Understanding the Functional Activity of Polyphenols Using Omics-Based Approaches

Plant polyphenols are the main category of natural active substances, and are distributed widely in vegetables, fruits, and plant-based processed foods. Polyphenols have a beneficial performance in preventing diseases and maintaining body health. However, its action mechanism has not been well understood. Foodomics is a novel method to sequence and widely used in nutrition, combining genomics, proteomics, transcriptomics, microbiome, and metabolomics. Based on multi-omics technologies, foodomics provides abundant data to study functional activities of polyphenols. In this paper, physiological functions of various polyphenols based on foodomics and microbiome was discussed, especially the anti-inflammatory and anti-tumor activities and gut microbe regulation. In conclusion, omics (including microbiomics) is a useful approach to explore the bioactive activities of polyphenols in the nutrition and health of human and animals.

Automated summary

Plant polyphenols, the main category of natural active substances, have beneficial effects in preventing diseases and maintaining body health. Foodomics, combining various omics technologies, provides abundant data to study the functional activities of polyphenols. Polyphenols exhibit anti-inflammatory, anti-tumor activities, and regulate gut microbiota.