Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging

Antisense technology: an overview and prospectus

(2021) Stanley T. Crooke et al.   NATURE REVIEWS DRUG DISCOVERY

Tracking the formation and degradation of fatty-acid-accumulated mitochondria using label-free chemical imaging

(2021) Chi Zhang et al.   Scientific Reports

Non-invasive monitoring of pharmacodynamics during the skin wound healing process using multimodal optical microscopy

(2020) Jose Rico-Jimenez et al.   BMJ Open Diabetes Research & Care

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

(2020) Alexandre J. Debacker et al.   MOLECULAR THERAPY

Macrophage phagocytosis assay with reconstituted target particles

(2020) Aaron M. Joffe et al.   Nature Protocols

Dynamic Signatures of Lipid Droplets as New Markers to Quantify Cellular Metabolic Changes

(2020) Chi Zhang et al.   ANALYTICAL CHEMISTRY

Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle

(2019) Shouta Miyatake et al.   Molecular Therapy-Nucleic Acids

Selective tissue targeting of synthetic nucleic acid drugs

(2019) Punit P. Seth et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic Antisense Oligonucleotides Are Coming of Age

(2019) C. Frank Bennett   Annual Review of Medicine

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Simultaneous label-free autofluorescence and multi-harmonic imaging reveals in vivo structural and metabolic changes in murine skin

(2019) Jang Hyuk Lee et al.   Biomedical Optics Express

Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver

(2018) Colton M. Miller et al.   Nucleic Acid Therapeutics

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy

(2017) Sixian You et al.   JOURNAL OF BIOMEDICAL OPTICS

Capacity limits of asialoglycoprotein receptor-mediated liver targeting

(2017) Charlotte Bon et al.   mAbs

Cellular uptake and trafficking of antisense oligonucleotides

(2017) Stanley T Crooke et al.   NATURE BIOTECHNOLOGY

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

(2017) Michael Tanowitz et al.   NUCLEIC ACIDS RESEARCH

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis

(2017) Nuria Andreu et al.   Scientific Reports

The Medicinal Chemistry of Therapeutic Oligonucleotides

(2016) W. Brad Wan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

(2016) Colton M. Miller et al.   NUCLEIC ACIDS RESEARCH

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

Asialoglycoprotein receptor mediated hepatocyte targeting — Strategies and applications

(2015) Anisha A. D'Souza et al.   JOURNAL OF CONTROLLED RELEASE

Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

(2015) J.-X. Cheng et al.   SCIENCE

Scientific and Regulatory Policy Committee Points-to-consider Paper*

(2015) Jeffery A. Engelhardt et al.   TOXICOLOGIC PATHOLOGY

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Antisense Oligonucleotide Therapies

(2014) Kendall S. Frazier   TOXICOLOGIC PATHOLOGY

Molecular imaging of live cells by Raman microscopy

(2013) Almar F Palonpon et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

(2012) Kendall S. Frazier et al.   TOXICOLOGIC PATHOLOGY

Highly specific label-free molecular imaging with spectrally tailored excitation-stimulated Raman scattering (STE-SRS) microscopy

(2011) Christian W. Freudiger et al.   Nature Photonics

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy

(2008) Christian W. Freudiger et al.   SCIENCE