Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 27, Issue 42, Pages 7247-7270Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v27.i42.7247
Keywords
Inflammatory bowel disease; Quorum sensing; Gut microbiota; Dysbiosis; Inflammation; Intestinal barrier
Categories
Funding
- Fondation pour la Recherche Medicale [EQU202003010171]
- Association Francois Aupetit [AHLs 2019, AHLs 2021]
- Fondation pour la Recherche Medical FRM [ECO201806006843]
- CORDDIM, Ile-de-France Region
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Bacteria communicate and regulate activities through quorum sensing, impacting gut health. Various QS systems may play a crucial role in intestinal disorders. Understanding the role of bacterial social networks in gut physiology can lead to the development of new therapeutic strategies.
Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers, a process known as quorum sensing (QS). This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut microbiome. This is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal ecosystem. This review will examine the different QS systems and the evidence for their presence in the intestinal ecosystem. We will also provide clues on the role of QS molecules that may exert, directly or indirectly through their bacterial gossip, an influence on intestinal epithelial barrier function, intestinal inflammation, and intestinal carcinogenesis. This review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new player. Better understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future.
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