Article
Oncology
Irina Khononov, Eyal Jacob, Ella Fremder, Nili Dahan, Michal Harel, Ziv Raviv, Boris Krastev, Yuval Shaked
Summary: ICI therapy triggers host-mediated biological processes that contribute to therapy resistance. Identification and analysis of such processes may lead to the discovery of biomarkers for clinical response and strategies for overcoming therapy resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Microbiology
Yihan Chai, Zhengze Huang, Xuqiu Shen, Tianyu Lin, Yiyin Zhang, Xu Feng, Qijiang Mao, Yuelong Liang
Summary: The microbiota in various parts of the human body, particularly in the oral cavity, gastrointestinal tract, and pancreatic tissue, plays a crucial role in the occurrence and development of cancer, such as pancreatic cancer (PC). Recent research has shown that the microbiota influences PC carcinogenesis through altered immune responses, activatin oncogenic signaling, enhancing oncogenic metabolic pathways, altering cancer cell proliferation, and triggering chronic inflammation that suppresses tumor immunity. Diagnostics and treatments based on or in combination with the microbiota offer novel insights to improve efficiency compared with existing therapies.
Article
Food Science & Technology
Mijoo Choi, Jae-Hoon Lee, Yun-Jung Lee, Hyun-Dong Paik, Eunju Park
Summary: This study investigated the immunomodulatory effects of egg yolk protein-water extract (EYW) on mice. The results showed that EYW supplementation increased B cell proliferation, regulated cytokine secretion, decreased abnormal immunoglobulin production, and improved NK cell cytotoxic activity.
Review
Neurosciences
Yiqi Liu, Jing Dong, Ziqing Zhang, Yunpeng Liu, Yang Wang
Summary: The role of Treg cells in immune modulation during ischemic stroke is crucial but still controversial. This review summarizes the temporal changes in Treg cell populations after stroke, the mechanisms of Treg cell-mediated immunomodulation in the brain, and the potential of Treg cell-based therapies. Emphasizing the importance of further research.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Food Science & Technology
Sofia Noli Truant, Daniela Maria Redolfi, Maria Belen Sarratea, Emilio Luis Malchiodi, Marisa Mariel Fernandez
Summary: Staphylococcal enterotoxins are a diverse family of bacterial exotoxins that can activate a large proportion of the host T cells. However, these toxins exhibit significant heterogeneity in their structure and homology. The mechanisms underlying their production are not fully understood. Nonetheless, studying these superantigens is crucial for understanding their functions, pathogenicity, and potential for immunotherapeutic interventions.
Review
Biochemistry & Molecular Biology
Michael Stear, Sarah Preston, David Piedrafita, Katarzyna Donskow-Lysoniewska
Summary: Nematode infection is a significant threat to human, domestic animal, and wildlife health. Resistance to infection varies among individuals, largely due to genetic variation in the immune response. Both host and nematode-derived factors play a role in regulating the immune response. However, the specific mechanisms underlying these interactions and the variation in immunomodulation among nematode species remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Kanmani Suganya, Quan Feng Liu, Byung-Soo Koo
Summary: Sandalwood leaf extract has the potential to attenuate neuroinflammation by modulating Toll-like receptors and inflammatory cytokines, thereby alleviating inflammatory effects in the nervous system.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Quentin Devalloir, Clementine Fritsch, Yara Alchammas, Francis Raoul, Vincent Driget, Caroline Amiot, Shinji Ozaki, Nico van den Brink, Renaud Scheifler
Summary: Cadmium and lead exposure enhances immune cell damage and reduces immunity, while selenium plays a crucial role in immune response. This study found that animals exposed to highly polluted environments showed higher inflammatory response to immune challenge, whereas animals with low exposure had faster recovery when fed a standard diet. Additionally, selenium played a functional role in the inflammatory response.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Geysson Javier Fernandez, Julieta M. Ramirez-Mejia, Silvio Urcuqui-Inchima
Summary: Vitamin D enhances immune response by regulating the expression of microRNAs and mRNAs in macrophage differentiation. Differentially expressed genes are associated with pathophysiological processes such as inflammatory responses and cellular stress. MiRNAs, including miR-1972, miR-1273h-5p, and miR-665, regulate genes related to the inflammatory response.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Elise C. Wilcox, Elazer R. Edelman
Summary: Endothelial cells interact with and regulate the immune system, modulating immune cell function through the expression of various molecules and influencing immune recognition outcomes. Cell-substratum interactions impact endothelial cell phenotype and subsequently affect the immune response to transplanted cells. Endothelial cells grown on different substrata exhibit distinct basal expression levels and responsiveness to inflammatory stimuli. Understanding the relationship between endothelial cell substratum and allorecognition is crucial for predicting and modifying the outcome of endothelial cell-immune interactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sean K. Wang, Constance L. Cepko
Summary: This review discusses the roles of microglia in various eye disorders and explores the potential of targeting microglia for disease treatment. Different approaches include depleting microglia, reprogramming microglia, and inhibiting their downstream effects. Future research is needed to fully utilize the therapeutic value of microglia in eye diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Jin-Can Chen, Chao Fang, Rong-Hui Zheng, Ming-Liang Chen, Duck-Hyun Kim, Young-Hwan Lee, Christyn Bailey, Ke-Jian Wang, Jae-Seong Lee, Jun Bo
Summary: This study indicates that exposure to polystyrene microplastics can induce inflammation response and impair immune functions and growth development of marine medaka larvae. Accumulation of polystyrene microplastics results in hyperactive behavior in the larvae.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Engineering, Biomedical
Jefferson O. Abaricia, Negin Farzad, Tyler J. Heath, Jamelle Simmons, Lais Morandini, Rene Olivares-Navarrete
Summary: The shift towards bioactive designs in implantable biomaterials has drawn attention to the complex interactions between cell physiologic systems and material properties, particularly physical cues. Recent research has focused on understanding the response of innate immune cells, such as neutrophils and macrophages, to implanted materials, as these cells play key roles in inflammation and ultimately dictate the outcome of implants. The review also highlights key mechanobiological findings in innate immune cells that underpin our understanding of their role in the response to implantable biomaterials.
ACTA BIOMATERIALIA
(2021)
Review
Multidisciplinary Sciences
Yangyue Cao, Xuanye Yue, Meng Jia, Jiawei Wang
Summary: Stroke is a devastating neurological disease with inflammation and oxidative stress playing major roles in post-stroke injuries. The inflammatory response is closely related to immune modulation in ischemic stroke progression. Current treatment strategies for ischemic stroke include targeting inflammation, immune modulation, and inflammatory response. Edaravone dexborneol has been approved for treating ischemic stroke in China, as it can restore redox balance and regulate inflammatory immune responses. In this review, the application of inflammatory biomarkers, neuroinflammation, and neuroimmunotherapy for ischemic stroke will be comprehensively summarized.
Review
Nutrition & Dietetics
Graciana T. Costa, Quezia D. J. S. Vasconcelos, Gislei F. Aragao
Summary: Fructooligosaccharides (FOSs) have been shown to modulate inflammatory, oxidative, and immune activity in the gut, improving human health. FOS supplementation may increase beneficial bacteria, influence metabolic disease-related factors, and promote immune response.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)