Article
Cell Biology
Qiuyan Zhao, Yingchun Ren, Haoran Xie, Lanting Yu, Jiawei Lu, Weiliang Jiang, Wenqin Xiao, Zhonglin Zhu, Rong Wan, Baiwen Li
Summary: The study found that ELK3 levels were higher in PDAC tissues than in adjacent normal tissues. ELK3 acted as an oncogene to promote tumorigenesis and metastasis in PDAC. Further research suggested that ELK3 promoted PDAC cell migration and invasion by activating the Wnt/beta-catenin pathway, and ZEB1 could directly bind to the promoter of ELK3 to increase its transcription.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Zhi Li, Hai-Yan Yang, Xiao-Lan Zhang, Xu Zhang, Yu-Zhou Huang, Xin-Yuan Dai, Liang Shi, Guo-Ren Zhou, Ji-Fu Wei, Qiang Ding
Summary: This study revealed that KIF23 is up-regulated in TNBC and is associated with poor prognosis. KIF23 promotes TNBC proliferation, migration, and invasion by activating the Wnt/beta-catenin pathway and inducing epithelial-mesenchymal transition (EMT). The WDR5/FOXM1/KIF23/Wnt/beta-catenin axis may serve as a promising therapeutic target for TNBC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruimin Zhao, Shiyang Wang, Lu Tan, Huajing Li, Junsong Liu, Shaoqiang Zhang
Summary: The study found that IGFL2-AS1 was highly expressed in tongue squamous cell carcinoma (TSCC) and had an impact on cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). IGFL2-AS1 acted as a competing endogenous RNA (ceRNA) by regulating the expression of miR-1224-5p and SATB homeobox 1 (SATB1), thereby regulating the Wnt/beta-catenin signaling pathway and TSCC progression.
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Correction
Oncology
Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang, Jie Zhong
Summary: An amendment to the paper has been published and is accessible through the original article.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Kun Cai, Lu Deng, Dijie Zheng, Lin Li, Zhiwei He, Chao Yu
Summary: MICAL1 is upregulated in pancreatic cancer and promotes the progression of cancer cells by activating the WNT/beta-catenin signaling pathway. Therefore, MICAL1 may be a potential therapeutic target for pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Guanyou Huang, Yujuan Wu, Yonggui Du, Hongchuan Gan, Shuyu Hao
Summary: The miR-138-5p/MeCP2/Wnt/b-catenin signaling pathway may serve as a new target for glioma treatment.
WORLD NEUROSURGERY
(2023)
Review
Cell Biology
Tiziana Napolitano, Serena Silvano, Chaima Ayachi, Magali Plaisant, Anette Sousa-Da-Veiga, Hugo Fofo, Benjamin Charles, Patrick Collombat
Summary: The pancreas plays two vital roles in the human body: assisting in food digestion through the secretion of digestive enzymes and regulating blood glucose levels through the release of endocrine hormones. Recent research has shown that the Wnt/beta-catenin signaling pathway is instrumental in the development and function of the pancreas, from embryonic development to adulthood. Understanding the role of this pathway is crucial for the development of new therapies for pancreatic diseases.
Article
Cell Biology
Meng Cui, Yu Chang, Jiheng Wang, Junfu Wu, Gang Li, Jie Tan
Summary: The expression and function of ERCC6L in laryngeal squamous cell carcinoma (LSCC) were investigated. ERCC6L was found to be upregulated in LSCC and correlated with TNM stage. Knockdown of ERCC6L resulted in decreased proliferation and migration, increased apoptosis, and reactive oxygen species (ROS) in LSCC cells. Mechanistically, ERCC6L promoted the binding of FOXM1 and KIF4A in LSCC cells, driving their progression. Targeting ERCC6L may provide a promising strategy for precision therapy in LSCC.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Retraction
Oncology
Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang, Jie Zhong
Summary: This article has been retracted. Please refer to the Retraction Notice for more details.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Anatomy & Morphology
Chunyi Ji, Lijian Chen, Miaoxian Yuan, Weixin Xie, Xinyi Sheng, Qiang Yin
Summary: This study investigates the mechanism of KDM1A-regulated hepatoblastoma (HB) development. The expression levels of KDM1A and DKK3 were analyzed in HB patients, and experiments were conducted on cell lines and nude mice to study the effects of knockdown of KDM1A and DKK3. The results suggest that KDM1A stimulates HB development by activating the Wnt/beta-catenin pathway through inhibition of DKK3 transcription.
Article
Biotechnology & Applied Microbiology
Ben Yang, Fengling Wang, Gang Zheng
Summary: This study investigated the role of TMEM119 in breast cancer progression and found that TMEM119 overexpression is associated with poor survival in patients. Knockdown of TMEM119 reduced stemness marker expression. RNA-sequencing and Co-IP experiments confirmed the relationship between TMEM119 and Wnt/beta-catenin signaling pathway.
Article
Oncology
Zhongbao Shao, Chang Yuan, Junbao Hu, Yuli Wu, Chong Zeng
Summary: This study found that circ_0003789 is upregulated in gastric cancer and is positively associated with tumor differentiation, distal metastasis, and advanced clinical stage. Silencing circ_0003789 can inhibit gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition, possibly through the repression of the Wnt/beta-catenin signaling pathway.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Biochemistry & Molecular Biology
Sisi Chen, Yunyan Du, Bin Xu, Qing Li, Le Yang, Zi Jiang, Zhaoxia Zeng, Leifeng Chen
Summary: Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and sorafenib is currently the only FDA-approved first-line targeted drug for advanced HCC. However, studies have shown that the imbalance between apoptosis and autophagy plays a key role in chemoresistance, and VRK2 has been identified as a factor contributing to sorafenib resistance in HCC by disrupting this balance. Targeting VRK2 to modulate the balance between autophagy and apoptosis may offer a new strategy for overcoming sorafenib resistance in HCC.
Review
Biochemistry & Molecular Biology
Peijun Zhu, Ting Li, Qingqing Li, Yawen Gu, Yuan Shu, Kaibo Hu, Leifeng Chen, Xiaogang Peng, Jie Peng, Liang Hao
Summary: Osteosarcoma, the most common malignant bone tumor, has a poor prognosis and low sensitivity to current treatment methods. Endoplasmic reticulum stress (ERS) has been found to play a role in regulating osteosarcoma proliferation, apoptosis, and chemoresistance through the unfolded protein response (UPR) pathway. Further research on the relationship between ERS and osteosarcoma could lead to the development of more effective treatment strategies.
Article
Oncology
Yumin Qiu, Hengqing Zhu, Debin Xu, Qian Feng, Chongyu Wen, Yunyan Du, Mingfeng Xiang, Leifeng Chen, Xiaogang Peng
Summary: In pancreatic cancer, the E3 ubiquitin ligase RING-finger protein 6 (RNF6) was found to promote tumor metastasis by enhancing c-Myc-mediated aerobic glycolysis. This indicates that RNF6 may serve as a potential novel biomarker in pancreatic cancer carcinogenesis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Leifeng Chen, Rongfa Yuan, Chongyu Wen, Tiande Liu, Qian Feng, Xueqiang Deng, Yunyan Du, Xiaogang Peng
Summary: In pancreatic cancer patients, UBR5 levels were significantly upregulated and closely related to the malignant phenotype and shorter survival. UBR5 contributes to the growth of pancreatic cancer cells by inducing aerobic glycolysis and regulates FBP1 expression by modulating C/EBP alpha.