Article
Multidisciplinary Sciences
Marika Comegna, Gemma Conte, Andrea Patrizia Falanga, Maria Marzano, Gustavo Cernera, Antonella Miriam Di Lullo, Felice Amato, Nicola Borbone, Stefano D'Errico, Francesca Ungaro, Ivana d'Angelo, Giorgia Oliviero, Giuseppe Castaldo
Summary: Cystic fibrosis is characterized by airway obstruction caused by malfunctioning CFTR protein, and the main challenge in treatment is enhancing drug delivery to the lungs. This study reports the production and characterization of hybrid core-shell nanoparticles loaded with PNA for potential therapeutic use, showing their ability to overcome mucus barrier and release cargo in the cytoplasm.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Gleb S. S. Ivanov, Vyacheslav G. G. Tribulovich, Nikolay B. B. Pestov, Temitope I. I. David, Abdul-Saleem Amoah, Tatyana V. V. Korneenko, Nikolai A. A. Barlev
Summary: Peptide nucleic acids and other artificial genetic polymers have garnered significant interest from the scientific community since their discovery by Nielsen in 1991. Due to their unique biophysical properties, these artificial hybrid polymers are now widely used in various areas of therapy and diagnostics. This review provides an overview of their structure, rational design principles, and biophysical features, highlighting successful implementation in biology and biomedicine. The review also discusses areas of improvement for their future use as a new class of therapeutics.
Review
Cell Biology
Hong Dai, Razack Abdullah, Xiaoqiu Wu, Fangfei Li, Yuan Ma, Aiping Lu, Ge Zhang
Summary: Pancreatic cancer is a lethal cancer with limited effectiveness of current chemotherapy. Nucleic acid-based targeting therapies have shown promising progress in the treatment of pancreatic cancer, offering potential as a future treatment direction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Noah C. Cheng, Robert H. Vonderheide
Summary: The long-held desire to target the mutant KRAS gene therapeutically is being fulfilled with the development of small-molecule inhibitors. In addition to its role as a therapeutic target, KRAS also plays a crucial role in shaping the immunosuppressive nature of the tumor microenvironment. This opens up new possibilities for combination immunotherapy using mKRAS inhibitors.
Article
Chemistry, Multidisciplinary
Shipra Malik, Vikas Kumar, Chung-Hao Liu, Kuo-Chih Shih, Susan Krueger, Mu-Ping Nieh, Raman Bahal
Summary: This study successfully engineered PNA amphiphiles using chemically modified gamma PNA, which self-assembled into spherical vesicles and further formed nano-assemblies. A comprehensive comparison of the physicochemical properties and cellular uptake of PNA self-assembly and nano-assemblies was conducted.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Health Care Sciences & Services
Darren Cowzer, Mohammed Zameer, Michael Conroy, Walter Kolch, Austin G. Duffy
Summary: This article reviews therapeutic innovations targeting RAS signaling in pancreatic cancer from a clinical perspective. Despite the strong resistance of pancreatic cancer to treatment, new approaches such as inhibiting mutated KRAS, KRAS activators, and effectors show promise in breaking this therapeutic deadlock.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Fangfei Yin, Haipei Zhao, Shasha Lu, Juwen Shen, Min Li, Xiuhai Mao, Fan Li, Jiye Shi, Jiang Li, Baijun Dong, Wei Xue, Xiaolei Zuo, Xiurong Yang, Chunhai Fan
Summary: The article introduces a DNA-encoded molecular classifier that can classify multidimensional molecular clinical data and has been tested in prostate cancer patients.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hector Argueta-Gonzalez, Colin S. Swenson, Kornelia J. Skowron, Jennifer M. Heemstra
Summary: This article reports experimental research using bilingual PNA sequences, which can finely tune the assembly and disassembly properties of the polymers by adjusting the properties of amino acids and the spacing of nucleic acid sequences. This has important implications for applications such as drug encapsulation and delivery.
Article
Pharmacology & Pharmacy
Yongshu Li, Bihui Huang, Zhichao Xue, Yunhua Gao, Zhenjian Zhuo
Summary: This article highlights the development of nucleic acid therapy in pediatric cancers as a potential way to improve treatment outcomes, which should attract more attention.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
J. H. Strickler, H. Satake, T. J. George, R. Yaeger, A. Hollebecque, I Garrido-Laguna, M. Schuler, T. F. Burns, A. L. Coveler, G. S. Falchook, M. Vincent, Y. Sunakawa, L. Dahan, D. Bajor, S-Y Rha, C. Lemech, D. Juric, M. Rehn, G. Ngarmchamnanrith, P. Jafarinasabian, Q. Tran, D. S. Hong
Summary: This study evaluated the safety and efficacy of sotorasib in patients with KRAS p.G12C-mutated pancreatic cancer who had previously received treatment. The results showed that sotorasib demonstrated anticancer activity and had an acceptable safety profile in these patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Nikita Brodyagin, Aubrey L. Maryniak, Ilze Kumpina, John M. Talbott, Martins Katkevics, Eriks Rozners, James A. MacKay
Summary: Peptide nucleic acids (PNA) with extended isoorotamides containing nucleobases (I-o) were designed to bind A-U base pairs in double-stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments showed improved affinity for A-U using the Io scaffold in PNA, with PNAs having four sequential Io extended nucleobases maintaining high binding affinity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Analytical
Negar Bidar, Mohammad Amini, Fatemeh Oroojalian, Behzad Baradaran, Seyed Samad Hosseini, Mohammad-Ali Shahbazi, Mahmoud Hashemzaei, Ahad Mokhtarzadeh, Michael R. Hamblin, Miguel de la Guardia
Summary: The improvement of nucleic acid probes, particularly molecular beacons, plays a vital role in advancements in bioimaging, biosensing, and disorders diagnosis. Molecular beacons offer advantages such as target-specificity, unique structure, and high sensitivity, making them multi-tasking probes with applications in detecting various analytes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Medicine, General & Internal
Cornelis J. M. Melief
Summary: Pancreatic ductal adenocarcinoma is the deadliest of all common cancers. The study reported remarkable deep and durable tumor shrinkage in a heavily pretreated patient who received an infusion of autologous T cells transduced.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Fang Yuan, Mengnan Sun, Zhengsheng Liu, Huiqin Liu, Weijian Kong, Rui Wang, Feng Qian
Summary: Pancreatic cancer cells with high levels of macropinocytosis can be targeted using macropinocytic dextran as a delivery carrier. Conjugating triptolide with 70 kDa dextran enhances the therapeutic effects on KRAS mutant cells and preserves immune factors, reducing the impact on T cells.
Article
Chemistry, Multidisciplinary
Ruth Aizen, Zohar A. Arnon, Or Berger, Antonella Ruggiero, Dor Zaguri, Noam Brown, Evgeny Shirshin, Inna Slutsky, Ehud Gazit
Summary: Nucleobase crystals have unique fluorescence properties in the visible spectrum, unlike their monomeric counterparts. Additionally, some nucleobases exhibit a red edge excitation shift, which is uncommon in the field of organic supramolecular materials and may have implications in therapeutic and materials science.
NANOSCALE ADVANCES
(2023)
Editorial Material
Chemistry, Multidisciplinary
Stefano Fais, Lorraine O'Driscoll, Francesc E. Borras, Edit Buzas, Giovanni Camussi, Francesco Cappello, Joana Carvalho, Anabela Cordeiro da Silva, Hernando Del Portillo, Samir El Andaloussi, Tanja Ficko Trcek, Roberto Furlan, An Hendrix, Ihsan Gursel, Veronika Kralj-Iglic, Bertrand Kaeffer, Maja Kosanovic, Marilena E. Lekka, Georg Lipps, Mariantonia Logozzi, Antonio Marcilla, Marei Sammar, Alicia Llorente, Irina Nazarenko, Carla Oliveira, Gabriella Pocsfalvi, Lawrence Rajendran, Graca Raposo, Eva Rohde, Pia Siljander, Guillaume van Niel, M. Helena Vasconcelos, Maria Yanez-Mo, Marjo L. Yliperttula, Natasa Zarovni, Apolonija Bedina Zavec, Bernd Giebel
Article
Cell Biology
Marei Sammar, Monika Siwetz, Hamutal Meiri, Viktor Fleming, Peter Altevogt, Berthold Huppertz
HISTOCHEMISTRY AND CELL BIOLOGY
(2017)
Article
Developmental Biology
Marei Sammar, Rebecca Dragovic, Hamutal Meiri, Manu Vatish, Adi Sharabi-Nov, Ian Sargent, Chris Redman, Dionne Tannetta
Article
Obstetrics & Gynecology
Hamutal Meiri, Marei Sammar, Ayelet Herzog, Yael-Inna Grimpel, Galina Fihaman, Aliza Cohen, Vered Kivity, Adi Sharabi-Nov, Ron Gonen
JOURNAL OF PERINATAL MEDICINE
(2014)
Article
Multidisciplinary Sciences
Marei Sammar, Shahar Nisamblatt, Ron Gonen, Berthold Huppertz, Sveinbjorn Gizurarson, George Osol, Hamutal Meiri
Review
Biochemistry & Molecular Biology
Marei Sammar, Tijana Drobnjak, Maurizio Mandala, Sveinbjoern Gizurarson, Berthold Huppertz, Hamutal Meiri
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Marei Sammar, Basheer Abu-Farich, Ibrahim Rayan, Mizied Falah, Anwar Rayan
Review
Biochemical Research Methods
Alain Van Gool, Fernado Corrales, Mirjana Colovic, Danijela Krstic, Begona Oliver-Martos, Eva Martinez-Caceres, Ivone Jakasa, Goran Gajski, Virginie Brun, Kyriacos Kyriacou, Izabela Burzynska-Pedziwiatr, Lucyna Alicja Wozniak, Stephan Nierkens, Cesar Pascual Garcia, Jaroslav Katrlik, Zanka Bojic-Trbojevic, Jan Vacek, Alicia Llorente, Felicia Antohe, Viorel Suica, Guillaume Suarez, Ruben T'Kindt, Petra Martin, Deborah Penque, Ines Lanca Martins, Ede Bodoki, Bogdan-Cezar Iacob, Eda Aydindogan, Suna Timur, John Allinson, Christopher Sutton, Theo Luider, Saara Wittfooth, Marei Sammar
EXPERT REVIEW OF PROTEOMICS
(2020)
Review
Oncology
Peter Altevogt, Marei Sammar, Laura Hueser, Glen Kristiansen
Summary: CD24 is a highly glycosylated protein expressed primarily by immune cells and often overexpressed in human tumors. It plays a role in regulating cell migration, invasion and proliferation in cancer, associated with poor prognosis and used as a cancer stemness marker. The review summarizes recent progress on the role of CD24-Siglec-10 binding axis in tumor immunity and the potential of CD24-based immunotherapy in cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Marei Sammar, Monika Siwetz, Hamutal Meiri, Adi Sharabi-Nov, Peter Altevogt, Berthold Huppertz
Summary: This study revealed lower expression of CD24 mRNA in early pregnancy stages compared to normal term delivery, with a further decrease in preterm PE cases, indicating a potential link to reduced immune tolerance in preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marei Sammar, Clara Apicella, Peter Altevogt, Hamutal Meiri, Daniel Vaiman
Summary: In this study, two cell lines were used to simulate the features of preeclampsia, and it was found that CD24 expression was reduced in cells overexpressing the STOX1-A/B transcription factor. These results reinforce the importance of reduced CD24 levels in early and preterm preeclampsia, as observed in in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Eric A. Ben-David, Maryana Habibi, Elias Haddad, Marei Sammar, Dror L. Angel, Hila Dror, Haim Lahovitski, Andy M. Booth, Isam Sabbah
Summary: This study aims to understand the capture mechanism of nanoplastics (NPs) by jellyfish mucus and compare it with conventional coagulants and mucus from other organisms. The results show that jellyfish mucus has a higher efficiency in capturing NPs compared to other mucus types and coagulants, suggesting its potential as a bio-flocculant.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Marina Marks Kazatsker, Adi Sharabi-Nov, Hamutal Meiri, Rami Sammour, Marei Sammar
Summary: This study aimed to compare the levels of placental protein 13 (PP13) carried by placental-associated extracellular vesicles (PEVs) and the known soluble fraction in the maternal circulation of patients with preterm preeclampsia (PE), preterm delivery (PTD), and term delivery. The results showed that the levels of PP13 carried by PEVs were significantly increased, especially in preterm PE patients who received corticosteroid treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Tijana Drobnjak, Anna Margret Jonsdottir, Helga Helgadottir, Margret Soffia Runolfsdottir, Hamutal Marei, Marei Sammar, George Osol, Maurizio Mandala, Berthold Huppertz, Sveinbjorn Gizurarson
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2019)