Bacterial Approaches for Assembling Iron-Sulfur Proteins

Biosynthesis of Nitrogenase Cofactors

(2020) Stefan Burén et al.   CHEMICAL REVIEWS

The transcriptional regulator IscR integrates host-derived nitrosative stress and iron starvation in activation of the vvhBA operon in Vibrio vulnificus

(2020) Garam Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SufR, a [4Fe-4S] cluster-containing transcription factor, represses the sufRBDCSU operon in the iron-sulfur cluster assembly in Streptomyces avermitilis

(2020) Yaqing Cheng et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli

(2020) Chelsey R Fontenot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small RNA controls bacterial sensitivity to gentamicin during iron starvation

(2019) Sylvia Chareyre et al.   PLoS Genetics

Iron-sulfur cluster repair contributes to Y. pseudotuberculosis survival within deep tissues.

(2019) Kimberly M. Davis et al.   INFECTION AND IMMUNITY

The SUF system: an ABC ATPase-dependent protein complex with a role in Fe–S cluster biogenesis

(2019) Pierre Simon Garcia et al.   RESEARCH IN MICROBIOLOGY

Elevated Expression of a Functional Suf Pathway in E. coli BL21(DE3) Enhances Recombinant Production of an Iron-Sulfur Cluster Protein.

(2019) Elliot I. Corless et al.   JOURNAL OF BACTERIOLOGY

The ErpA/NfuA complex builds an oxidation-resistant Fe-S cluster delivery pathway

(2018) Béatrice Py et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Release of nitric oxide by the Escherichia coli YtfE (RIC) protein and its reduction by the hybrid cluster protein in an integrated pathway to minimize cytoplasmic nitrosative stress

(2018) Basema Balasiny et al.   MICROBIOLOGY-SGM

Distinct roles for U-type proteins in iron-sulfur cluster biosynthesis revealed by genetic analysis of the Bacillus subtilis sufCDSUB operon

(2018) Nao Yokoyama et al.   MOLECULAR MICROBIOLOGY

Iron-sulfur protein maturation in Helicobacter pylori : identifying a Nfu-type cluster carrier protein and its iron-sulfur protein targets

(2018) Stéphane L. Benoit et al.   MOLECULAR MICROBIOLOGY

Rv1460, a SufR homologue, is a repressor of the suf operon in Mycobacterium tuberculosis

(2018) Danicke Willemse et al.   PLoS One

The role of chaperones in iron sulfur cluster biogenesis

(2018) Rita Puglisi et al.   FEBS LETTERS

The di-iron RIC (YtfE) protein of Escherichia coli interacts with the DNA-binding protein from starved cells (Dps) to diminish RIC-protein-mediated redox stress

(2018) Liliana S. O. Silva et al.   JOURNAL OF BACTERIOLOGY

Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change

(2018) Jeffrey N. Carey et al.   CELL

Evidence that a respiratory shield in Escherichia coli protects a low-molecular-mass FeII pool from O2-dependent oxidation

(2018) Joshua D. Wofford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The A-type domain in Escherichia coli NfuA is required for regenerating the auxiliary [4Fe–4S] cluster in Escherichia coli lipoyl synthase

(2018) Erin L. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Branched late-steps of the cytosolic iron-sulphur cluster assembly machinery of Trypanosoma brucei

(2018) Maiko Luis Tonini et al.   PLoS Pathogens

Impaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureus

(2017) Ameya A Mashruwala et al.   eLife

The Staphylococcus aureus SrrAB Regulatory System Modulates Hydrogen Peroxide Resistance Factors, Which Imparts Protection to Aconitase during Aerobic Growth

(2017) Ameya A. Mashruwala et al.   PLoS One

The iron-sulfur cluster sensor IscR is a negative regulator of Spi1 type III secretion system in Salmonella enterica

(2016) Alexandra Vergnes et al.   CELLULAR MICROBIOLOGY

Crystal Structure Analysis of the Repair of Iron Centers Protein YtfE and Its Interaction with NO

(2016) Feng-Chun Lo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metallocofactor assembly for [FeFe]-hydrogenases

(2016) Pedro Dinis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Staphylococcus aureusSufT: an essential iron-sulphur cluster assembly factor in cells experiencing a high-demand for lipoic acid

(2016) Ameya A. Mashruwala et al.   MOLECULAR MICROBIOLOGY

A Regulatory Circuit Composed of a Transcription Factor, IscR, and a Regulatory RNA, RyhB, Controls Fe-S Cluster Delivery

(2016) Pierre Mandin et al.   mBio

The DUF59 Containing Protein SufT Is Involved in the Maturation of Iron-Sulfur (FeS) Proteins during Conditions of High FeS Cofactor Demand in Staphylococcus aureus

(2016) Ameya A. Mashruwala et al.   PLoS Genetics

Shared-intermediates in the biosynthesis of thio-cofactors: Mechanism and functions of cysteine desulfurases and sulfur acceptors

(2015) Katherine A. Black et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron–sulfur cluster assembly

(2015) Robert Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Physiological roles of bacillithiol in intracellular metal processing

(2015) Zuelay Rosario-Cruz et al.   CURRENT GENETICS

IscR Regulates Synthesis of Colonization Factor Antigen I Fimbriae in Response to Iron Starvation in Enterotoxigenic Escherichia coli

(2015) Sara Haines et al.   JOURNAL OF BACTERIOLOGY

Functional Dynamics Revealed by the Structure of the SufBCD Complex, a Novel ATP-binding Cassette (ABC) Protein That Serves as a Scaffold for Iron-Sulfur Cluster Biogenesis

(2015) Kei Hirabayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IscR plays a role in oxidative stress resistance and pathogenicity of a plant pathogen, Xanthomonas campestris

(2015) Mayuree Fuangthong et al.   MICROBIOLOGICAL RESEARCH

Bacillithiol has a role in Fe-S cluster biogenesis inStaphylococcus aureus

(2015) Zuelay Rosario-Cruz et al.   MOLECULAR MICROBIOLOGY

Life without Fe-S clusters

(2015) Agostinho G. Rocha et al.   MOLECULAR MICROBIOLOGY

Novel features of the ISC machinery revealed by characterization of Escherichia coli mutants that survive without iron-sulfur clusters

(2015) Naoyuki Tanaka et al.   MOLECULAR MICROBIOLOGY

The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis inEscherichia coli

(2015) Béatrice Roche et al.   MOLECULAR MICROBIOLOGY

Turning Escherichia coli into a Frataxin-Dependent Organism

(2015) Béatrice Roche et al.   PLoS Genetics

Protective role of bacillithiol in superoxide stress and Fe-S metabolism inBacillus subtilis

(2015) Zhong Fang et al.   MicrobiologyOpen

Sulfur Mobilization for Fe-S Cluster Assembly by the Essential SUF Pathway in the Plasmodium falciparum Apicoplast and Its Inhibition

(2014) Manish Charan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interplay between Oxygen and Fe–S Cluster Biogenesis: Insights from the Suf Pathway

(2014) Eric S. Boyd et al.   BIOCHEMISTRY

SnapShot: Eukaryotic Fe-S Protein Biogenesis

(2014) Viktoria Désirée Paul et al.   Cell Metabolism

Alternative FeS cluster ligands: tuning redox potentials and chemistry

(2014) Daniel W Bak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of IscX in Iron–Sulfur Cluster Biogenesis in Escherichia coli

(2014) Jin Hae Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence inStaphylococcus aureus

(2014) Ameya A. Mashruwala et al.   MOLECULAR MICROBIOLOGY

Copper binding in IscA inhibits iron-sulphur cluster assembly inEscherichia coli

(2014) Guoqiang Tan et al.   MOLECULAR MICROBIOLOGY

Escherichia coli RIC Is Able to Donate Iron to Iron-Sulfur Clusters

(2014) Lígia S. Nobre et al.   PLoS One

Crystal Structures of Nucleotide-Free and Glutathione-Bound Mitochondrial ABC Transporter Atm1

(2014) V. Srinivasan et al.   SCIENCE

Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies

(2014) M. D. Valentino et al.   mBio

IscR Is Essential for Yersinia pseudotuberculosis Type III Secretion and Virulence

(2014) Halie K. Miller et al.   PLoS Pathogens

Fe-S Cluster Biogenesis in Gram-Positive Bacteria: SufU Is a Zinc-Dependent Sulfur Transfer Protein

(2013) Bruna P. Selbach et al.   BIOCHEMISTRY

Protected Sulfur Transfer Reactions by the Escherichia coli Suf System

(2013) Bruna P. Selbach et al.   BIOCHEMISTRY

Iron/sulfur proteins biogenesis in prokaryotes: Formation, regulation and diversity

(2013) Béatrice Roche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins

(2013) Oliver Stehling et al.   Cell Metabolism

IscR Is a Global Regulator Essential for Pathogenesis of Vibrio vulnificus and Induced by Host Cells

(2013) Jong Gyu Lim et al.   INFECTION AND IMMUNITY

Physical and Functional Interactions of a Monothiol Glutaredoxin and an Iron Sulfur Cluster Carrier Protein with the Sulfur-donating RadicalS-Adenosyl-l-methionine Enzyme MiaB

(2013) Sylvain Boutigny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferredoxin Competes with Bacterial Frataxin in Binding to the Desulfurase IscS

(2013) Robert Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IscR Modulates Catalase A (KatA) Activity, Peroxide Resistance, and Full Virulence of Pseudomonas aeruginosa PA14

(2013) Seol-Hee Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Monothiol Glutaredoxins Can Bind Linear [Fe3S4]+ and [Fe4S4]2+ Clusters in Addition to [Fe2S2]2+ Clusters: Spectroscopic Characterization and Functional Implications

(2013) Bo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[2Fe-2S]-Ferredoxin Binds Directly to Cysteine Desulfurase and Supplies an Electron for Iron–Sulfur Cluster Assembly but Is Displaced by the Scaffold Protein or Bacterial Frataxin

(2013) Jin Hae Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo[Fe-S] cluster acquisition by IscR and NsrR, two stress regulators inEscherichia coli

(2013) Daniel Vinella et al.   MOLECULAR MICROBIOLOGY

Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity

(2013) Senapathy Rajagopalan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway

(2013) B. Ezraty et al.   SCIENCE

Spectroscopic and Functional Characterization of Iron–Sulfur Cluster-Bound Forms of Azotobacter vinelandiiNifIscA

(2012) Daphne T. Mapolelo et al.   BIOCHEMISTRY

Effector Role Reversal during Evolution: The Case of Frataxin in Fe–S Cluster Biosynthesis

(2012) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Characterization of the [2Fe-2S] Cluster of Escherichia coli Transcription Factor IscR

(2012) Angela S. Fleischhacker et al.   BIOCHEMISTRY

Iron binding activity is essential for the function of IscA in iron–sulphur cluster biogenesis

(2012) Aaron P. Landry et al.   DALTON TRANSACTIONS

TheE. coliSufS-SufE sulfur transfer system is more resistant to oxidative stress than IscS-IscU

(2012) Yuyuan Dai et al.   FEBS LETTERS

Separate FeS scaffold and carrier functions for SufB2C2 and SufA during in vitro maturation of [2Fe2S] Fdx

(2012) Harsimranjit K. Chahal et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Glutathione Complexed Fe–S Centers

(2012) Wenbin Qi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular organization, biochemical function, cellular role and evolution of NfuA, an atypical Fe-S carrier

(2012) Béatrice Py et al.   MOLECULAR MICROBIOLOGY

The DUF59 Family GeneAE7Acts in the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Maintain Nuclear Genome Integrity inArabidopsis

(2012) Dexian Luo et al.   PLANT CELL

TheE. coliMonothiol Glutaredoxin GrxD Forms Homodimeric and Heterodimeric FeS Cluster Containing Complexes

(2011) N. Yeung et al.   BIOCHEMISTRY

Glutathione: a key component of the cytoplasmic labile iron pool

(2011) Robert C. Hider et al.   BIOMETALS

Decreased Transport Restores Growth of a Salmonella enterica apbC Mutant on Tricarballylate

(2011) J. M. Boyd et al.   JOURNAL OF BACTERIOLOGY

SufD and SufC ATPase Activity Are Required for Iron Acquisition during in Vivo Fe-S Cluster Formation on SufB

(2010) Avneesh Saini et al.   BIOCHEMISTRY

Kinetic Analysis of the Bisubstrate Cysteine Desulfurase SufS fromBacillus subtilis

(2010) Bruna Selbach et al.   BIOCHEMISTRY

Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes

(2010) Eva Biegel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Iron-Sulfur (Fe-S) Cluster Assembly

(2010) Silke Wollers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Is Not the Sulfur Source for Iron-Sulfur Cluster and Methionine Biosynthesis in the Methanogenic ArchaeonMethanococcus maripaludis

(2010) Yuchen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life

(2010) J. C. Waller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

(2010) Filippo Prischi et al.   Nature Communications

Structural Basis for Delivery of the Intact [Fe2S2] Cluster by Monothiol Glutaredoxin

(2009) Thomas Iwema et al.   BIOCHEMISTRY

Small RNA-induced differential degradation of the polycistronic mRNA iscRSUA

(2009) Guillaume Desnoyers et al.   EMBO JOURNAL

Resistance of Haemophilus influenzae to Reactive Nitrogen Donors and Gamma Interferon-Stimulated Macrophages Requires the Formate-Dependent Nitrite Reductase Regulator-Activated ytfE Gene

(2009) J. C. Harrington et al.   INFECTION AND IMMUNITY

Sequence-Specific Binding to a Subset of IscR-Regulated Promoters Does Not Require IscR Fe–S Cluster Ligation

(2009) A.D. Nesbit et al.   JOURNAL OF MOLECULAR BIOLOGY

NsrR targets in theEscherichia coligenome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility

(2009) Jonathan D. Partridge et al.   MOLECULAR MICROBIOLOGY

Bacillithiol is an antioxidant thiol produced in Bacilli

(2009) Gerald L Newton et al.   Nature Chemical Biology

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron-Sulfur (Fe/S) Protein Biogenesis: Phylogenomic and Genetic Studies of A-Type Carriers

(2009) Daniel Vinella et al.   PLoS Genetics

Studies on the Mechanism of Catalysis of Iron−Sulfur Cluster Transfer from IscU[2Fe2S] by HscA/HscB Chaperones†

(2008) Francesco Bonomi et al.   BIOCHEMISTRY

Bacterial ApbC Can Bind and Effectively Transfer Iron−Sulfur Clusters†‡

(2008) Jeffrey M. Boyd et al.   BIOCHEMISTRY

Oxidant-Responsive Induction of the suf Operon, Encoding a Fe-S Assembly System, through Fur and IscR in Escherichia coli

(2008) K.-C. Lee et al.   JOURNAL OF BACTERIOLOGY

IscR Controls Iron-Dependent Biofilm Formation in Escherichia coli by Regulating Type I Fimbria Expression

(2008) Y. Wu et al.   JOURNAL OF BACTERIOLOGY

Analysis of yggX and gshA Mutants Provides Insights into the Labile Iron Pool in Salmonella enterica

(2008) M. P. Thorgersen et al.   JOURNAL OF BACTERIOLOGY

Widespread Distribution in Pathogenic Bacteria of Di-Iron Proteins That Repair Oxidative and Nitrosative Damage to Iron-Sulfur Centers

(2008) T. W. Overton et al.   JOURNAL OF BACTERIOLOGY

Salmonella enterica Requires ApbC Function for Growth on Tricarballylate: Evidence of Functional Redundancy between ApbC and IscU

(2008) J. M. Boyd et al.   JOURNAL OF BACTERIOLOGY

NfuA, a New Factor Required for Maturing Fe/S Proteins inEscherichia coliunder Oxidative Stress and Iron Starvation Conditions

(2008) Sandra Angelini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of Iron-Sulfur Clusters in Photosystem I

(2008) Zhao Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proposed Role for theAzotobacter vinelandiiNfuA Protein as an Intermediate Iron-Sulfur Cluster Carrier

(2008) Sibali Bandyopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of Fe/S proteins and pathogenicity: IscR plays a key role in allowing Erwinia chrysanthemi to adapt to hostile conditions

(2008) Gabriel Rincon-Enriquez et al.   MOLECULAR MICROBIOLOGY

eSGA: E. coli synthetic genetic array analysis

(2008) Gareth Butland et al.   NATURE METHODS

Inactivation of [Fe-S] Metalloproteins Mediates Nitric Oxide-Dependent Killing of Burkholderia mallei

(2008) Jessica Jones-Carson et al.   PLoS One

Hydrodynamic characterization of the SufBC and SufCD complexes and their interaction with fluorescent adenosine nucleotides

(2008) Arsen Petrovic et al.   PROTEIN SCIENCE