Journal
SCIENTIFIC REPORTS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-06189-5
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Funding
- Amore-Pacific Co. R&D Center (Applied Technology and Research Division)
- Basic Science Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2019R1C1C1009360]
- National Research Foundation of Korea - Korea government (MSIT) [NRF-2019R1A4A1024764]
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The study revealed significant differences in the skin microbiome between the younger and older age groups, particularly in terms of microbial diversity and specific microbial biomarkers.
We examined differences in the skin microbiome of two separate age groups to find key microbial and skin physiological indicators associated with aging. We recruited healthy Korean women 19-28 years old (Y-group) and 60-63 years old (O-group) and evaluated their cheek and forehead skin microbiome, including bacteria and fungi. The microbiome was significantly different by age group, with bacterial and fungal communities displaying higher alpha-diversity in the O-group than in the Y-group. We identified amplicon sequence variants affiliated with Cutibacterium and Lactobacillus and fungi Malassezia restricta as microbial biomarkers showing significant differences between the Y and O-group. There are more microbial communities and metabolic processes related to skin health in the Y-group than in the O-group, and there are more microbial interactions to increase the stability of the network structure of the skin. Skin physical metadata, including transepidermal water loss and sebum content, differed by two age groups. The crucial skin microbes, skin physical parameters, and microbial network found through this research will be useful key indicators in associating skin aging and skin microbiome research.
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