jeevaratnam
Summary: While the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. Patients with long COVID, which refers to ongoing symptoms post-infection, may experience dysautonomia, particularly postural orthostatic tachycardia syndrome (POTS). The underlying mechanisms of these complications include hypovolaemia, neurotropism, inflammation, and autoimmunity. Limited treatment options are available for POTS and other long COVID symptoms, and future research should focus on elucidating the underlying mechanisms and developing targeted therapies. It is also important for healthcare professionals to be educated on recognizing complications and conditions arising from COVID-19, such as POTS, to enable prompt diagnosis and access to early treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Hadar Meringer, Saurabh Mehandru
Summary: The definition, frequency, and pathophysiology of gastrointestinal involvement in post-acute COVID-19 syndrome are not fully understood. This article discusses emerging evidence that supports immunological signatures and highlights the unique nature of the gastrointestinal tract in this syndrome.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Pathology
Felix Scholkmann, Christian-Albrecht May
Summary: According to the World Health Organization, there have been over 760 million confirmed COVID-19 cases worldwide and more than 13 billion COVID-19 vaccine doses administered as of April 2023. In addition to acute COVID-19, the infection with SARS-CoV-2 can also result in a post-acute COVID-19 syndrome (PACS). The article discusses the side effects of COVID-19 vaccines, proposes new terms (PCVS, ACVS, and PACVS) to refer to these side effects, and emphasizes the importance of distinguishing between acute and post-acute vaccine-related syndromes.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Infectious Diseases
Joan Bosco, Ruwanthi Titano
Summary: Dysautonomia as a consequence of COVID-19 infection is becoming more prevalent. This case report highlights a non-hospitalized patient with mild initial presentation but severe and debilitating dysautonomia symptoms. Further research on its pathophysiology and treatment is needed.
BMC INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Carla Marina Roman-Montes, Yesenia Flores-Soto, Guillermo Arturo Guaracha-Basanez, Karla Maria Tamez-Torres, Jose Sifuentes-Osornio, Ma. Fernanda Gonzalez-Lara, Alfredo Ponce de Leon
Summary: This study aimed to describe the prevalence, characteristics, and impact on the quality of life of post-COVID-19 syndrome (PCS) in hospitalized patients. Out of 246 patients, 187 (76%) met the definition of PCS. PCS had a prolonged duration and impaired quality of life. Neurological symptoms such as difficulty concentrating were the most frequent symptoms.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Alessio Simonetti, Evelina Bernardi, Delfina Janiri, Marianna Mazza, Silvia Montanari, Antonello Catinari, Beatrice Terenzi, Matteo Tosato, Vincenzo Galluzzo, Francesca Ciciarello, Francesco Landi, Gabriele Sani
Summary: Post-acute sequelae of COVID-19 include neuropsychiatric disorders, and there is a link between post-COVID-19 syndrome and suicidality. Individuals with persistent post-COVID-19 syndrome have a higher risk of suicide, accompanied by physical complaints, psychiatric history, and anxiety. Treatment for physical complaints and psychotherapy may reduce the risk of suicide.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Florian Desgranges, Eliana Tadini, Aline Munting, Jean Regina, Paraskevas Filippidis, Benjamin Viala, Eleftherios Karachalias, Veronique Suttels, David Haefliger, Eleftheria Kampouri, Mathias Van Singer, Jonathan Tschopp, Laurence Rochat Stettler, Simeon Schaad, Thomas Brahier, Olivier Hugli, Yolanda Mueller, Alexandre Gouveia, Onya Opota, Pierre-Nicolas Carron, Benoit Guery, Matthaios Papadimitriou-Olivgeris, Noemie Boillat-Blanco
Summary: More than half of outpatients with mild COVID-19 report persistent symptoms up to 10 months after the disease. Only four symptoms were found to be associated with COVID-19 status. Female gender and overweight/obesity were identified as predictors of persistent symptoms among COVID-positive patients.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Michele Senni, Andrea Barison, Giorgia Panichella, Claudio Passino, Antoni Bayes-Genis, Michele Emdin
Summary: HFpEF is a syndrome with multifaceted pathophysiology and clinical heterogeneity, which calls for personalized approaches in treatment. The recent discovery of SGLT2i therapy provides new perspectives on reducing the risk of death or hospitalization for patients with HFpEF.
HEART FAILURE REVIEWS
(2023)
Letter
Cardiac & Cardiovascular Systems
Miguel Lorenzo, Rafael de la Espriella, Ingrid Cardells, Joso Luis Gorriz, Antoni Bayes-Genis, Julio Nunez
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria Vilalta, German Cediel, Siamak Mohammadi, Helena Lopez, Dimitri Kalavrouziotis, Helena Resta, Eric Dumont, Pierre Voisine, Francois Philippon, Claudia Escabia, Andrea Borrellas, Alberto Alperi, Eduard Fernandez-Nofrerias, Xavier Carrillo, Vassili Panagides, Antoni Bayes-Genis, Josep Rodes-Cabau
Summary: This study evaluated the incidence, predictive factors, and prognostic value of new-onset persistent left bundle branch block (NOP-LBBB) in patients undergoing sutureless surgical aortic valve replacement (SU-SAVR). The results showed that NOP-LBBB occurred in approximately a quarter of the patients and was associated with a decrease in left ventricular ejection fraction (LVEF) and an increased risk of permanent pacemaker implantation (PPI).
Article
Cardiac & Cardiovascular Systems
Damia Pereferrer, Axel Sarrias, Raquel Adelino, Felipe Bisbal, Julia Aranyo, Nuria Vallejo, Roger Villuendas, Antoni Bayes-Genis, Victor Bazan
Summary: This study aimed to determine the prevalence of E/a superposition in dual-chamber pacemaker patients and investigate the impact of AVI shortening on clinical, echocardiographic, and biological measures. The results showed that approximately half of the patients experienced E/a superposition, which was associated with reduced left ventricular function and increased myocardial injury biomarkers. Shortening the AVI had a modest but significant effect on functional capacity and quality of life.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Immunology
Nuria Climent, Juan Ambrosioni, Tania Gonzalez, Cristina Xufre, Maria Casadella, Marc Noguera-Julian, Roger Paredes, Montserrat Plana, Judith Grau-Exposito, Josep Mallolas, Jose Alcami, Sonsoles Sanchez-Palomino, Jose M. Miro
Summary: This study reports a case of a highly controlled HIV infection individual who maintained undetectable viral loads for 15 years after stopping antiretroviral therapy. The researchers found that the high activity of NK cells and CD8 T cells were associated with the control of viral replication.
Article
Immunology
Maria Ubals, Eloy Jose Tarin-Vicente, Xenia Oller, Adria Mendoza, Andrea Alemany, Agueda Hernandez-Rodriguez, Cristina Casan, Angel Rivero, Pep Coll, Jose Miguel Cabrera, Marti Vall, Manuel Agud-Dios, Elena Gil-Cruz, Alexia Paris de Leon, Aida Ramirez, Maria Dolores Folgueira, Maria Angeles Melendez, Vira Buhiichyk, Cristina Galvan-Casas, Roger Paredes, Nuria Prat, Maria-Rosa Sala Farre, Josep Maria Bonet-Simo, Pablo L. Ortiz-Romero, Bonaventura Clotet, Pere-Joan Cardona, Ignacio Blanco, Michael Marks, Clara Suner, Oriol Mitja, Movie Group
Summary: The accuracy of self-collected samples for diagnosing monkeypox was evaluated in a study of 50 individuals. Results showed that self-sampling performed similarly to physician-collected samples, suggesting it as a reliable strategy for diagnosis.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stefan D. Anker, Muhammad Shariq Usman, Markus S. Anker, Javed Butler, Michael Boehm, William T. Abraham, Marianna Adamo, Vijay K. Chopra, Mariantonietta Cicoira, Francesco Cosentino, Gerasimos Filippatos, Ewa A. Jankowska, Lars H. Lund, Brenda Moura, Wilfried Mullens, Burkert Pieske, Piotr Ponikowski, Jose R. Gonzalez-Juanatey, Amina Rakisheva, Gianluigi Savarese, Petar Seferovic, John R. Teerlink, Carsten Tschoepe, Maurizio Volterrani, Stephan von Haehling, Jian Zhang, Yuhui Zhang, Johann Bauersachs, Ulf Landmesser, Shelley Zieroth, Konstantinos Tsioufis, Antoni Bayes-Genis, Ovidiu Chioncel, Felicita Andreotti, Enrico Agabiti-Rosei, Jose L. Merino, Marco Metra, Andrew J. S. Coats, Giuseppe M. C. Rosano
Summary: HFpEF is a highly heterogeneous clinical syndrome influenced by many comorbidities in its development and progression. Left ventricular diastolic dysfunction may result from various cardiovascular, metabolic, pulmonary, renal, and geriatric conditions. Therefore, individualized treatment tailored to each patient's clinical profile may be the most effective approach to improve clinical outcomes. In this joint position paper, the Heart Failure Association of the European Society of Cardiology, the European Heart Rhythm Association, and the European Hypertension Society have developed an algorithm to identify the most common HFpEF phenotypes and recommend evidence-based treatment strategies for each, considering the complexities of multiple comorbidities and polypharmacy.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico D'Amario, David Meerkin, Attilio Restivo, Hueseyin Ince, Horst Sievert, Andrea Wiese, Ulrich Schaefer, Carlo Trani, Antoni Bayes-Genis, Francisco I. Leyva, Zachary Whinnett, Carlo Di Mario, Michael Jonas, Habib J. Manhal, Ignacio Amat-Santos, Maria Del Trigo, Tuvia Ben Gal, Binyamin Ben Avraham, Tal Hasin, Sebastian Feickert, Giuseppe D'Ancona, Omar Abdul-Jawad Altisent, Oran Koren, Oren T. Caspi, William Abraham, Filippo D. Crea, Stefan Anker, Ran Kornowski, Leor Perl
Summary: The study evaluated a novel left atrial pressure (LAP) monitoring system in heart failure patients and found that it was safe and provided a good correlation with invasive pulmonary capillary wedge pressure (PCWP). Initial evidence also suggests possible improvement in heart failure clinical symptoms.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Iolanda Lazaro, Josep Lupon, German Cediel, Aleix Sala-Vila, Antoni Bayes-Genis
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ricardo Rodriguez-Calvo, Minerva Granado-Casas, Alejandra Perez-Montes de Oca, Maria Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Josep Julve, Joana Rossell, Lluis Masana, Didac Mauricio, Josep Lupon, Antoni Bayes-Genis, Nuria Alonso
Summary: This study aimed to explore the prognostic value of cardiac-specific fatty acid binding proteins (FABP3) and adipose-tissue-specific fatty acid binding proteins (FABP4) in chronic heart failure (CHF) patients, with and without type 2 diabetes mellitus (T2D). It was found that the concentrations of FABP3 and FABP4 were associated with all-cause and cardiovascular mortality, particularly in patients with T2D. The study suggests that serum FABP3 and FABP4 concentrations can serve as independent predictors for the occurrence of all-cause and cardiovascular mortality in ambulatory CHF subjects with T2D.
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Josep Lupon, Pau Codina
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Petar M. Seferovic, Marija Polovina, Giuseppe Rosano, Biykem Bozkurt, Marco Metra, Stephane Heymans, Wilfried Mullens, Johann Bauersachs, Karen Sliwa, Rudolf A. de Boer, Dimitrios Farmakis, Thomas Thum, Iacopo Olivotto, Claudio Rapezzi, Ales Linhart, Domenico Corrado, Carsten Tschope, Ivan Milinkovic, Antoni Bayes Genis, Gerasimos Filippatos, Andre Keren, Milika Asanin, Gordana Krljanac, Ruzica Maksimovic, Hadi Skouri, Tuvia Ben Gal, Brenda Moura, Maurizio Volterrani, Magdy Abdelhamid, Yuri Lopatin, Ovidiu Chioncel, Andrew J. S. Coats
Summary: Cardiomyopathies play a significant role in cardiovascular morbidity and mortality. Progress has been made in understanding the genetic background and pathophysiological mechanisms, leading to improved diagnostic and risk stratification approaches. Targeted therapies and standard care have the potential to improve outcomes in various types of cardiomyopathies.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Rafael de la Espriella, Julio Nunez
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pau Codina, David Dobarro, Javier de Juan-Baguda, Fernando De Frutos, Josep Lupon, Antoni Bayes-Genis, Jose Gonzalez-Costello, Spanish LEVO D Registry Collaborators
Summary: This study aimed to evaluate the mortality prediction performance of the MAGGIC-HF risk score and the BCN-Bio-HF model in advanced HF patients receiving levosimendan as destination therapy. The results showed suboptimal discrimination and calibration of these two risk scores, with an underestimation of risk. Specific risk scores for advanced HF are needed.
Article
Cardiac & Cardiovascular Systems
Julia Aranyo, Daina Martinez-Falguera, Victor Bazan, Edgar Fadeuilhe, Albert Teis, Axel Sarrias, Oriol Rodriguez-Leor, Carolina Curiel, Roger Villuendas, Antoni Bayes-Genis, Carolina Galvez-Monton, Felipe Bisbal
Summary: This study aimed to test the application of local impedance (LI)-based mapping in predicting critical components of ventricular tachycardia (VT) after myocardial infarction (MI). The results showed that specific LI patterns were associated with VT inducibility and colocalized with the VT isthmus, thus representing a potential new target for ablation in substrate-based procedures.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
