The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states

Models of cognitive function typically focus on the cerebral cortex and hence overlook functional links to subcortical structures. This view does not consider the role of the highly-conserved ascending arousal system's role and the computational capacities it provides the brain. We test the hypothesis that the ascending arousal system modulates cortical neural gain to alter the low-dimensional energy landscape of cortical dynamics. Here we use spontaneous functional magnetic resonance imaging data to study phasic bursts in both locus coeruleus and basal forebrain, demonstrating precise time-locked relationships between brainstem activity, low-dimensional energy landscapes, network topology, and spatiotemporal travelling waves. We extend our analysis to a cohort of experienced meditators and demonstrate locus coeruleus-mediated network dynamics were associated with internal shifts in conscious awareness. Together, these results present a view of brain organization that highlights the ascending arousal system's role in shaping both the dynamics of the cerebral cortex and conscious awareness. Models of brain organisation can overlook the role of the autonomic nervous system in cognitive processes. Here the authors show a link between the ascending arousal system and both low dimensional neural dynamics and internal shifts in conscious awareness.

Automated summary

The authors demonstrate a connection between the ascending arousal system, low-dimensional neural dynamics, and internal shifts in conscious awareness, highlighting its role in shaping brain organization.