Journal
VIRUS RESEARCH
Volume 304, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2021.198525
Keywords
Fish; Novirhabdoviruses; Innate immunity; IFN-I response; Immune evasion
Categories
Funding
- Natural Science Foundation [ZR2020MC081]
- Key R&D project of Shandong Province, China [2019GSF107020]
Ask authors/readers for more resources
Novirhabdoviruses, pathogenic to bony fish, interact with fish innate immunity and may exploit microRNAs for immunosuppression, interfering with host antiviral defense mechanisms.
Novirhabdoviruses belong to the Rhabdoviridae family of RNA viruses. All of the four members are pathogenic for bony fish. Particularly, Infectious hematopoietic necrosis virus (IHNV) and Viral hemorrhagic septicemia virus (VHSV) often cause mass animal deaths and huge economic losses, representing major obstacles to fish farming industry worldwide. The interactions between fish and novirhabdoviruses are becoming better understood. In this review, we will present our current knowledge of fish innate immunity, particularly type I interferon (IFN-I) response, against novirhabdoviral infection, and the evasion strategies exploited by novirhabdoviruses. Members of Tolllike receptors (TLRs) and RIG-I-like receptors (RLRs) appear to be involved in novirhabdovirus surveillance. NF kappa B activation and IFN-I induction are primarily triggered for antiviral defense. Autophagy can also be induced by viral glycoprotein (G). Although sensitive to IFN-I, novirhabdoviruses have nucleoprotein (N), matrix protein (M), and non-virion protein (NV) to interfere with host signal transduction and gene expression steps toward antiviral state establishment. Moreover, novirhabdoviruses may exploit some microRNAs for immunosuppression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available