Article
Medicine, Research & Experimental
Mitsuru Esaki, Eikichi Ihara, Noriaki Manabe, Noriyuki Kawami, Katsuhiko Iwakiri, Junichi Akiyama, Shiko Kuribayashi, Toshio Uraoka, Haruei Ogino, Takatoshi Chinen, Akiko Misumi, Hiroko Watanabe, Maya Suzuki, Junji Kishimoto, Yoshihiro Ogawa
Summary: This study is the first prospective and randomized controlled trial to investigate the superiority of acotiamide over a placebo in the treatment of patients with EGJOO. The trial provides evidence that acotiamide can be used as a treatment for patients with EGJOO. Long-term outcomes cannot be assessed because this trial focuses on the short-term outcomes of acotiamide for the treatment of patients with EGJOO.
Article
Gastroenterology & Hepatology
Albert J. Bredenoord, Arash Babaei, Dustin Carlson, Taher Omari, Jun Akiyama, Rena Yadlapati, John E. Pandolfino, Joel Richter, Ronnie Fass
Summary: EGJOO is defined as an elevated IRP and IBP during wet swallows and persistently elevated IRP in the upright position according to CCv4. A conclusive diagnosis requires a manometric diagnosis of EGJOO and associated symptoms supported by additional investigations, with history and endoscopic evaluation being crucial for excluding secondary causes. Proposed changes in CC4.0 aim to improve specificity of diagnosis and reduce clinically irrelevant diagnoses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Yue-Yuan Li, Wen-Ting Lu, Jian-Xiang Liu, Li-Hong Wu, Meng Chen, Hong-Mei Jiao
Summary: This study aimed to evaluate the esophageal motility characteristics of patients with EGJOO and identify valuable parameters for confirming the diagnosis. The results showed that based on CCv4.0, patients with EGJOO had more severe esophagogastric junction dysfunction and were implicated in the proximal esophagus. Additionally, several parameters were supportive for confirming the diagnosis of EGJOO.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexander T. Reddy, Rahul A. Shimpi, Alice Parish, Donna Niedzwiecki, David A. Leiman
Summary: In patients with non-mechanical EGJOO, lower total heartburn and regurgitation scores, as well as FLIP measurements of LES diameter, are associated with definitely low distensibility index (DI). These findings can aid in predicting DI and provide useful adjunctive data for evaluating outflow obstruction in patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Medicine, General & Internal
Yorinari Ochiai, Daisuke Kikuchi, Kosuke Nomura, Takayuki Okamura, Junnosuke Hayasaka, Yugo Suzuki, Nobuhiro Dan, Yutaka Mitsunaga, Masami Tanaka, Hiroyuki Odagiri, Satoshi Yamashita, Akira Matsui, Shu Hoteya
Summary: In patients with functional EGJOO, some may present with an esophageal rosette sign (ERS), a characteristic endoscopic finding of achalasia.
Article
Gastroenterology & Hepatology
Mate Csucska, Takahiro Masuda, Ross M. Bremner, Sumeet K. Mittal
Summary: The study aimed to compare preperistaltic distal esophageal pressure in patients with EGJOO with and without dysphagia. Patients with severe dysphagia had significantly higher median preperistaltic pressures in the distal esophagus, which showed better sensitivity and specificity for dysphagia than integral relaxation pressure. Inclusion of preperistaltic pressure in the diagnostic criteria for EGJOO may enhance the clinical relevance of manometric classification.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Joseph R. Triggs, Shivani U. Thanawala, Nitin K. Ahuja, Gary W. Falk, Alain J. Benitez, Kristle L. Lynch
Summary: This study found that in patients with abnormal EGJ-DI, treatment with botulinum toxin can significantly improve symptoms. Abnormal EGJ-DI measurements were significantly associated with other parameters used previously to determine clinically relevant EGJOO.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Medicine, General & Internal
Yan Wang, Ting Yu, Feng Zhu, Ying Xu, Yun Bao, Ling Zhang, Lin Lin, Yurong Tang
Summary: This study compared the clinical characteristics and outcomes of esophagogastric junction outflow obstruction (EGJOO) and achalasia cardia (AC) through a 4-year follow-up. It was found that EGJOO patients were older, had shorter disease duration, lower Eckardt scores, and were more likely to have concurrent adenocarcinoma of the esophagogastric junction and autoimmune disease compared to AC patients.
Article
Gastroenterology & Hepatology
Daniela Jodorkovsky, Danny Wong, Ryan Din, Daniel R. Sikavi, Darren J. H. Lee, Jennifer X. Cai, Wai-Kit Lo, Walter W. Chan
Summary: This study found that EGJOO patients with abnormal EBM are more likely to experience esophageal symptoms, indicating that abnormal EBM may impact the clinical presentation of EGJOO.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Andrew R. Leopold, Aria Jalalian, Parth Thaker, Jennifer Wellington, Marianna Papademetriou, Guofeng Xie
Summary: Esophagogastric junction outflow obstruction (EGJOO) is a esophageal motility disorder characterized by a lack of relaxation of the esophagogastric junction. The coexistence of EGJOO with hypercontractile esophagus and distal esophageal spasm can be classified as a major mixed motility disorder (MMMD), and EGJOO with normal peristalsis or minor disorder of peristalsis can be classified as isolated EGJOO (IEGJOO). High-resolution manometry (HRM) can detect differences between MMMD and IEGJOO, and patients with MMMD have a greater short-term prognosis and response to endoscopic therapy.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Songfeng Chen, Mengya Liang, Niandi Tan, Mengyu Zhang, Yuqing Lin, Peixian Cao, Qianjun Zhuang, Yinglian Xiao
Summary: This retrospective study described the clinical characteristics of 138 patients with esophagogastric junction outflow obstruction (EGJOO) who underwent high-resolution manometry examination in our hospital from 2013 to 2019. The results showed that only 2.9% of patients had persistent dysphagia, while 81.8% of patients experienced symptom resolution during follow-up. High upright IRP (>9.05 mmHg) was associated with persistent dysphagia and may require further evaluation and aggressive management.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Inanc S. Sarici, Sven Eriksson, Mohamad Rassoul Abu-Nuwar, Jacob Kuzy, Margaret Gardner, Ping Zheng, Blair Jobe, Shahin Ayazi
Summary: This study compared the outcomes and impact on esophageal physiology in patients undergoing Heller myotomy with Dor fundoplication (HMD) or per oral endoscopic myotomy (POEM) for primary esophagogastric junction outflow obstruction (EGJOO). The results showed that both HMD and POEM were equally effective at relieving EGJOO symptoms, but POEM caused worse reflux and near complete loss of esophageal body function.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Scott Morton, Andrew D. Grubic, Shahin Ayazi, Satish C. Muluk, Hiran C. Fernando, Blair A. Jobe
Summary: Vascular impingement causing dysphagia is rare, with aortic arch anomalies or azygous vein aneurysm being potential causes. HRIM is crucial for diagnosis. The close anatomical relationship between the azygous vein and esophagus can lead to esophageal obstruction in pathological conditions.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, General & Internal
Yu-Ling Pan, Pei-Shan Wu, Bing-Wei Ye, Chung-Pin Li, I-Cheng Lee, Kuei-Chuan Lee, Yi-Hsiang Huang, Ming-Chih Hou
Summary: This study investigated the outcomes of metallic stent placement in malignant EGJ obstruction, showing that poststent radiotherapy significantly prolonged survival and stent patency time, with no differences found between patients receiving different types of stents.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Kazuhide Matsumoto, Nao Fujimori, Yoshitaka Hata, Yosuke Minoda, Masatoshi Murakami, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Eikichi Ihara, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa
Summary: This study investigated the clinical characteristics of ampullary neuroendocrine neoplasms (NENs) and found distinct differences between ampullary NENs and pancreatic NENs, such as higher incidences of NEC and cholangitis in ampullary NENs. Furthermore, the study discovered identifiable distinctions between ampullary NETs and NECs through endoscopic findings.
DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa
Summary: This study investigated the region-specific role of the M-3 receptor in gastrointestinal motility using a novel positive allosteric modulator (PAM-369). The results showed that PAM-369 selectively potentiated the M-3 receptor without agonistic or antagonistic activity and increased small intestinal transit in mice. However, it had no effect on colonic transit. This study provides the first direct evidence of the different functional roles of the M-3 receptor between the small intestine and colon.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Shohei Hamada, Eikichi Ihara, Chikako Yoshitake, Taisuke Inada, Hiroki Fukuya, Akito Ohkubo, Naru Tomoeda, Yoichiro Iboshi, Yorinobu Sumida, Daisuke Yoshimura, Makoto Nakamuta, Naohiko Harada
Summary: Endoscopic submucosal dissection (ESD) is a method used to treat early epithelial tumors of the gastrointestinal tract, but delayed perforation is a problematic complication. To address this issue, researchers have developed a simple and promising closure technique.
DIGESTIVE ENDOSCOPY
(2023)
Article
Surgery
Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa
Summary: Mucosal incision-assisted biopsy (MIAB) is a safe procedure with minimal impact on postoperative prognosis for sampling gastric subepithelial lesions (SELs). MIAB releases some tumor cells after damaging the SEL's pseudocapsule, but it does not significantly affect the 5-year disease-free survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Ryoji Ichijima, Hisatomo Ikehara, Yorinobu Sumida, Taisuke Inada, Daiki Nemoto, Yuki Nakajima, Takeyoshi Minagawa, Tetsuya Sumiyoshi, Kazuya Inoki, Naohisa Yoshida, Ken Inoue, Masakatsu Fukuzawa, Yosuke Minoda, Koshiro Tsutsumi, Mitsuru Esaki, Takuji Gotoda
Summary: A multicenter randomized trial found that the traction method did not significantly reduce the procedure time of colorectal endoscopic submucosal dissection (ESD). However, it may be useful in cases with a large tumor diameter or when performed by nonexpert operators.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Mitsuru Esaki, Masao Yoshida, Kohei Takizawa, Akifumi Notsu, Satoru Nonaka, Satoki Shichijo, Sho Suzuki, Chiko Sato, Hiroyuki Komori, Takeyoshi Minagawa, Ichiro Oda, Noriya Uedo, Kingo Hirasawa, Kenshi Matsumoto, Tetsuya Sumiyoshi, Seiichiro Abe, Takuji Gotoda, Hiroyuki Ono
Summary: Our study compared the treatment outcomes of endoscopic submucosal dissection (ESD) with an insulated-tip knife (ESD-IT) and a needle-type knife (ESD-N) for large superficial esophageal neoplasms. The results showed similar procedural outcomes between the two groups, but the handover rate was higher in ESD-N and the injection volume was higher in ESD-IT. Sub-analyses revealed that traction-assisted ESD (TA-ESD) significantly reduced the handover rate for ESD-N and decreased the injection volume for ESD-IT.
DISEASES OF THE ESOPHAGUS
(2023)
Editorial Material
Gastroenterology & Hepatology
Akihisa Ohno, Nao Fujimori, Toshiya Abe, Masafumi Nakamura, Yoshihiro Ogawa
Editorial Material
Gastroenterology & Hepatology
Yusuke Suzuki, Takashi Osoegawa, Masaru Kubokawa, Mitsuru Esaki, Yosuke Minoda, Haruei Ogino, Eikichi Ihara
Article
Peripheral Vascular Disease
Shintaro Sakaguchi, Ryuji Okamoto, Chisa Inoue, Masaharu Akao, Kohei Kamemura, Isao Kurihara, Yoshiyu Takeda, Youichi Ohno, Nobuya Inagaki, Hiromi Rakugi, Takuyuki Katabami, Mika Tsuiki, Akiyo Tanabe, Kouichi Tamura, Satoshi Fujita, Yutaka Yano, Kaoru Dohi, Mitsuhide Naruse
Summary: This study investigated the factors associated with comorbid atrial fibrillation (AF) and cardiovascular events in patients with primary aldosteronism (PA), as well as the effect of PA treatment. The study found that age, sex, cardiothoracic ratio, and history of coronary artery disease and heart failure were associated with AF, and PA patients with AF had a higher frequency of cardiovascular events. After PA treatment, AF, in addition to age, duration of hypertension, body mass index, and chronic kidney disease, was an independent prognostic factor for cardiovascular events. The incidence of cardiovascular events was lower in PA patients with AF compared to AF patients without PA.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Hiroki Kaneko, Hironobu Umakoshi, Tazuru Fukumoto, Norio Wada, Takamasa Ichijo, Shohei Sakamoto, Tetsuhiro Watanabe, Yuki Ishihara, Tetsuya Tagami, Masatoshi Ogata, Norifusa Iwahashi, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The clinical practice guideline emphasizes the importance of confirmatory tests for primary aldosteronism in order to avoid unnecessary adrenal venous sampling for false-positive cases. However, the study found that a combination of multiple confirmatory tests did not yield better results than individual tests in predicting subtypes of primary aldosteronism.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa
Summary: This study aimed to compare the treatment outcomes of hybrid endoscopic submucosal dissection (H-ESD) and conventional endoscopic submucosal dissection (C-ESD) for small early gastric neoplasms (EGNs). The results showed that H-ESD had significantly shorter procedure time than C-ESD, with comparable curability and safety. Therefore, H-ESD could be a good option for the endoscopic treatment of small EGNs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Taisuke Inada, Mitsuru Esaki, Yosuke Minoda
DIGESTIVE ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Kazuo Shiotsuki, Yorinobu Sumida, Mitsuru Esaki, Yosuke Minoda, Shin-ichiro Fukuda, Eikichi Ihara, Hirotada Akiho
Editorial Material
Gastroenterology & Hepatology
Yosuke Minoda, Nao Fujimori, Mitsuru Esaki, Shuzaburo Nagatomo, Yasuhiro Komori, Keijiro Ueda, Eikichi Ihara
