Journal
NUTRIENTS
Volume 14, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/nu14030430
Keywords
dementia; feasibility trial; randomised controlled trial; dietary nitrate; reduced salt
Categories
Funding
- National Institute for Health Research (NIHR) GHR Group [16/137/62]
- NIHR Global Health Research Group on Dementia Prevention and Enhanced Care (DePEC), Newcastle University, UK
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The DePEC-Nutrition trial aimed to assess the feasibility and acceptability of a complex dietary and behavioural intervention for Malaysian middle-aged and older adults with elevated blood pressure. The study recruited 74 participants and achieved a 73% retention rate over 10 months. All intervention strategies, including group counselling, were found to be feasible and acceptable.
The DePEC-Nutrition trial is a complex dietary and behavioural intervention of salt intake reduction combined with increased high-nitrate vegetable consumption among Malaysian middle-aged and older adults with elevated blood pressure. This study aimed to assess the feasibility and acceptability of the trial. Participants were recruited from the South East Asia Community Observatory (SEACO) database and randomised into one of four groups: (1) low salt; (2) high-nitrate vegetable; (3) combined high-nitrate vegetable and low salt; and (4) control. The intervention included a combination of group counselling sessions, information booklets, reinforcement videos and text messages to modify dietary behaviour. The primary outcomes evaluated were the measures of feasibility and acceptability of (1) recruitment, follow-up attendance and retention; (2) data collection procedures and clinical outcome measures; and (3) individual and combined multi-modal dietary interventions. A total of 74 participants were recruited, and the 10-month retention rate was 73%. Data collection procedures were acceptable with minimal missing data. All intervention strategies were feasible and acceptable, with group counselling being the most acceptable strategy. This study provides important insights into improving the screening process of participants, facilitating their access to the research facilities and refining the measurement protocols and dietary recommendations, which are instrumental in formulating the design of a full-scale definitive DePEC-Nutrition trial.
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