4.3 Review

Review of the algorithms used in exhaled breath analysis for the detection of diabetes

Journal

JOURNAL OF BREATH RESEARCH
Volume 16, Issue 2, Pages -

Publisher

IOP Publishing Ltd
DOI: 10.1088/1752-7163/ac4916

Keywords

exhaled breath analysis; diabetes; algorithms; neural network; PCA; KNN; SVM

Funding

  1. National Centre of Research and Development [Rzeczy sa dla ludzi/0089/2020]

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Currently, intensive research is being conducted on the development of truly noninvasive medical diagnostic systems, including respiratory analysers based on the detection of biomarkers for various diseases like diabetes. Selective detection of diabetes biomarkers in exhaled breath is crucial, with algorithms trained to detect diabetes achieving over 90% accuracy in most cases.Various measurement systems, feature extraction methods, and algorithms such as support vector machines are being used to detect diabetes in patient samples and simulated artificial breath samples.
Currently, intensive work is underway on the development of truly noninvasive medical diagnostic systems, including respiratory analysers based on the detection of biomarkers of several diseases including diabetes. In terms of diabetes, acetone is considered as a one of the potential biomarker, although is not the single one. Therefore, the selective detection is crucial. Most often, the analysers of exhaled breath are based on the utilization of several commercially available gas sensors or on specially designed and manufactured gas sensors to obtain the highest selectivity and sensitivity to diabetes biomarkers present in the exhaled air. An important part of each system are the algorithms that are trained to detect diabetes based on data obtained from sensor matrices. The prepared review of the literature showed that there are many limitations in the development of the versatile breath analyser, such as high metabolic variability between patients, but the results obtained by researchers using the algorithms described in this paper are very promising and most of them achieve over 90% accuracy in the detection of diabetes in exhaled air. This paper summarizes the results using various measurement systems, feature extraction and feature selection methods as well as algorithms such as support vector machines, k-nearest neighbours and various variations of neural networks for the detection of diabetes in patient samples and simulated artificial breath samples.

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