Journal
VIRUSES-BASEL
Volume 14, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/v14010015
Keywords
human cytomegalovirus; nuclear egress; virus assembly; virus-cell interactions
Categories
Funding
- NIH [R01AI035602, 1R01AI120619]
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The assembly of human cytomegalovirus involves changes in cellular architecture, metabolism, protein trafficking, and cellular homeostatic functions. The nuclear egress of HCMV nucleocapsids follows a pathway similar to other members of the herpesvirus family, and the virus encodes viral functions that exploit cellular functions to overcome barriers and bridge the nuclear membrane. This review provides an overview of our understanding of HCMV egress, with a focus on the more well-studied α-herpesviruses, HSV-1 and PRV.
The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked increases in nuclear size and structure as well as the reorganization of membranes in cytoplasm. Similarly, significant changes occur in cellular metabolism, protein trafficking, and cellular homeostatic functions. These cellular modifications are considered integral in the efficient assembly of infectious progeny in productively infected cells. Nuclear egress of HCMV nucleocapsids is thought to follow a pathway similar to that proposed for other members of the herpesvirus family. During this process, viral nucleocapsids must overcome structural barriers in the nucleus that limit transit and, ultimately, their delivery to the cytoplasm for final assembly of progeny virions. HCMV, similar to other herpesviruses, encodes viral functions that co-opt cellular functions to overcome these barriers and to bridge the bilaminar nuclear membrane. In this brief review, we will highlight some of the mechanisms that define our current understanding of HCMV egress, relying heavily on the current understanding of egress of the more well-studied alpha-herpesviruses, HSV-1 and PRV.
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