Local Electric Field Modulated Reactivity of Pseudomonas aeruginosa Acid Phosphatase for Enhancing Phosphorylation of l-Ascorbic Acid

Electrostatically Tuning the Photodissociation of the Irgacure 2959 Photoinitiator in the Gas Phase by Cation Binding

(2021) Samuel J. P. Marlton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses

(2021) Nemanja Milisavljevic et al.   ACS Infectious Diseases

Electric field–catalyzed single-molecule Diels-Alder reaction dynamics

(2021) Chen Yang et al.   Science Advances

Efficient Acylation of Sugars and Oligosaccharides in Aqueous Environment Using Engineered Acyltransferases

(2021) Simon P. Godehard et al.   ACS Catalysis

Altering the Phosphorylation Position of Pyrophosphate-Dependent myo-Inositol-1-Kinase Based on Its Crystal Structure

(2021) Ryo Tashiro et al.   ACS Chemical Biology

Desymmetrization of Diols by Phosphorylation with a Titanium-BINOLate Catalyst

(2021) Erik T. Ouellette et al.   JOURNAL OF ORGANIC CHEMISTRY

Local Electric Fields As a Natural Switch of Heme-Iron Protein Reactivity

(2021) Daniel Bím et al.   ACS Catalysis

Phosphorus-Based Catalysis

(2021) Changmin Xie et al.   ACS Central Science

Engineering Fatty Acid Photodecarboxylase to Enable Highly Selective Decarboxylation of trans Fatty Acids

(2021) Danyang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular Condensates

(2021) Zhenkun Na et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electric Fields in Catalysis: From Enzymes to Molecular Catalysts

(2021) Nadia G. Léonard et al.   ACS Catalysis

Oriented (local) Electric Fields Drive the Millionfold Enhancement of the H-Abstraction Catalysis Observed for Synthetic Metalloenzyme Analogues

(2020) Thijs Stuyver et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of Two Polyphosphate Kinase 2 Enzymes Used for ATP Synthesis

(2020) Xing Zhang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Preparative‐Scale Enzymatic Synthesis of rac ‐Glycerol‐1‐phosphate from Crude Glycerol Using Acid Phosphatases and Phosphate

(2020) Gábor Tasnádi et al.   ChemSusChem

Oriented External Electric Fields and Ionic Additives Elicit Catalysis and Mechanistic Crossover in Oxidative Addition Reactions

(2020) Jyothish Joy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Influence of Cell Culture Density on the Cytotoxicity of Adipose-Derived Stem Cells Induced by L-Ascorbic Acid-2-Phosphate

(2020) Yuan-Kun Wu et al.   Scientific Reports

Catalytic Chemoselective O-Phosphorylation of Alcohols

(2020) K. Domon et al.   ACS Central Science

Solvent Organization and Rate Regulation of a Menshutkin Reaction by Oriented External Electric Fields are Revealed by Combined MD and QM/MM Calculations

(2020) Kshatresh Dutta Dubey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphorylation Organocatalysts Highly Active by Design

(2020) Amit Fallek et al.   ORGANIC LETTERS

Structural study of l-ascorbic acid 2-phosphate magnesium, a raw material in cell and tissue therapy

(2020) Xiaolong Xu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Electric-Field Mediated Chemistry: Uncovering and Exploiting the Potential of (Oriented) Electric Fields to Exert Chemical Catalysis and Reaction Control

(2020) Sason Shaik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Engineering for Enhanced Acyltransferase Activity, Substrate Scope, and Selectivity of the Mycobacterium smegmatis Acyltransferase MsAcT

(2020) Simon P. Godehard et al.   ACS Catalysis

Enzymatic regeneration and conservation of ATP: challenges and opportunities

(2020) Hongge Chen et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Key advances in biocatalytic phosphorylations in the last two decades: Biocatalytic syntheses in vitro and biotransformations in vivo (in humans)

(2020) Roland Wohlgemuth   Biotechnology Journal

External Electric Fields Interrupt the Concerted Cope Rearrangement of Semibullvalene

(2020) Croix J. Laconsay et al.   JOURNAL OF ORGANIC CHEMISTRY

Structural and functional characterization of thermostable biocatalysts for the synthesis of 6-aminopurine nucleoside-5′-monophospate analogues

(2019) Jon Del Arco et al.   BIORESOURCE TECHNOLOGY

Whitening effect of l-ascorbate-2-phosphate trisodium salt on solar lentigos

(2019) Yuko Ishikawa et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters

(2019) Jian Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrophilic Aromatic Substitution Reactions: Mechanistic Landscape, Electrostatic and Electric-Field Control of Reaction Rates and Mechanistic Crossovers

(2019) Thijs Stuyver et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oriented External Electric Fields: Tweezers and Catalysts for Reactivity in Halogen-Bond Complexes

(2019) Chao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

(2019) Ashleigh J. Burke et al.   NATURE

The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

(2019) Ge Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile synthesis of D-xylulose-5-phosphate and L-xylulose-5-phosphate by xylulokinase-catalyzed phosphorylation

(2019) Norman Hardt et al.   BIOCATALYSIS AND BIOTRANSFORMATION

External electric field effects on chemical structure and reactivity

(2019) Thijs Stuyver et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Electric field–induced selective catalysis of single-molecule reaction

(2019) Xiaoyan Huang et al.   Science Advances

Fullerene-Based Switching Molecular Diodes Controlled by Oriented External Electric Fields

(2019) Adam Jaroš et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oriented Internal Electrostatic Fields Cooperatively Promote Ground- and Excited-State Reactivity: A Case Study in Photochemical CO2 Capture

(2019) Mitchell T. Blyth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart Nanoparticles for Selective Immobilization of Acid Phosphatases

(2018) Flóra Nagy et al.   ChemCatChem

Structure and reactivity/selectivity control by oriented-external electric fields

(2018) Sason Shaik et al.   CHEMICAL SOCIETY REVIEWS

Harnessing electrostatic catalysis in single molecule, electrochemical and chemical systems: a rapidly growing experimental tool box

(2018) Simone Ciampi et al.   CHEMICAL SOCIETY REVIEWS

Darwin Assembly: fast, efficient, multi-site bespoke mutagenesis

(2018) Christopher Cozens et al.   NUCLEIC ACIDS RESEARCH

Can electrostatic catalysis of Diels–Alder reactions be harnessed with pH-switchable charged functional groups?

(2018) Heather M. Aitken et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

(2018) Ryuhei Nagata et al.   Nature Communications

Elucidating the Roles of Electric Fields in Catalysis: A Perspective

(2018) Fanglin Che et al.   ACS Catalysis

Evaluation of Natural and Synthetic Phosphate Donors for the Improved Enzymatic Synthesis of Phosphate Monoesters

(2018) Gábor Tasnádi et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphine Organocatalysis

(2018) Hongchao Guo et al.   CHEMICAL REVIEWS

Oriented-External Electric Fields Create Absolute Enantioselectivity in Diels-Alder Reactions: The Importance of the Molecular Dipole Moment

(2018) Zhanfeng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Focused Library-Based Engineering of Candida antarctica Lipase B with (S )-Selectivity Towards sec -Alcohols

(2018) Yixin Cen et al.   ADVANCED SYNTHESIS & CATALYSIS

Computational Design of Synthetic Enzymes

(2018) Valerie Vaissier Welborn et al.   CHEMICAL REVIEWS

Electrostatic Switching between SN1 and SN2 Pathways

(2018) Li-Juan Yu et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Stereochemistry of electrophilic and nucleophilic substitution at phosphorus

(2018) Oleg I. Kolodiazhnyi   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes

(2018) Frédéric Cadet et al.   Scientific Reports

Enzymatic Production of Ascorbic Acid-2-phosphate by Recombinant Acid Phosphatase

(2017) Kai Zheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The ProTide Prodrug Technology: From the Concept to the Clinic

(2017) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Importance of the Scaffold for de Novo Enzymes: A Case Study with Kemp Eliminase

(2017) Asmit Bhowmick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrostatic and Charge-Induced Methane Activation by a Concerted Double C–H Bond Insertion

(2017) Caiyun Geng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electric-Field-Assisted Anion−π Catalysis

(2017) Masaaki Akamatsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational Optimization of Electric Fields for Improving Catalysis of a Designed Kemp Eliminase

(2017) Valerie Vaissier et al.   ACS Catalysis

Bioreaction Engineering Leading to Efficient Synthesis of L-Glyceraldehyd-3-Phosphate

(2017) Getachew S. Molla et al.   Biotechnology Journal

A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase

(2016) Yufan Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrostatic catalysis of a Diels–Alder reaction

(2016) Albert C. Aragonès et al.   NATURE

Oriented electric fields as future smart reagents in chemistry

(2016) Sason Shaik et al.   Nature Chemistry

Exploiting Acid Phosphatases in the Synthesis of Phosphorylated Monoalcohols and Diols

(2015) Gábor Tasnádi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Extreme electric fields power catalysis in the active site of ketosteroid isomerase

(2014) Stephen D. Fried et al.   SCIENCE

ChemShell-a modular software package for QM/MM simulations

(2013) Sebastian Metz et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

The Directive of the Protein: How Does Cytochrome P450 Select the Mechanism of Dopamine Formation?

(2011) Patric Schyman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

(2011) A. J. Adamczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oriented Electric Fields Accelerate Diels–Alder Reactions and Control theendo/exoSelectivity

(2010) Rinat Meir et al.   CHEMPHYSCHEM

External Electric Field Can Control the Catalytic Cycle of Cytochrome P450cam: A QM/MM Study

(2010) Wenzhen Lai et al.   Journal of Physical Chemistry Letters

Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization

(2010) S. C. L. Kamerlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA