Article
Plant Sciences
Yue Shen, Li Teng, Yuhan Qu, Jie Liu, Xudong Zhu, Shan Chen, Longfei Yang, Yuehui Huang, Qin Song, Qiang Fu
Summary: The dried aboveground part of Geranium Wilfordii Maxim., known as lao-guan-cao in Traditional Chinese Medicine, has been used for its anti-inflammatory and anti-proliferation activities. Specifically, the compound Corilagin (COR) found in this plant has shown various pharmacological effects, such as anti-inflammatory, anti-tumor, and anti-microbial properties. In a study focusing on rheumatoid arthritis (RA), COR demonstrated anti-proliferation and anti-inflammation effects by inhibiting synovial fibroblasts and suppressing inflammatory responses through NF-kappa B and MAPK signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Lei Wang, Pengfei Li, Yu Zhou, Renjun Gu, Ge Lu, Chunbing Zhang
Summary: This study investigated the effects of Magnoflorine (Mag) on rheumatoid arthritis (RA) and the underlying mechanism using mouse models. The results showed that Mag could reduce arthritis severity, joint destruction, and macrophage infiltration. Further analysis revealed that Mag exerted its anti-arthritic and anti-inflammatory effects by inhibiting the activation of NF-kappa B and MAPK signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Chang Shu, Jun Chen, Meiyan Lv, Yiyuan Xi, Jujia Zheng, Xiangwei Xu
Summary: Plumbagin may attenuate RA-induced damage to cells and joints by down-regulating the levels of inflammatory cytokines and MMPs through inhibiting the activation of the NF-kappa B pathway.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Xiaojiang Yang, Hong Qian, Jia Meng, Hui Jiang, Tao Yuan, Shaoqiang Yang, Yibin Luo, Ninrong Bao, Jianning Zhao, Dongsheng Wang
Summary: The aim of this study was to evaluate the anti-rheumatoid arthritis (RA) effect of Lonicerin (LON), a safe compound with anti-inflammatory and immunomodulatory properties. LON treatment attenuated the disease progression of CIA mice with lower paw swelling, clinical score, mobility, and inflammatory response. Mechanistically, LON regulated the polarization of M1/M2 macrophages, especially by inhibiting macrophage polarization toward M1, and inhibited NF-kappa B signaling pathway and NLRP3 inflammasome activation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Feng Cao, Cheng Huang, Jiwei Cheng, Zhaochun He
Summary: The study demonstrated that upregulation of beta Arr2 levels can improve symptoms and pathological damage in RA, attenuate inflammatory responses, and effectively alleviate ankle inflammation in CIA mice via the NF-kappa B/NLRP3 inflammasome pathway.
Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shuyan Sheng, Xinyi Wang, Xin Liu, Xinyang Hu, Yubao Shao, Gaoyuan Wang, Deshen Mao, Conghan Li, Bangjie Chen, Xiaoyu Chen
Summary: This review explores the therapeutic effects of resveratrol on rheumatoid arthritis (RA) by activating the SIRT1 pathway. It also discusses the crosstalk between SIRT1 and NF-kappa B pathways, and their role in the development of RA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Ling, Jie Yang, Di Hua, Dawei Wang, Chenglei Zhao, Ling Weng, Dandan Yue, Xueting Cai, Qinghai Meng, Jiao Chen, Xiaoyan Sun, Weikang Kong, Lizhong Zhu, Peng Cao, Chunping Hu
Summary: The study found that ZhiJingSan delayed the onset of arthritis, alleviated joint inflammation, and reduced bone erosion in CIA mice. Additionally, ZJS decreased serum levels of TNF-alpha, IL-6, and reduced the number of osteoclasts, as well as the expression of MMP9 and cathepsin K in the ankle joints of CIA mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yi-jin Wu, Wen-juan Fang, Shu Pan, Sa-sa Zhang, Dan-feng Li, Zhong-fang Wang, Wen -gang Chen, Qin Yin, Jian Zuo
Summary: Rheumatoid arthritis is a systemic autoimmune disease characterized by metabolic disorders, with Sirt1 playing a significant role in regulating energy metabolism and immune functions. The potential of Sirt1-targeting anti-rheumatic regimens is highlighted as a promising therapeutic strategy for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Chenyang Han, Yi Yang, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Li Guo, Caiqun Zhang, Qiao Ye
Summary: The study found that Gla B can inhibit NF-kappa B signaling by regulating M1 polarization of SMG, thereby suppressing articular cartilage inflammation injury in RA. Additionally, Gla B can target the P65 protein and inhibit joint injury and inflammation in mice.
Article
Chemistry, Medicinal
Chao Zhu, Shuang Wen, Junyong Li, Hongyu Meng, Junzhe Zhang, Kuo Zhao, Ling Wang, Yingze Zhang
Summary: The study demonstrated that Fingolimod exerts beneficial effects in collagen-induced arthritis (CIA) mice by inhibiting the recruitment of CD4(+) T lymphocytes to the affected joints. Additionally, Fingolimod inhibits TNF-alpha-induced inflammation by suppressing the AKT/PI3K/NF-kappa B signaling pathway in MH7A cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Dahu Qi, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao
Summary: Pristimerin exerts potential therapeutic effects on osteoporosis by inhibiting NF-kappa B and MAPK signaling pathways, reducing ROS production, activating Nrf2/HO-1 signaling pathway, and affecting osteoclast differentiation and function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guobin Qi, Zengxin Jiang, Wei Lu, Defang Li, Weibing Chen, Xiuying Yang, Lei Ding, Hengfeng Yuan
Summary: Berbamine, a natural product from Berberis amurensis Rupr, was found to have a protective effect against osteoporosis by inhibiting osteoclastogenesis and bone resorption without affecting osteogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Entomology
Tao Jin, Yu-Ying Lin, Qi-An Jin, Hai-Bo Wen, Zheng-Qiang Peng
JOURNAL OF ECONOMIC ENTOMOLOGY
(2016)
Article
Multidisciplinary Sciences
Hua Wen, Matthew J. McGinley, Gail Mandel, Paul Brehm
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Food Science & Technology
Xin-Zhi Wang, Ying Cheng, Na Li, Hong-Mei Wen, Rui Liu, Chen-Xiao Shan, Chuan Chai, Hao Wu
Article
Critical Care Medicine
Yanbin Gao, Wenqing Nai, Lei Yang, Zhiyang Lu, Pengwei Shi, Hui Jin, Huangding Wen, Guifang Wang
Article
Chemistry, Multidisciplinary
Yi-Long Zhu, Bo Jiang, Wen-Juan Hao, Ai-Fang Wang, Jiang-Kai Qiu, Ping Wei, De-Cai Wang, Guigen Li, Shu-Jiang Tu
CHEMICAL COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Hui-Min Wen, Bin Li, Hailong Wang, Rajamani Krishna, Banglin Chen
CHEMICAL COMMUNICATIONS
(2016)
Article
Immunology
Ping Feng, Hong Zhang, Zhuqiu Zhang, Xiaoli Dai, Ting Mao, Yinyin Fan, Xiaofang Xie, Huiyan Wen, Peijuan Yu, Yae Hu, Ruhong Yan
CLINICAL IMMUNOLOGY
(2016)
Article
Chemistry, Inorganic & Nuclear
Jing-Lin Chen, Zong-Hao Guo, Hua-Guang Yu, Li-Hua He, Sui-Jun Liu, He-Rui Wen, Jin-Yun Wang
DALTON TRANSACTIONS
(2016)
Article
Neurosciences
Jing Yang, Zhenglin Shen, Hongbin Wen, Hongbin Zhou, Chengyan Li
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Hua Sui, Li-Hong Zhou, Ya-Li Zhang, Jian-Ping Huang, Xuan Liu, Qing Ji, Xiao-Ling Fu, Hao-Tian Wen, Zhe-Sheng Chen, Wan-Li Deng, Hui-Rong Zhu, Qi Li
JOURNAL OF CELLULAR BIOCHEMISTRY
(2016)
Article
Chemistry, Organic
Ai-Fang Wang, Yi-Long Zhu, Shu-Liang Wang, Wen-Juan Hao, Guigen Li, Shu-Jiang Tu, Bo Jiang
JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Allergy
I. J. Wang, H. J. Wen, T. L. Chiang, S. J. Lin, Y. L. Guo
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2016)
Article
Oncology
Xue-Bin Zhang, Lei Song, Hong-Juan Wen, Xiao-Xue Bai, Zhen-Juan Li, Lian-Jun Ma
Article
Multidisciplinary Sciences
Jieqiong Wang, Ting Li, Bernhard A. Sabel, Zhiqiang Chen, Hongwei Wen, Jianhong Li, Xiaobin Xie, Diya Yang, Weiwei Chen, Ningli Wang, Junfang Xian, Huiguang He
SCIENTIFIC REPORTS
(2016)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)