Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Article
Biochemistry & Molecular Biology
Keiko Maeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Eri Ishikawa, Akina Oishi, Shuji Ikegami, Naomi Kakushima, Kazuhiro Furukawa, Tadashi Iida, Yasuyuki Mizutani, Takuya Ishikawa, Eizaburo Ohno, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima
Summary: This study analyzed the usefulness of serum gelsolin as a serological biomarker for clinical and endoscopic activities in ulcerative colitis. The findings indicate that serum gelsolin level correlates with clinical and endoscopic activities in ulcerative colitis, has higher sensitivity and specificity than C-reactive protein, and can detect mucosal healing, suggesting its potential as a biomarker for ulcerative colitis.
Article
Biochemistry & Molecular Biology
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kuehl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Guenther
Summary: The paracaspase MALT1 plays a crucial role in mucosal inflammation. It is highly expressed in colonic epithelial cells of UC patients and experimental colitis. Mechanistically, MALT1 protease function inhibits ferroptosis and contributes to NF-kappa B signaling and STAT3 signaling, which are involved in inflammation and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Ursula Strandberg, Minna Hiltunen, Jari Syvaeranta, Eti E. Levi, Thomas A. Davidson, Erik Jeppesen, Michael T. Brett
Summary: Climate change and eutrophication are key stressors for shallow freshwater ecosystems and have significant impacts on phytoplankton community structure. This study found that nutrient treatment had a significant effect on phytoplankton EPA and DHA concentrations, while warming had a marginal effect. The changes in EPA and DHA concentrations were mostly related to the phytoplankton community structure and biomass.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Medicine, General & Internal
Ashish Gupta, Mohammad Alkhalil
Summary: Omega-3 polyunsaturated fatty acids (PUFAs) have been established as a therapeutic option for patients with high triglyceride levels. They have effects on lipoprotein particles and can be incorporated within the cellular membrane, leading to plaque stability and anti-inflammatory effects. However, recent clinical trials have shown inconsistent results regarding the cardioprotective effects of omega-3 fatty acids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Peiyao Wu, Siyu Yao, Xing Wang, Long Yang, Siling Wang, Wenbing Dai, Hua Zhang, Bing He, Xueqing Wang, Shujun Wang, Qiang Zhang
Summary: This study developed orally administrated IND nanoparticles (IND-NPs) for the treatment of ulcerative colitis (UC) and investigated their functions and mechanisms in cellular and animal inflammatory models. The IND-NPs were found to improve UC-associated symptoms, inhibit inflammatory response, and preserve intestinal barrier integrity through regulating intercellular junctions and restoring mitochondrial dysfunction, showing a promising potential in UC treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Gastroenterology & Hepatology
Cristian Hernandez-Rocha, Shadi Nayeri, Williams Turpin, Mike Steel, Krzysztof Borowski, Joanne M. Stempak, James Conner, Mark S. Silverberg
Summary: This study aimed to establish the prognosis, transcriptional and microbial features of histo-endoscopic remission and activity in ulcerative colitis (UC) patients. The results showed that UC patients with histo-endoscopic remission had a lower risk of relapse and their rectosigmoid mucosa transcriptional profile resembled that of healthy controls. Host genes with antimicrobial properties were significantly associated with mucosal microbiota.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Fang Chen, Yue Hu, Yi-Hong Fan, Bin Lv
Summary: This study demonstrated the clinical significance of fecal calprotectin in evaluating endoscopic patterns and clinical manifestation in ulcerative colitis patients. The cut-off value of 164 μg/g for FC concentration was found to predict clinical active disease with high sensitivity and specificity. However, further large-scale studies are needed to confirm the reliability of the cut-off value.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kazuhiko Uchiyama, Tomohisa Takagi, Katsura Mizushima, Kohei Asaeda, Mariko Kajiwara, Saori Kashiwagi, Yuki Toyokawa, Yuma Hotta, Makoto Tanaka, Ken Inoue, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Hiroaki Yasuda, Hideyuki Konishi, Mitsuo Kishimoto, Yuji Naito, Yoshito Itoh
Summary: This study aimed to investigate the relationship between mucosal cytokine expression and subsequent relapse in ulcerative colitis patients with a Mayo endoscopic subscore of 0. The results showed that several cytokines were significantly elevated in patients with subsequent relapse, with interleukin-8 expression being the most useful predictor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kana Shiraishi, Shinya Furukawa, Sen Yagi, Kenichirou Mori, Tomoyuki Ninomiya, Keitarou Kawasaki, Yuji Mizukami, Seiyuu Suzuki, Masayoshi Uraoka, Naozumi Shibata, Sanae Nakamura, Satoshi Imamine, Hidehiro Murakami, Katsuhisa Ohashi, Masamoto Torisu, Makoto Yano, Aki Hasebe, Harumi Yano, Masato Murakami, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Summary: In patients with ulcerative colitis, serum globulin showed a significant positive association with endoscopic activity and a significant inverse association with mucosal healing, especially in the low C-reactive protein group.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tomohisa Takagi, Kazuhiko Uchiyama, Mariko Kajiwara-Kubota, Saori Kashiwagi, Yuki Toyokawa, Yuma Hotta, Makoto Tanaka, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Takeshi Ishikawa, Hideyuki Konishi, Mitsuo Kishimoto, Nobuaki Yagi, Yuji Naito, Yoshito Itoh
Summary: The study investigated the efficacy of linked color imaging (LCI) in predicting the long-term prognosis of ulcerative colitis patients diagnosed with MES 0 over a 48-month period. Findings showed that LCI classification subdivided colonic mucosa diagnosed with MES 0 into two classes, with the LCI-A group having a significantly lower relapse rate than LCI-B group. This methodology can be used to evaluate mucosal healing and predict long-term outcomes in ulcerative colitis patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Hussein A. Abd Elmaksoud, Muhammed H. Motawea, Afaf A. Desoky, Mohamed G. Elharrif, Asmaa Ibrahimi
Summary: OLES-25%HYT has shown efficacy in reducing mortality rate and disease activity index (DAI), reducing oxidative stress and inflammation in colon tissue, with significant reductions in colon MDA, MPO, and NO levels and significant elevations in SOD, CAT, and GPX levels. Additionally, there was down regulation of pro-inflammatory cytokines and downregulation of the apoptotic gene Bax as well as upregulation of the anti-apoptotic gene Bcl2 compared to untreated induced ulcerative colitis group.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Micaela A. Reeves, Joshua M. Royal, David A. Morris, Jessica M. Jurkiewicz, Nobuyuki Matoba, Krystal T. Hamorsky
Summary: EPT, a recombinant variant of cholera toxin B subunit, shows promise for ulcerative colitis treatment. A solid oral formulation of EPT has been developed to prevent degradation in gastric acid, demonstrating therapeutic efficacy in mouse colitis models without the need for gastric acid neutralization pretreatment.
Article
Agricultural Engineering
Nikhil L. Kadalag, Pratik R. Pawar, Gunjan Prakash
Summary: In this study, co-cultivation of Phaeodactylum tricornutum with Aurantiochytrium limacinum was used as a unique strategy to achieve the desired fatty acid composition. The initial cell density ratio was modulated to overcome the dominance of A. limacinum and regulate the proliferation of both species, resulting in the production of polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), as well as monounsaturated fatty acids (MUFA) and pigments.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
K. Vijay Kumar Reddy, K. Akhilender Naidu
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Immunology
Vijay Kumar Reddy Kondreddy, Akhilender Naidu Kamatham
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Vijay Kumar Reddy Kondreddy, Maheswaraiah Anikisetty, Kamatham Akhilender Naidu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2016)
Article
Hematology
Vijay Kondreddy, Jue Wang, Shiva Keshava, Charles T. Esmon, L. Vijaya Mohan Rao, Usha R. Pendurthi
Article
Hematology
Vijay Kondreddy, Usha R. Pendurthi, Xiao Xu, John H. Griffin, L. Vijaya Mohan Rao
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Vijay Kondreddy, Shiva Keshava, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao
SCIENTIFIC REPORTS
(2020)
Article
Hematology
Kaushik Das, Shiva Keshava, Shabbir A. Ansari, Vijay Kondreddy, Charles T. Esmon, John H. Griffin, Usha R. Pendurthi, L. Vijaya Mohan Rao
Summary: Studies showed that FVIIa induces the release of EVs from endothelial cells through the EPCR-PAR1 signaling pathway, contributing to the hemostatic effect of FVIIa.
Article
Hematology
Vijay Kondreddy, Jhansi Magisetty, Shiva Keshava, L. Vijaya Mohan Rao, Usha R. Pendurthi
Summary: The study aims to investigate the role of Gab2 in inflammatory signaling pathways and its contribution to vascular dysfunction. The results show that silencing Gab2 can significantly attenuate the expression of TF, cell adhesion molecules, and inflammatory cytokines/chemokines induced by cytokines.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Jhansi Magisetty, Vijay Kondreddy, Shiva Keshava, Kaushik Das, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao
Summary: Recurrent spontaneous or trauma-related bleeding into joints in hemophilia leads to a debilitating joint disease called hemophilic arthropathy (HA). The treatment of HA involves preventing joint bleeding through clotting factor replacement and, in severe cases, orthopedic surgery. Recent research has shown that the administration of a specific monoclonal antibody (mAb) that blocks the activity of activated protein C (APC) offers a therapeutic potential for reducing the severity of HA without compromising its cytoprotective signaling.
Article
Hematology
Vijay Kondreddy, Shiva Keshava, Kaushik Das, Jhansi Magisetty, L. Vijaya Mohan Rao, Usha R. Pendurthi
Summary: This study reveals the important role of the Gab2-MALT1 axis in thromboinflammation. Targeting this axis may be an effective strategy to treat DVT without inducing bleeding complications.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)